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NS 11021

Catalog No. T4294 CAS 956014-19-0

Synonyms: NS11021

NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels

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NS 11021, CAS 956014-19-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
2 mg	In stock	$ 122.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 328.00
25 mg	In stock	$ 553.00
50 mg	In stock	$ 789.00
100 mg	In stock	$ 1,070.00
1 mL * 10 mM (in DMSO)	In stock	$ 229.00

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Purity: 97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

NS 11021 (NS11021) , a novel opener of large-conductance Ca(2+)-activated K(+) channels

In vivo

NS11021 increased currents sensitive to the selective BK(Ca) channel blocker, iberiotoxin (IbTX) in SMCs, but did not modulate K(+) current in HUVECs.?NS11021 reduced [Ca(2+)](i) and tension in penile arteries.?IbTX inhibited the vasorelaxation induced by NS11021 and sildenafil in human erectile tissue.?NS11021 and sildenafil but not vehicle increased erectile responses in anaesthetized rats, an effect which was abolished after pretreatment with tetraethylammonium[1].

Synonyms	NS11021
Molecular Weight	511.24
Formula	C16H9BrF6N6S
CAS No.	956014-19-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (489.01 mM), Sonication is recommended.

References and Literature

1. Kun A , Matchkov V V , Stankevicius E , et al. NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats[J]. British Journal of Pharmacology, 2010, 158(6):1465-1476. 2. Bentzen BH, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Potassium Channel Blocker Library Bioactive Compound Library Anti-Cancer Compound Library ReFRAME Related Library NO PAINS Compound Library Ion Channel Inhibitor Library

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Keywords

NS 11021 956014-19-0 Membrane transporter/Ion channel Potassium Channel NS11021 Inhibitor inhibit Ca2+ channel KCa1.1 KcsA NS-11021 inhibitor

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