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Cat No. | Product Name | Synonyms | Targets |
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T10659 | Ca2+ channel agonist 1 | Calcium Channel , CDK | |
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction. | |||
T13047 | Synta66 | Calcium Channel | |
Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease. | |||
T16873 | SERCA2a activator 1 | Calcium Channel | |
SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart. | |||
T10885 | CRAC intermediate 2 | Others , Calcium Channel | |
CRAC intermediate 2 is a intermediate compound for CRAC inhibitor synthesis. | |||
T8674 | SR33805 | Calcium Channel | |
SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively) | |||
T24984 | 5J-4 | Calcium Channel | |
5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt. | |||
T12015 | Methyl homoveratrate | Others | |
Methyl homoveratrate, a McN5691 (RWJ-26240) metabolite detected in vivo in plasma, urine, and fecal extracts, functions as a voltage-sensitive calcium channel blocker. | |||
T7603 | Pinaverium bromide | Calcium Channel | |
Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort. | |||
T10884 | CRAC intermediate 1 | 5-(S)-Fluorowillardiine | Calcium Channel |
CRAC intermediate 1 (5-(S)-Fluorowillardiine) is a key intermediate in the chemical synthesis of a series of CRAC channel inhibitors. | |||
T3651 | YM-58483 | YM 58483,BTP2 | Calcium Channel |
YM-58483 (BTP2) is a specific and effective inhibitor of CRAC channels and subsequent Ca2+ signals. | |||
T15423 | GSK-7975A | Calcium Channel | |
GSK-7975A is a potent and orally available inhibitor of CRAC channel. | |||
T8863 | VK-II-36 | Others | |
VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor. | |||
T5457 | SN 6 | SN6 | Calcium Channel , Na+/Ca2+ Exchanger |
SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM) | |||
T2003 | ISX-9 | Isoxazole 9,Isoxazole 9 (ISX-9) | Calcium Channel , Wnt/beta-catenin |
ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer. | |||
T10690 | Cav 2.2 blocker 1 | Calcium Channel | |
Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain. | |||
T11517 | GV-58 | Calcium Channel | |
GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity. | |||
T7373 | CDN1163 | Calcium Channel | |
CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). | |||
T3543 | NS-638 | NS 638 | Calcium Channel |
NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM). | |||
T4294 | NS 11021 | NS11021 | Potassium Channel |
NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels | |||
T9031 | MCU-i4 | Others , Mitochondrial Metabolism | |
MCU-i4 is a novel negative modulator of the MCU, binding MICU1 and impairing muscle cell growth. | |||
T1198 | Tetracaine hydrochloride | Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl | Calcium Channel , Sodium Channel |
Tetracaine hydrochloride (Amethocalne HCl) (Pontocaine), a potent local anaesthetic, is a channel function allosteric inhibitor. It is primarily used as an antipruritic and topically in ophthalmology, and it has been use... | |||
T22788 | FPL64176 | FPL 64176 | Calcium Channel |
FPL64176 is a L-type calcium channels activator. | |||
T3703 | ABT-639 | ABT 639 | Calcium Channel |
ABT-639 is a potent and selective T-type calcium channel blocker. | |||
T3102 | NS-1619 | Apoptosis , Potassium Channel | |
NS1619 have cardio-protective effects after ischemia-reperfusion injury. | |||
T7216 | Mirogabalin | DS5565 | Calcium Channel |
Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects. | |||
T6777 | Bay K 8644 | (±)-BAY-K-8644,SQ 28,873 | Calcium Channel |
Bay K 8644 (SQ 28,873) is a potent, selective activator of L-type Ca2+ channel with IC50 of 17.3 nM. | |||
T5850 | Benzamil | Benzamil (hydrochloride) | Na+/Ca2+ Exchanger , Sodium Channel |
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. | |||
T0702 | Gabapentin | Neurontin,Gabapentine,Aclonium | Calcium Channel , GABA Receptor |
Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity. | |||
T8867 | RO2959 Hydrochloride | RO2959 HCl | IL Receptor , Calcium Channel , Interleukin |
RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. | |||
T5632 | Suvecaltamide | MK-8998 | Calcium Channel |
Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels. | |||
T29201 | Z944 | Z 944,Z-944 | Calcium Channel |
Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats. | |||
T11353 | Gallopamil | Methoxyverapamil | Calcium Channel |
Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy der... | |||
T2519 | Lercanidipine | Masnidipine | Calcium Channel |
Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class. | |||
T2007 | RQ-00203078 | TRP/TRPV Channel | |
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist. | |||
T6577 | Manidipine | Iperten,Franidipine,Artedil | Calcium Channel |
Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized | |||
T0327 | Fendiline hydrochloride | Fendiline HCl | Calcium Channel |
Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel. | |||
T23101 | O-3M3FBS | Others | |
Inactive analog of m-3M3FBS (PLC activator) | |||
T7127 | DC260126 | Apoptosis , GPR | |
DC260126 is a small-molecule antagonist of FFA1 (GPR40) | |||
T23280 | Ruthenium Red | Ammoniated ruthenium oxychloride | Calcium Channel |
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ... | |||
T16686 | Pyr10 | TRP/TRPV Channel | |
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels. Pyr10 inhibits... | |||
T5376 | Aranidipine | MPC1304 | Calcium Channel |
Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects. | |||
T11353L | Gallopamil hydrochloride | Methoxyverapamil hydrochloride | Calcium Channel |
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies. | |||
T17250 | W-54011 | ROS , Complement System | |
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and g... | |||
T0903 | Cinnarizine | Stugeron,Cinarizine,Dimitronal,Stutgin | Calcium Channel , Histamine Receptor |
Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS. | |||
T7683 | Adenosine amine congener | ADAC | Adenosine Receptor |
Adenosine amine congener (ADAC) (ADAC) is an agonist of selective A1 adenosine receptor,. | |||
T5023 | Propiverine hydrochloride | Others , Calcium Channel , AChR | |
Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB). | |||
T15257 | Etripamil | MSP-2017,(-)-MSP-2017 | Calcium Channel |
Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells... | |||
T16571 | Pranidipine | OPC-13340 | Calcium Channel |
Pranidipine (OPC-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker. It prolongs acetylcholine-induced relaxation in presence of endothelium as well as nitroglycerin-induced relaxation in absence ... | |||
T0163 | Nisoldipine | BAY-k 5552 | Calcium Channel , Reactive Oxygen Species |
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent. | |||
T1385 | Amlodipine | UK-48340 | Calcium Channel |
Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN2322 | Yangambin | Calcium Channel , PAFR | |
Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti... | |||
TN1121 | Evocarpine | Apoptosis , cAMP , Anti-infection , Calcium Channel , Antibacterial | |
Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels. | |||
T6S1418 | Praeruptorin C | Antioxidant , Calcium Channel | |
1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ... | |||
T4727 | Taurolithocholic acid sodium salt | Sodium taurolithocholate | Others , Calcium Channel |
Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors. | |||
T8787 | Drotaverine hydrochloride | PDE | |
Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor,and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela... | |||
T0728 | Ethosuximide | Zarontin | Calcium Channel |
Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures. | |||
T8206 | Cycleanine | Others | |
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities. | |||
T3904 | Gomisin J | Calcium Channel , AMPK | |
Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK... | |||
T5723 | Menthol | DL-Menthol | Others , Calcium Channel |
Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. | |||
T5S2059 | Glaucine | Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE | |
Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h... | |||
T15027 | Cyclopiazonic acid | Calcium Channel | |
Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce... | |||
T4S1422 | Praeruptorin E | Others , Calcium Channel | |
1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit... | |||
TQ0302 | Thapsigargin | Apoptosis , SARS-CoV , Calcium Channel | |
Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ... | |||
T3013 | Catharanthine tartrate | Catharanthine hemitartrate | Others , Calcium Channel |
Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities. | |||
TN1008 | Psoralenoside | CaMK , Calcium Channel , Histamine Receptor | |
Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. | |||
T6S1500 | Ginsenoside Rf | Ginsenoside-Rf,Panaxoside Rf | Calcium Channel , Endogenous Metabolite |
Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel. | |||
T2782 | Catharanthine | (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine | Calcium Channel , AChR |
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). | |||
T10024 | 1-Octanol | Octanol | Calcium Channel , Endogenous Metabolite |
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ... | |||
T2946 | Tanshinone IIA sulfonate sodium | Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium | CaMK , P450 , Calcium Channel |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... | |||
TN7108 | Urolithin C | Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite | |
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. | |||
T4S1419 | (±)-Praeruptorin A | Praeruptorin A,(-)-Praeruptorin A | p38 MAPK , Calcium Channel , Akt |
1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ... | |||
T3S1916 | Heteroclitin D | Calcium Channel | |
1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor. | |||
T5701 | OPHIOPOGONIN D | RAAS , Calcium Channel , NF-κB , PPAR | |
Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation. | |||
T23107 | Ononetin | 2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone | TRP/TRPV Channel |
Ononetin (2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone) is a TRPM3 channel blocker(IC50: 0.3 μM). | |||
T1221 | Acetylcholine chloride | ACh chloride,Pilofrin | Calcium Channel , Endogenous Metabolite , AChR |
Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen... | |||
T6368 | Abscisic Acid | Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin) | Others , Proton pump , Endogenous Metabolite |
Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth. | |||
T8288 | 14-Deoxyandrographolide | Apoptosis , Others | |
14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release. | |||
T4590 | (+)-Kavain | Kavain,L-KAWAIN,(R)-KAWAIN | Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter |
(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B. | |||
T11665 | Ionomycin calcium | SQ23377 calcium | Apoptosis , Calcium Channel , Antibacterial , Antibiotic , PKC |
lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly spec... | |||
T3915 | Ginsenoside Ro | Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V | Calcium Channel , Reductase , Prostaglandin Receptor |
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. | |||
T2996 | Tetrandrine | NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A | Potassium Channel , Calcium Channel |
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c... | |||
T2878 | Ginsenoside Rd | Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII | P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite |
Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors. | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T3377 | L-Phenylalanine | (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine | Calcium Channel , Endogenous Metabolite , iGluR |
L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels. | |||
T0928 | L-Ascorbic acid | Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate | Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite |
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-... | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T6674 | L-Ascorbic acid sodium salt | (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate | Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite |
L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement. | |||
T7285 | Ionomycin | Calcium Channel | |
Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as ... | |||
TN1065 | Hirsutine | Apoptosis | |
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation acti... | |||
T19882 | Bryonolic acid | UNII-J7YR6A878I,20-epi-Bryonolic acid | Apoptosis , Antioxidant , Calcium Channel |
Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apo... | |||
T5120 | Rhamnose | 6-Deoxyhexopyranose,6-Deoxy-L-mannose,alpha-L-Rhamnose | Calcium Channel , Endogenous Metabolite |
Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose-dependent stimulation of the calcium-signaling pathway, ind... | |||
T2944 | Danshensu sodium salt | Sodium Danshensu,(±)-DanShenSu sodium salt,(±)-DanShenSu sodium sal | P450 , Autophagy |
Danshensu sodium salt (Sodium Danshensu) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium. | |||
T2782L | Catharanthine Tartrate(2468-21-5(free base)) | Calcium Channel | |
Catharanthine Tartrate is a natural product isolated from Madagascar periwinkle, Catharanthine Tartrate inhibits voltage-operated L-type Ca2+ channel, with anti-cancer and blood pressure-lowering activity | |||
TN1136 | Procyanidin A1 | Proanthocyanidin A1 | LDL , Calcium Channel , PKC |
Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. | |||
T37705 | 1,2,4-Trihydroxybenzene | Benzene-1,2,4-triol | Calcium Channel |
1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) is a by-product of coffee bean roasting and is found in mouse, arabica coffee.1,2,4-Trihydroxybenzene is a benzotriol that increases Ca2+ concentration in rat thymic lymphocy... | |||
TN1721 | Gypenoside L | ERK , p38 MAPK , Calcium Channel , NF-κB , ROS | |
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also inhibit non-small cell lung carcinoma A549 cell inhibitory a... | |||
T5238 | 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine | 1,2-Dipalmitoyl-sn-glycero-3-PE,1,2-Dipalmitoyl-sn-glycerol-3-Phosphoethanolamine,1,2-DPPE | Others , Endogenous Metabolite |
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE), a phospholipid member of the glycerophosphonoethanolamine family, is a major component in biological membranes. Studies focused on interactions between DPPE and ch... | |||
T1407 | (-)-Menthol | L-Menthol,Levomenthol,Menthomenthol,Menthacamphor | Opioid Receptor , Endogenous Metabolite , TRP/TRPV Channel |
(-)-Menthol (Levomenthol) is a levo isomer of menthol, an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties. When added to pharmaceuticals and foo... | |||
T5S0527 | Rhodojaponin III | Others | |
1. Rhodojaponin III has antifeedant and oviposition deterrence effects against many kinds of insects, BdorCSP2 of B. dorsalis could be involved in chemoreception of Rhodojaponin III and played a critical role. 2. Rhodoja... | |||
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Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-03259 | Carbonic Anhydrase 2 Protein, Rat, Recombinant (His) | Rat | E. coli |
Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide abso... | |||
TMPY-02111 | Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Carbonic Anhydrase 2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 30.4 kDa and the accession number is AAH55291.1. | |||
TMPH-01906 | SMARCA2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
SMARCA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-01868 | FUCA2 Protein, Human, Recombinant (GST) | Human | E. coli |
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. FUCA2 Protein, Human, Recombinant (GST) is expre... | |||
TMPH-01424 | GUCA2B Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and el... | |||
TMPH-01905 | SMARCA2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPY-06353 | GUCA2B Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
GUCA2B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 48.55 kDa and the accession number is Q3UWA6-1. | |||
TMPY-02245 | SNAP-25 Protein, Human, Recombinant (His) | Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains... | |||
TMPY-01964 | CD16a Protein, Human, Recombinant (F176V, His) | Human | HEK293 Cells |
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also ... | |||
TMPY-01101 | Coagulation factor X/F10 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the... | |||
TMPK-01241 | CARHSP1 Protein, Human, Recombinant | Human | E. coli |
Ca2+-regulated heat-stable protein of 24 kDa (CRHSP-24) is a serine phosphoprotein originally identified as a physiological substrate for the Ca2+-calmodulin regulated protein phosphatase calcineurin (PP2B). CRHSP-24 is ... | |||
TMPY-01605 | STIM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human ... | |||
TMPY-04373 | CAMKII alpha/CAMK2A Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Ca2+/calmodulin-dependent protein kinase2A (CAMK2A) belongs to the serine/threonine protein kinase family and, together with other 28 different isoforms, belongs to the Ca2+/ calmodulin-dependent protein kinase subfamily... | |||
TMPK-01259 | S100A9 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | E. coli |
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2 binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stabili... | |||
TMPK-01324 | S100A9 Protein, Canine, Recombinant (His) | Canine | E. coli |
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2 binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stabili... | |||
TMPJ-00029 | CALM1 Protein, Human, Recombinant | Human | E. coli |
Calmodulin (CaM) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required f... | |||
TMPH-02541 | Beta Defensin 1/DEFB1 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization i... | |||
TMPH-03101 | DEFB1 Protein, Pig, Recombinant (GST) | Sus scrofa (Pig) | E. coli |
Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization i... | |||
TMPK-00327 | CD19 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells |
CD19 is a 95 kDa transmembrane glycoprotein that plays a central role in B cell activation and humoral immune responses.Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases th... | |||
TMPY-03863 | CAPG Protein, Human, Recombinant | Human | E. coli |
CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ ... | |||
TMPJ-01229 | SUMF1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Human Sulfatase Modifying Factor 1 (SUMF1) is a 42kDa protein. SUMF1 is a Ca2+-binging member of the sulfatase-modifying factor family. SUMF1 is a soluble ER lumenal glycoprotein, it converts inactive sulfatases into an ... | |||
TMPY-04327 | VEGFB Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positive... | |||
TMPJ-00944 | PPP1CC Protein, Human, Recombinant (His) | Human | E. coli |
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractil... | |||
TMPJ-01372 | Cornulin Protein, Human, Recombinant (His) | Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-ter... | |||
TMPJ-01261 | PPP1R14A Protein, Human, Recombinant (His) | Human | E. coli |
Protein Phosphatase 1 Regulatory Subunit 14A (PPP1R14A) belongs to the PP1 inhibitor family. PPP1R14A is mapped to chromosome 19q13.13-q13.2. PPP1R14A binds directly to protein kinase C and casein kinase I. Meantime, PPP... | |||
TMPJ-01044 | NCALD Protein, Human, Recombinant (His) | Human | E. coli |
Neurocalcin-delta (NCALD) is a neuronal calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. It expressed in mammalian brains. NCALD contains an N-terminal myristoylation signal and four EF-h... | |||
TMPJ-01113 | RCN2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Reticulocalbin-2 (RCN2, also named as ERC-55), is a 55-kDa Ca2+-binding protein containing six EF-hands, which was identified to be localized in endoplasmic reticulum. RCN2 is belonging to Reticulocalbin (RCN) family, th... | |||
TMPJ-00682 | CD39L1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
CD39L1 protein (ENTPD2 or NTPDase2) is a member of the ecto-nucleoside triphosphate diphosphohydrolase family which the main role is termination of purinergic signaling. CD39L1 gene encodes a precursor protein with 495 a... | |||
TMPY-00517 | LSP1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LSP1 (Lymphocyte Specific Protein 1) is a Protein Coding gene. This gene encodes an intracellular F-actin binding protein. The protein is expressed in lymphocytes, neutrophils, macrophages, and endothelium and may regula... | |||
TMPY-02592 | Annexin VI/ANXA6 Protein, Human, Recombinant (His) | Human | E. coli |
Annexin A6, also known as ANXA6 or ANXAⅥ, belongs to a family of Ca2+-dependent membrane and phospholipid binding proteins. Members of this family have been implicated in membrane-related events along exocytotic and endo... | |||
TMPJ-00382 | P-selectin Protein, Mouse, Recombinant (Avi & His), Biotinylated | Mouse | HEK293 Cells |
P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothel... | |||
TMPY-02129 | Transglutaminase 3/TGM3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Transglutaminases (TGase) are a family of calcium-dependent acyl-transfer enzymes ubiquitously expressed in mammalian cells and responsible for catalyzing covalent cross-links between proteins or peptides. Transglutamina... | |||
TMPY-02640 | FAM3B Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and b... | |||
TMPY-02760 | CALML3 Protein, Human, Recombinant (His) | Human | E. coli |
Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates. Calmodulin-like protein 3 (CALML3) is a ... | |||
TMPY-04423 | CAMKI gamma/CAMK1G Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells |
Calmodulin-Dependent Protein Kinase (CaM Kinase) is a kind of protein phosphorylate multiple downstream targets. Concentration of cytosolic calcium functions as a second messenger that mediates a wide range of cellular r... | |||
TMPY-02191 | BLNK Protein, Human, Recombinant (His) | Human | HEK293 Cells |
B-cell linker protein, also known as B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte p... | |||
TMPH-02282 | Ubiquilin-1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa... |
Cat No. | Product Name | ||
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L5300 | Mitochondria-Targeted Compound Library | 812 compounds | |
A unique collection of 812 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine; |