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IMM-H007

Catalog No. T9010 CAS 1221412-23-2

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

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IMM-H007, CAS 1221412-23-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 296.00
25 mg	In stock	$ 592.00
50 mg	In stock	$ 845.00
100 mg	In stock	$ 1,170.00
1 mL * 10 mM (in DMSO)	In stock	$ 222.00

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Purity: 97.73%

Biological Description

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Description

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression

In vitro

IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration.?Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression.?Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status.?H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling.

Molecular Weight	485.45
Formula	C22H23N5O8
CAS No.	1221412-23-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (60.91 mM)

References and Literature

1. Jy C , MD Hong, Hyl F , et al. IMM-H007, a novel small molecule inhibitor for atherosclerosis, represses endothelium inflammation by regulating the activity of NF-κB and JNK/AP1 signaling[J]. Toxicology and Applied Pharmacology, 2019, 381:114732-.

Related compound libraries

This product is contained In the following compound libraries：

Nucleotide Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Epigenetics Compound Library Bioactive Compound Library NO PAINS Compound Library

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Keywords

IMM-H007 1221412-23-2 Chromatin/Epigenetic Others PI3K/Akt/mTOR signaling AMPK JNK Nuclear factor-κB WS 070117 IMM H007 AP-1 inflammatory WS070117 inhibit atherosclerosis Transforming growth factor beta receptors Activator Protein 1 cardiac fibrosis IMM-H 007 JNK/c-Jun IMMH007 IMM-H-007 NF-κB Nonalcoholic fatty liver disease NAFLD WS-070117 TGF-β Receptor AMP-activated protein kinase Nuclear factor-kappaB Inhibitor inhibitor

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