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Tetrandrine

Name: Tetrandrine
Brand: TargetMol
SKU: T2996
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2996Cas No. 518-34-3

Alias Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-Tetrandrine

Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.

Tetrandrine

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Purity: 99.94%

Catalog No. T2996Alias Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-TetrandrineCas No. 518-34-3

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$43	In Stock	In Stock
500 mg	$89	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Tetrandrine (Sinomenine A) is a naturally occurring biphenylisoquinoline alkaloid, a calcium channel inhibitor. Tetrandrine inhibits voltage-gated calcium channels (ICa) and Ca2+-activated potassium channels.
In vitro	METHODS: Leukemia cell lines K562, THP-1, U937, and HL60 were treated with Tetrandrine (1-3 µM) for 24-72 h, and cell numbers were measured. RESULTS: 2 µM and 3 µM Tetrandrine significantly inhibited cell proliferation. [1] METHODS: A panel of GFP-LC3-expressing tumor cell lines MCF-7, PLC-5, SK-Hep1, HeLa, and PC3 cells were treated with Tetrandrine (5 µM) for 16 h and GFP-LC3 spots were detected. RESULTS: Tetrandrine significantly induced GFP-LC3 spot formation with similar potency (5 µM) in all cell lines tested.Tetrandrine induced autophagy in multiple cell lines. [2]
In vivo	METHODS: To detect anti-tumor activity in vivo, athymic nude mice bearing THP-1 xenografts were administered Tetrandrine (25-50 mg/kg, 0.5% methylcellulose) by gavage once daily for 13 days. RESULTS: Tetrandrine treatment reduced tumor growth. [1]
Synonyms	Sinomenine A, NSC-77037, Hanfangchin A, Fanchinine, d-Tetrandrine

Chemical Properties

Molecular Weight	622.75
Formula	C₃₈H₄₂N₂O₆
Cas No.	518-34-3
Smiles	O(C)C1=C2C=3[C@](CC=4C=C(C(OC)=CC4)OC=5C=CC(C[C@]6(C7=CC(O2)=C(OC)C=C7CCN6C)[H])=CC5)(N(C)CCC3C=C1OC)[H]
Relative Density.	1.17 g/cm3 (20°C)

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 12.45 mg/mL (19.99 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 0.7 mg/mL (1.12 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6058 mL	8.0289 mL	16.0578 mL	80.2890 mL
5 mM	0.3212 mL	1.6058 mL	3.2116 mL	16.0578 mL
10 mM	0.1606 mL	0.8029 mL	1.6058 mL	8.0289 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc