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Halofuginone hydrobromide

Catalog No. T3524 CAS 64924-67-0

Synonyms: Tempostatin, 卤夫酮溴氢酸盐, Stenorol, 常山酮溴酸盐, RU-19110 (hydrobromide)

Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. Halofuginone Hydrobromide is the hydrobromide salt of halofuginone, a semisynthetic quinazolinone alkaloid anticoccidial derived from the plant Dichroa febrifuga, with antifibrotic and potential antineoplastic activities. These effects appear to be due to halofuginone-mediated inhibition of the collagen type I and MMP-2 promoters. Collagen type I and MMP-2 play important roles in fibroproliferative diseases.

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Halofuginone hydrobromide, CAS 64924-67-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Targets&IC50

prolyl-tRNA synthetase:18.3±0.5 nM(ki)

Synonyms	Tempostatin, 卤夫酮溴氢酸盐, Stenorol, 常山酮溴酸盐, RU-19110 (hydrobromide)
Molecular Weight	495.6
Formula	C16H18Br2ClN3O3
CAS No.	64924-67-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 49.6 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhou H. et al. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase. Nature. 2013 Feb 7;494(7435):121-4. 2. Keller TL., et al. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.

Citations

1. Kaduk J A, Gates-Rector S, Blanton T N. Crystal structure of halofuginone hydrobromide, C16H18BrClN3O3Br. Powder Diffraction. 2022: 1-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library TGF-beta/Smad Compound Library Inhibitor Library DNA Damage & Repair Compound Library Wnt/Hedgehog/Notch Compound Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library

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Keywords

Halofuginone hydrobromide 64924-67-0 DNA损伤和修复代谢干细胞离子通道其他微生物学细胞周期 Calcium Channel DNA/RNA Synthesis Others Parasite Sodium Channel TGF-beta/Smad type-I RU-19110 Na channels collagen RU19110 collagen-1 prolyl-tRNA Inhibitor Halofuginone Tempostatin inhibit Na+ channels osteoarthritis TGF-β RU-19110 (hydrobromide) Ca2+ channels RU 19110 Ca channels Transforming growth factor beta Stenorol inhibitor

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