Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.
Description | Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases. |
Targets&IC50 | prolyl-tRNA synthetase:18.3±0.5 nM(ki) |
Synonyms | Tempostatin, 卤夫酮溴氢酸盐, Stenorol, 常山酮溴酸盐, RU-19110 (hydrobromide) |
Molecular Weight | 495.6 |
Formula | C16H18Br2ClN3O3 |
CAS No. | 64924-67-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 49.6 mg/mL (100 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Halofuginone hydrobromide 64924-67-0 DNA损伤和修复 代谢 干细胞 离子通道 其他 微生物学 细胞周期 Calcium Channel DNA/RNA Synthesis Others Parasite Sodium Channel TGF-beta/Smad type-I RU-19110 Na channels collagen RU19110 collagen-1 prolyl-tRNA Inhibitor Halofuginone Tempostatin inhibit Na+ channels osteoarthritis TGF-β RU-19110 (hydrobromide) Ca2+ channels RU 19110 Ca channels Transforming growth factor beta Stenorol inhibitor