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PI3K/Akt/mTOR signaling AMPK Gomisin J

Gomisin J

Catalog No. T3904   CAS 66280-25-9

Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.

Gomisin J, CAS 66280-25-9
Pack Size Availability Price/USD Quantity
1 mg In stock 50.00
5 mg In stock 140.00
10 mg In stock 230.00
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Purity 99.59%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK, LKB1 and Ca2+/calmodulin-dependent protein kinase II and inhibition of fetuin-A in HepG2 cells.
Targets&IC50 AMPK ,   Calcium Channel
Molecular Weight 388.46
Formula C22H28O6
CAS No. 66280-25-9

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kim M, et al. Gomisin J Inhibits Oleic Acid-Induced Hepatic Lipogenesis by Activation of the AMPK-Dependent Pathway and Inhibition of the Hepatokine Fetuin-A in HepG2 Cells. J Agric Food Chem. 2015 Nov 11;63(44):9729-39. 2. Ye BH, et al. Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability. Hypertens Res. 2015 Mar;38(3):169-77.

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