Mitochondria-Targeted Compound Library

Catalog No. L5300

Library Compound List Excel SDF

The mitochondrion is a double-membrane-bound discrete organelle found in most eukaryotic organisms, generating most of the cell's supply of adenosine triphosphate (ATP) and controlling the cellular basal metabolic rate, called as the cell's powerhouses. In addition to supplying cellular energy, mitochondria are the major source of ROS (reactive oxygen species) that reflect the level of cellular oxidative stress and play an important role in mitochondria ROS signaling such as apoptosis, proliferation, and aging, etc. In addition, the fine modulation of mitochondrial calcium (Ca2+) homeostasis plays a fundamental role in many of the processes involving this organelle. Mitochondrial Ca2+ accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. Mitochondrial DNA mutations may lead to many mitochondrial metabolic disorders, and are thought to contribute to aging by promoting apoptosis. Mitochondria therefore represent an attractive drug target for metabolic diseases, neurodegeneration, or hyperproliferative diseases (cancer). A number of pre-clinical and clinical data have shown that mitochondria as drug targets have great potential. Small molecule drugs or biologics can act on mitochondria through various pathways including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca2+ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

Mitochondria-Targeted Compound Library from TargetMol, a unique collection of 830 compounds targeting mitochondria, can be used for research in mitochondrial medicine and related target study.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Pack Size
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

Request for Quote

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at inquiry@targetmol.com

Request Library

Product Description

A unique collection of 830 promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for research in mitochondrial medicine;
Targets include mitochondria related targets, such as ATPase, mitochondria-associated hexokinase, Bcl-2, NADP, etc. and inhibitors for the autophagy initiating factor, ULK1, also include other promising mitochondria-targeted compounds such as lonidamine, paclitaxel, etc;
Bioactivity and safety confirmed by pre-clinical research and clinical trials;
Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
Structurally diverse, medicinally active, and cell permeable;
NMR and HPLC validated to ensure high purity and quality;

Library Customization

Targetmol Compound Libraries can be highly customized! Learn More

Packaging And Storage

Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
Shipped with blue ice

Supporting Files

Library Handling Instructions (635 KB) Targetmol Library Catalog (13.2 MB) Request for Library Compostion in Excel and SDF files

Publications Cited TargetMol Libraries

1. Cell Metabolism. 2024, 36(1): 176-192. e10. 2. The Journal of Clinical Investigation. 2023. 3. Advanced Science. 2023: 2303183. 4. Cell Stem Cell. 2022 Apr 29(4) 545–558. 5. Science Bulletin. 2022. 6. Science Translational Medicine. 2022, 14(656): eabn3231. 7. Science Advances. 2023, 9(9): eade3760. 8. Nature. 2020, 582: 289-293. 9. Nature Biotechnology. 2021, 39(11): 1444-1452.

10. Nature Communications. 2022, 13(1): 1-15.. 11. Nature Communications. 2023, 14(1): 1020.. 12. Nature Communications. 2023, 14(1): 2756.. 13. Blood. 2021, 137(11): 1478-1490. 14. Nucleic Acids Research. 2021. 15. Nature Communications. 2023, 14(1): 7574. 16. Advanced Science. 2020, 7(16): 2000925. 17. Angewandte Chemie. 2021. 18. Acta Pharmaceutica Sinica B. 2022. 19. Protein & Cell. 2021, 12(11): 877-888. 20. Bone Research. 2023, 11(1): 54. 21. Pharmacology & Therapeutics. (2021): 107930. 22. Nature Communications. 2021, 12(1): 1-12. 23. Journal of Cell Biology. 2022, 221(5): e202112024.

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Library Composition

Reactive Oxygen Species (169)

Apoptosis (141)

Autophagy (130)

COX (124)

Endogenous Metabolite (69)

MAO (61)

BCL (61)

ATPase (60)

Mitochondrial Metabolism (57)

Mitophagy (55)

ROS (54)

Dehydrogenase (48)

Antibacterial (47)

PPAR (42)

Monoamine Oxidase (42)

NADPH (26)

Ferroptosis (23)

Parasite (23)

Antifungal (23)

Antibiotic (22)

Proton pump (18)

Antioxidant (17)

NF-κB (17)

HIV Protease (17)

Influenza Virus (15)

Potassium Channel (14)

Caspase (14)

P450 (14)

Calcium Channel (13)

DNA/RNA Synthesis (13)

NO Synthase (12)

ROS Kinase (11)

PDK (11)

p38 MAPK (10)

Topoisomerase (10)

NADPH-oxidase (10)

AMPK (9)

Virus Protease (8)

PARP (8)

HIF/HIF Prolyl-Hydroxylase (8)

Sodium Channel (8)

p53 (7)

HSV (7)

IL Receptor (7)

Epigenetic Reader Domain (7)

Akt (7)

TNF (7)

ALK (7)

HDAC (7)

MMP (7)

Estrogen/progestogen Receptor (7)

PI3K (7)

Nrf2 (6)

Microtubule Associated (6)

Adrenergic Receptor (6)

5-HT Receptor (6)

Sirtuin (6)

VEGFR (6)

Lipoxygenase (5)

mTOR (5)

GABA Receptor (5)

Xanthine Oxidase (5)

c-Met/HGFR (5)

Histone Demethylase (5)

STAT (5)

JAK (5)

SARS-CoV (5)

HSP (5)

OXPHOS (5)

VDAC (5)

NOS (5)

Carbonic Anhydrase (4)

PKC (4)

DUB (4)

IκB/IKK (4)

Myosin (4)

FLT (3)

P-gp (3)

Beta Amyloid (3)

Anti-infection (3)

RAAS (3)

Reverse Transcriptase (3)

PDGFR (3)

ERK (3)

Tyrosinase (3)

Dynamin (3)

JNK (3)

TLR (3)

Estrogen Receptor/ERR (3)

Cysteine Protease (3)

Hexokinase (3)

Trk receptor (3)

HIF (3)

E1/E2/E3 Enzyme (3)

Dopamine Receptor (3)

Wnt/beta-catenin (3)

CDK (3)

Free radical scavengers (3)

Gamma-secretase (3)

AChE (3)

NOD (2)

Prostaglandin Receptor (2)

Antiviral (2)

Kinesin (2)

p97 (2)

Imidazoline Receptor (2)

CFTR (2)

RSV (2)

Transferase (2)

Monocarboxylate transporter (2)

Integrin (2)

Phospholipase (2)

HMG-CoA Reductase (2)

ROR (2)

Complement System (2)

AChR (2)

Platelet aggregation (2)

c-Kit (2)

Tyrosine Kinases (2)

Proteasome (2)

IRE1 (2)

Hedgehog/Smoothened (2)

Glucocorticoid Receptor (2)

IAP (2)

Immunology/Inflammation related (2)

Histamine Receptor (2)

IGF-1R (2)

Opioid Receptor (2)

DNA (2)

ABC (2)

Guanylate cyclase (2)

Drug Metabolite (2)

HBV (2)

TOPK (2)

Interleukin (2)

TGF-beta/Smad (2)

EGFR (2)

SGLT (2)

Nucleoside Antimetabolite/Analog (2)

PKA (2)

Annexin A (1)

Syk (1)

Discoidin Domain Receptor (DDR) (1)

Adiponectin receptor (1)

UGT (1)

LDL (1)

P2X Receptor (1)

Gap Junction Protein (1)

IFNAR (1)

S6 Kinase (1)

Hydrogenase (1)

Phosphatase (1)

BMI-1 (1)

IRAK (1)

FGFR (1)

Ras (1)

Melatonin Receptor (1)

Thrombin (1)

TRP/TRPV Channel (1)

MRP (1)

CAT (1)

NOD-like Receptor (NLR) (1)

AhR (1)

Glucokinase (1)

Chloride channel (1)

NMDAR (1)

Antifection (1)

MEK (1)

RAR/RXR (1)

Casein Kinase (1)

DYRK (1)

GluCls (1)

Histone Acetyltransferase (1)

CaMK (1)

Aminopeptidase (1)

STING (1)

Mdm2 (1)

aconitase (1)

Lipid (1)

Acyltransferase (1)

ATP Citrate Lyase (1)

Na+/Ca2+ Exchanger (1)

Glutathione reductase (1)

Epoxide Hydrolase (1)

Somatostatin (1)

Src (1)

GPR (1)

HCV Protease (1)

Hydroxylase (1)

MAPK (1)

Glutathione Peroxidase (1)

MyD88 (1)

CRISPR/Cas9 (1)

Aromatase (1)

ATM/ATR (1)

Fatty Acid Synthase (1)

YAP (1)

Retinoid Receptor (1)

FAAH (1)

PTEN (1)

GST (1)

Adenosine Receptor (1)

Library Information Sample

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty