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Halofuginone hydrobromide

Catalog No. T3524 CAS 64924-67-0

Synonyms: Tempostatin, RU-19110 (hydrobromide), Stenorol

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Halofuginone hydrobromide Chemical Structure

Halofuginone hydrobromide, CAS 64924-67-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 72.00
10 mg	In stock	$ 114.00
25 mg	In stock	$ 230.00
50 mg	In stock	$ 345.00
100 mg	In stock	$ 520.00
500 mg	In stock	$ 996.00
1 mL * 10 mM (in DMSO)	In stock	$ 81.00

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Purity: 98.5%

Purity: 97.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

Prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Synonyms	Tempostatin, RU-19110 (hydrobromide), Stenorol
Molecular Weight	495.59
Formula	C16H17BrClN3O3.HBr
CAS No.	64924-67-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 49.6 mg/mL (100 mM)

References and Literature

1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4. 2. Keller TL., et al. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.

Citations

1. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of halofuginone hydrobromide, C16H18BrClN3O3Br. Powder Diffraction. 2022: 1-8. 2. Zhu J, Wei J, Lin Y, et al.Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.BMC Complementary Medicine and Therapies.2024, 24(1): 1-12.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library TGF-beta/Smad Compound Library Drug Repurposing Compound Library Antiparasitic Natural Product Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Parasitic Compound Library Natural Product Library for HTS Reprogramming Compound Library

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Keywords

Halofuginone hydrobromide 64924-67-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Metabolism Microbiology/Virology Others Stem Cells Parasite DNA/RNA Synthesis Sodium Channel TGF-beta/Smad Calcium Channel type-I RU-19110 Na channels collagen collagen-1 prolyl-tRNA Inhibitor RU19110 Halofuginone inhibit Na+ channels RU 19110 Tempostatin osteoarthritis TGF-β RU-19110 (hydrobromide) Stenorol Ca2+ channels Halofuginone Hydrobromide Ca channels Transforming growth factor beta inhibitor

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