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Ca2+ channel agonist 1

Catalog No. T10659   CAS 1402821-24-2

Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.

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Ca2+ channel agonist 1 Chemical Structure
Ca2+ channel agonist 1, CAS 1402821-24-2
Pack Size Availability Price/USD Quantity
1 mg In stock $ 163.00
5 mg In stock $ 347.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
100 mg In stock $ 1,520.00
500 mg In stock $ 2,970.00
1 mL * 10 mM (in DMSO) In stock $ 382.00
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Purity: 98.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.
Targets&IC50 N-type Ca2+ channel:14.23 μM (EC50), CDK2:3.34 μM (EC50)
In vitro Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
Molecular Weight 354.45
Formula C19H26N6O
CAS No. 1402821-24-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (112.85 mM), sonification is recommended.

TargetMolReferences and Literature

1. Liang M, et al. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. ACS Med Chem Lett. 2012 Oct 1;3(12):985-990.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library Ion Channel Inhibitor Library Calcium Channel Compound Library Anti-Hypertension Compound Library Metabolism Compound Library Reprogramming Compound Library Anti-Cardiovascular Disease Compound Library Neuronal Signaling Compound Library

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Keywords

Ca2+ channel agonist 1 1402821-24-2 Cell Cycle/Checkpoint Membrane transporter/Ion channel Metabolism Calcium Channel CDK Ca2+ channels Inhibitor inhibit Ca channels Cyclin dependent kinase Ca-2+ channel agonist 1 inhibitor

 

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