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Bryonolic acid

Catalog No. T19882 CAS 24480-45-3

Synonyms: UNII-J7YR6A878I, 20-epi-Bryonolic acid

Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.

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Bryonolic acid, CAS 24480-45-3

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5 mg	Inquiry	$ 769.00

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Purity: 99.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apoptosis by inhibiting Ca2+ in-flux and modulating gene expression in the Ca2+-CaMKII-CREB signalling pathway.
Targets&IC50	M1 mAChR:7.08 (pKi), M3 mAChR:6.70 (pKi), mAChR4:7.00 (pKi), H1 Receptor:7.48 (pA2), M2 mAChR:7.78 (pKi)
In vitro	In the presence of three elicitors (methyl jasmonate, yeast extract, and chitosan), cell suspensions treated with 1 mg/mL of chitosan for eight days led to higher bryonolic acid contents (23.56 ± 1.68 mg/g dry weight),cell culture and root extracts with high bryonolic acid contents resulted in significantly higher percent cell viabilities than those observed under control (1% v/v DMSO) treatment in Saos-2 and MCF-7 cells[1]. Bryonolic acid inhibits ACAT in intact cancer cells with an IC50 of 12.6 ± 2.4 µM.Bryonolic acid inhibited both clonogenicity and invasiveness of several cancer cell lines[2].
In vivo	Treatment with 500 mg/kg Bryonolic acid or vehicle by intraperitoneal injection in Nrf2 wild-type or Nrf2 knockout mice revealed that Bryonolic acid effectively induced HO-1 in a manner dependent on the Nrf2-Keap1 pathway[3].

Synonyms	UNII-J7YR6A878I, 20-epi-Bryonolic acid
Molecular Weight	456.7
Formula	C30H48O3
CAS No.	24480-45-3

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1 mg/mL (2.19 mM), Sonication is recommended.

References and Literature

1. Pornpatsorn Lertphadungkit, et al. Enhanced Production of Bryonolic Acid in Trichosanthes cucumerina L. (Thai Cultivar) Cell Cultures by Elicitors and Their Biological Activities. Plants (Basel). 2020 Jun 2;9(6):709. 2. Farid Khallouki, et al. Bryonolic Acid Blocks Cancer Cell Clonogenicity and Invasiveness through the Inhibition of Fatty Acid: Cholesteryl Ester Formation. Biomedicines. 2018 Feb 12;6(1):21. 3. Tonibelle N Gatbonton-Schwager , et al. Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo. J Nat Prod. 2012 Apr 27;75(4):591-8. 4. Barker EC, Gatbonton-Schwager TN, Han Y, Clay JE, Letterio JJ, Tochtrop GP. Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages. J Nat Prod. 2010 Jun 25;73(6):1064-8. doi: 10.1021/np1000076. PubMed PMID: 20481554; PubMed Central PMCID: PMC2905313.

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Keywords

Bryonolic acid 24480-45-3 Apoptosis Membrane transporter/Ion channel Metabolism oxidation-reduction Calcium Channel Antioxidant UNII-J7YR6A878I 20-epi-Bryonolic acid inhibitor inhibit

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