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SR33805

Catalog No. T8674 CAS 121345-64-0

SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)

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SR33805, CAS 121345-64-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 68.00
5 mg	In stock	$ 147.00
10 mg	In stock	$ 247.00
25 mg	In stock	$ 446.00
50 mg	In stock	$ 659.00
100 mg	In stock	$ 938.00
1 mL * 10 mM (in DMSO)	In stock	$ 183.00

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Purity: 98.94%

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Description	SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
Targets&IC50	Ca2+ channel, L-type:33 nM (EC50, in polarized conditions), Ca2+ channel, L-type:4.1 nM (EC50, in depolarized conditions)
In vitro	Acute treatment with SR33805 restored the MI-altered cell shortening without affecting the Ca(2+) transient amplitude, suggesting an increase of myofilament Ca(2+) sensitivity in MI myocytes.?Indeed, a SR33805-induced sensitization of myofilament activation was found to be associated with a slight increase in myosin light chain-2 phosphorylation and a more significant decrease on troponin I (TnI) phosphorylation.?Decreased TnI phosphorylation was related to inhibition of protein kinase A activity by SR33805.?Finally, administration of a single intra-peritoneal bolus of SR33805 (20 mg/kg) improved end-systolic strain and fractional shortening of MI hearts[1]

Molecular Weight	564.74
Formula	C32H40N2O5S
CAS No.	121345-64-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (48.69 mM)

References and Literature

1. Mou YA, et, al. Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res. 2011 Aug 1; 91(3): 412-9. 2. Romey G, et, al. Effects of two chemically related new Ca2+ channel antagonists, SR33557 (fantofarone) and SR33805, on the L-type cardiac channel. Eur J Pharmacol. 1994 Sep 22; 263(1-2): 101-5. 3. Hainaud P, et, al. The calcium inhibitor SR33805 reduces intimal formation following injury of the porcine carotid artery. Atherosclerosis. 2001 Feb 1; 154(2): 301-8.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Ion Channel Inhibitor Library Anti-Hypertension Compound Library Calcium Channel Compound Library Metabolism Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library Bioactive Compound Library

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Keywords

SR33805 121345-64-0 Membrane transporter/Ion channel Metabolism Calcium Channel Ca channels channel failing Ca2+ channels Ca2+ SR 33805 SR-33805 acute L-type Inhibitor inhibit depolarized polarized hearts chronic inhibitor

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