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L-Ascorbic acid sodium salt

Catalog No. T6674 CAS 134-03-2

Synonyms: (+)-Sodium L-ascorbate, Vitamin C sodium salt, Sodium ascorbate, L-Ascorbic acid sodium, Sodium L-ascorbate

L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.

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L-Ascorbic acid sodium salt Chemical Structure

L-Ascorbic acid sodium salt, CAS 134-03-2

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500 mg	In stock	$ 42.00
1 g	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

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Description	L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
In vitro	Sodium ascorbate has a growth inhibiting action only at high concentrations in cultured human neoplastic cell lines MCF-7 (breast carcinoma), KB (oral epidermoid carcinoma), and AN3-CA (endometrial adenocarcinoma). Sodium ascorbate combined with vitamin K3 demonstrates a synergistic inhibition of cell growth at 10 to 50 times lower concentrations in cultured human neoplastic cell lines MCF-7, KB, and AN3-CA, at this level separately given vitamins are not toxic. This tumor cell growth inhibitory effect is completely suppressed by the addition of catalase to the culture medium containing vitamins C and K3, suggesting an excessive production of hydrogen peroxide as being implied in mechanisms responsible for the above-mentioned effects. [1] Sodium ascorbate combined with vitamin K3 results in a synergistic effect on growth inhibition in cultured human endometrial adenocarcinoma (AN3CA) cells. [2] Sodium ascorbate results in a rapid increase in the intracellular concentration of Ca2+ ions and subsequent apoptotic cell death in HL-60 cells, characterized by cell shrinkage, nuclear fragmentation and cleavage of internucleosomal DNA to yield fragments that are multiples of 180-200 base pairs, are induced. [3] Sodium ascorbate (100 μM) induces DNA single-strand breaks in human cells, Fibroblasts and Molt-4 cells are significantly more sensitive than lymphocytes. Sodium ascorbate (50 μM) results in significant cell loss in Molt-4 cells, but not in lymphocyte and fibroblast cultures. [4]
In vivo	Tg rats treated with sodium?L-ascorbate show a higher incidence of carcinoma (29.6%), compared to those without sodium?L-ascorbate (15.4%). Independent of the sodium?L-ascorbate treatment, transgenic rats exhibit various kinds of malignant tumors in various organs[5]. After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the sodium?L-ascorbate-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the sodium?L-ascorbate-treatment is evident only with simple hyperplasias and PN hyperplasias in rats[6].
Source	Natural Products > Rhamnaceae > Ziziphus

Synonyms	(+)-Sodium L-ascorbate, Vitamin C sodium salt, Sodium ascorbate, L-Ascorbic acid sodium, Sodium L-ascorbate
Molecular Weight	199.11
Formula	C6H8NaO6
CAS No.	134-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.25 mg/mL (31.39 mM), Sonication is recommended.

H2O: 198.9 mM

References and Literature

1. Noto V, et al. Cancer, 1989, 63(5), 901-906. 2. De Loecker W, et al. Anticancer Res, 1993, 13(1), 103-106. 3. Sakagami H, et al. Life Sci, 1996, 58(14), 1131-1138. 4. Singh NP, et al. Mutat Res, 1997, 375(2), 195-203. 5. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Traditional Chinese Medicine Monomer Library Neuronal Signaling Compound Library Metabolism Compound Library Anti-Fibrosis Compound Library NO PAINS Compound Library

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Keywords

L-Ascorbic acid sodium salt 134-03-2 Apoptosis Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Others Calcium Channel Reactive Oxygen Species Endogenous Metabolite Ca channels Vitamin C (+)-Sodium L-ascorbate Vitamin C sodium salt L Ascorbic acid sodium salt Sodium ascorbate L-Ascorbic acid sodium inhibit Inhibitor Ca2+ channels L-Ascorbic acid LAscorbic acid sodium salt Vitamin C sodium Sodium L-ascorbate inhibitor

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