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Tetrandrine

Catalog No. T2996 CAS 518-34-3

Synonyms: NSC-77037, d-Tetrandrine, Hanfangchin A, Fanchinine, Sinomenine A

Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects.

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Tetrandrine, CAS 518-34-3

Pack Size	Availability	Price/USD
100 mg	In stock	$ 43.00
500 mg	In stock	$ 89.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.72%

Purity: 99.61%

Purity: 98.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects.
In vitro	In mice, the LD50 of Tetrandrine administrated via intravenous injection is 158.9 mg/kg, and when administered via intraperitoneal injection, the LD50 is 365 mg/kg. In rats, the LD50 of Tetrandrine administered via oral gavage is 646 mg/kg.
In vivo	In isolated rat pituitary nerve terminals, Tetrandrine inhibits voltage-gated Ca2+ currents (IC50=10.1 mM) and acts as a high-affinity blocker of the type II maxi-Ca(2+)-activated K+ channels (IC50=0.21 mM) present in these terminals. Moreover, Tetrandrine can suppress Ca(2+)-activated Cl- currents (IC50=5.2 mM). Additionally, in human leukemia HL-60 cells, Tetrandrine is capable of inhibiting cell proliferation and inducing apoptosis.
Source	Natural Products > Menispermaceae > Stephania

Synonyms	NSC-77037, d-Tetrandrine, Hanfangchin A, Fanchinine, Sinomenine A
Molecular Weight	622.75
Formula	C38H42N2O6
CAS No.	518-34-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.2 mM

References and Literature

1. Wang G, et al. Pflugers Arch, 1992, 421(6), 558-565. 2. Fang QZ, et al. Acta Pharmacol Sin, 2004, 25(3), 327-333. 3. Dong Y, et al. Life Sci, 1997, 60(8), PL135-140.

Citations

1. Zhang Q, Wu Y, Yu Y, et al. Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis. Frontiers in Bioengineering and Biotechnology. 2022, 10 2. Song J, Xu J, Guo J, et al. The enhancement of Tetrandrine to gemcitabine-resistant PANC-1 cytochemical sensitivity involves the promotion of PI3K/Akt/mTOR-mediated apoptosis and AMPK-regulated autophagy. Acta Histochemica. 2021, 123(6): 151769.

Related compound libraries

This product is contained In the following compound libraries：

Antiparasitic Natural Product Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library

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Pinacidil Myomodulin Tannic acid Acetohexamide Flufenamic acid Nifekalant hydrochloride Pimozide Amsacrine

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Keywords

Tetrandrine 518-34-3 Membrane transporter/Ion channel Metabolism Calcium Channel Potassium Channel Ca channels NSC-77037 KcsA NSC 77037 d-Tetrandrine Hanfangchin A NSC77037 Ca2+ channels inhibit Inhibitor Fanchinine Sinomenine A inhibitor

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