Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 48.00 | |
10 mg | In stock | $ 80.00 | |
25 mg | In stock | $ 146.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 372.00 | |
200 mg | In stock | $ 549.00 | |
500 mg | In stock | $ 869.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 54.00 |
Description | Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway. |
In vitro | Urolithin C is a glucose-dependent activator of insulin secretion acting by facilitating L-type Ca2+ channel opening and Ca2+ influx into pancreatic β-cells.Urolithin C enhanced glucose-induced extracellular signal-regulated kinases 1/2 (ERK1/2) activation as shown by higher phosphorylation levels in INS-1 β-cells[2]. Urolithin C stimulates reactive oxygen species (ROS) formation[2]. |
In vivo | In male Wistar rat, the half-life of the terminal part is 11.3 h and the total clearance (CL/F) is 3.41 L/h/kg. The initial volume of distribution (V1/F) is 0.831 L/kg and the steady-state volume of distribution (Vss/F) is 55.6 L/kg after the intraperitoneal administration of Urolithin C (10 mg/kg)[3]. |
Molecular Weight | 244.2 |
Formula | C13H8O5 |
CAS No. | 165393-06-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (204.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Urolithin C 165393-06-6 Apoptosis Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Tyrosine Kinase/Adaptors IGF-1R Endogenous Metabolite Calcium Channel Reactive Oxygen Species insulin Ca channels Polyphenols ROS mitochondria anti-diabetic gut-microbial Inhibitor glucose-dependent metabolite β-cells ERK1/2 Ca2+ channels inhibit inhibitor