Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
Description | Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM). |
Targets&IC50 | nicotinic receptor:59.6 μM |
In vitro | Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL. [1] Catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine. Catharanthine binds to tubulin alpha-beta dimer with binding constant of 2.8 mM. [2] Catharanthine stimulates release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. Catharanthine induces a delayed release of Ca2+ from prelabeled pancreatic fragments as compared to bethanechol. [3] Catharanthine inhibits epibatidine-induced Ca(2+) influx in TE671-α, -β, -γ, -δ cells in a noncompetitive manner with similar potencies IC50 of 17 mM-25 mM. Catharanthine inhibits [3H]TCP binding to the desensitized Torpedo AChR with higher affinity compared to the resting AChR. Catharanthine enhances [3H]cytisine binding to resting but activatable Torpedo AChRs, suggesting desensitizing properties. [4] |
Synonyms | (+)-3,4-Didehydrocoronaridine, 长春质碱, (+)-3, 4-Didehydrocoronaridine |
Molecular Weight | 336.435 |
Formula | C21H24N2O2 |
CAS No. | 2468-21-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Ethanol: 1 mg/mL(3 mM)
DMSO: 62 mg/mL (184.3 mM)
H2O: <1 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Catharanthine 2468-21-5 代谢 离子通道 神经科学 AChR Calcium Channel (+)-3, 4-Didehydrocoronaridine (+)-3,4-Didehydrocoronaridine Ca2+ channels Ca channels Inhibitor inhibit inhibitor