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Cinnarizine

Catalog No. T0903 CAS 298-57-7

Synonyms: Stugeron, Cinarizine, Dimitronal, Stutgin

Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.

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Cinnarizine, CAS 298-57-7

Pack Size	Availability	Price/USD
50 mg	In stock	$ 39.00
100 mg	In stock	$ 51.00
200 mg	In stock	$ 79.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 100%

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Description	Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.
In vitro	Cinnarizine inhibits melanogenesis in B16 cells by a dose-dependent manner at the non-cytotoxic concentrations and is a histamine receptor antagonists[3].
In vivo	Cinnarizine has anticonvulsive properties in rats and mice. It could provide a direct neuroprotective effect against the damaging influx of calcium and also prevent neuronal damage as a result of MES- and PTZ-induced seizures[2]. Cinnarizine induces behavioural changes such as alopecia, bucolingual dyskinesia and reduction of motor activity in female parkin knock out (PK-KO) mice but not in wild-type (WT) controls.PK-KO mice have high striatal dopamine levels and increased dopamine metabolism in spite of low reduced tyrosine hydroxylase protein. Cinnarizine, which blocks dopamine receptors and increases dopamine release, further increased dopamine metabolism[3]. Its half-life is 4 hours.
Cell Research	MTT assay is performed to examine the viability of cells. Afterwards, the cells are incubated with the samples for 48 h, the culture medium is removed and replaced with 1 mg/mL MTT solution dissolved in phosphate-buffered saline (PBS) and incubated for an additional 2 h. The MTT solution is then removed and DMSO was added, following which the absorbance of the dissolved formazan crystals is determined at 570 nm by a spectrophotometer.(Only for Reference)

Synonyms	Stugeron, Cinarizine, Dimitronal, Stutgin
Molecular Weight	368.51
Formula	C26H28N2
CAS No.	298-57-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 68 mg/mL (184.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Krzysztof Sendrowski, et al. Pharmacological Reports. 2013, 65(3):730-736. 2. Brahmane RI, et al. J Pharmacol Pharmacother. 2010, 1(2):78-81. 3. Serrano A, et al. Neuropharmacology. 2005, 49(2):208-19.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library FDA-Approved & Pharmacopeia Drug Library Histamine & Melatonin Receptor-Targeted Compound Library ReFRAME Related Library Bioactive Compound Library

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DS16570511 Aranidipine Marmin Flunarizine dihydrochloride Manidipine dihydrochloride Alismol Gypenoside L Efonidipine

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Keywords

Cinnarizine 298-57-7 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel Histamine Receptor Inhibitor inhibit Ca channels Stugeron Ca2+ channels Cinarizine Dimitronal Stutgin inhibitor

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