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RO2959 Hydrochloride

Catalog No. T8867 CAS 1219927-22-6

Synonyms: RO2959 HCl

RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.

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RO2959 Hydrochloride, CAS 1219927-22-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 135.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 428.00
25 mg	In stock	$ 686.00
50 mg	In stock	$ 969.00
100 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 329.00

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Purity: 97.42%

Biological Description

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Storage & Solubility Information

Description	RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
Targets&IC50	CRAC channel:402 nM
In vitro	RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction).

Synonyms	RO2959 HCl
Molecular Weight	463.93
Formula	C21H20ClF2N5OS
CAS No.	1219927-22-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL (21.55 mM)

References and Literature

1. Chen G, Panicker S, Lau KY, Apparsundaram S, Patel VA, Chen SL, Soto R, Jung JK, Ravindran P, Okuhara D, Bohnert G, Che Q, Rao PE, Allard JD, Badi L, Bitter HM, Nunn PA, Narula SK, DeMartino JA. Characterization of a novel CRAC inhibitor that potently blocks human T cell activation and effector functions. Mol Immunol. 2013 Jul;54(3-4):355-67.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Neuronal Signaling Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library Bioactive Compound Library Anti-Hypertension Compound Library Cytokine Inhibitor Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RO2959 Hydrochloride 1219927-22-6 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Calcium Channel IL Receptor Interleukin RO-2959 Hydrochloride IP3 SOCE RO 2959 Hydrochloride Ca2+ release-activated Ca2+ channels Interleukin Related inhibit IL-2 Stim1 CRAC Channel anti-proliferation RO 2959 Calcium release-activated channels T-cell RO-2959 Orai1 heart RO2959 Inhibitor failure RO2959 HCl inhibitor

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