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SERCA2a activator 1

Catalog No. T16873 CAS 2139330-34-8

SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.

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SERCA2a activator 1, CAS 2139330-34-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 297.00
5 mg	In stock	$ 647.00
10 mg	In stock	$ 987.00
25 mg	In stock	$ 1,470.00
50 mg	In stock	$ 1,990.00
100 mg	In stock	$ 2,680.00
1 mL * 10 mM (in DMSO)	In stock	$ 828.00

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Purity: 99.52%

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Description	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.
In vitro	SERCA2a activator 1 activates the Ca2+-dependent ATPase activity of cardiac sarcoplasmic reticulum vesicles but not that of skeletal muscle SR vesicles that lack phospholamban. SERCA2a activator 1 also increases the Ca2+ transients and contraction and relaxation of isolated adult rat cardiomyocytes. The surface plasmon resonance assay reveals a direct interaction between SERCA2a activator 1 and PLN, suggesting that the binding of SERCA2a activator 1 to PLN attenuates its inhibition of SERCA2a, resulting in SERCA2a activation [1].
In vivo	SERCA2a activator 1 (30mg/kg; intravenous injection; male Wistar rats) treatment obviously increases the diastolic function in anesthetized normal rats [1].

Molecular Weight	551.66
Formula	C32H29N3O4S
CAS No.	2139330-34-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (108.76 mM), Sonication and heating to 80℃ are recommended.

References and Literature

1. Kaneko M, et al. A pyridone derivative activates SERCA2a by attenuating the inhibitory effect of phospholamban. Eur J Pharmacol. 2017 Nov 5;814:1-8.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Bioactive Compounds Library Max Metabolism Compound Library Anti-Cancer Compound Library Mitochondria-Targeted Compound Library

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Keywords

SERCA2a activator 1 2139330-34-8 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels phospholamban Inhibitor Ca2+ channels SERCA2a SERCA-2a activator 1 failure reticulum Ca2+ sarcoplasmic diastolic heart systolic inhibit inhibitor

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