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Catharanthine

Catalog No. T2782 CAS 2468-21-5

Synonyms: (+)-3,4-Didehydrocoronaridine, 长春质碱, (+)-3, 4-Didehydrocoronaridine

Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).

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Catharanthine, CAS 2468-21-5

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Purity: 98%

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Description	Catharanthine suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
Targets&IC50	nicotinic receptor:59.6 μM
In vitro	Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL. [1] Catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine. Catharanthine binds to tubulin alpha-beta dimer with binding constant of 2.8 mM. [2] Catharanthine stimulates release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. Catharanthine induces a delayed release of Ca2+ from prelabeled pancreatic fragments as compared to bethanechol. [3] Catharanthine inhibits epibatidine-induced Ca(2+) influx in TE671-α, -β, -γ, -δ cells in a noncompetitive manner with similar potencies IC50 of 17 mM-25 mM. Catharanthine inhibits [3H]TCP binding to the desensitized Torpedo AChR with higher affinity compared to the resting AChR. Catharanthine enhances [3H]cytisine binding to resting but activatable Torpedo AChRs, suggesting desensitizing properties. [4]

Synonyms	(+)-3,4-Didehydrocoronaridine, 长春质碱, (+)-3, 4-Didehydrocoronaridine
Molecular Weight	336.435
Formula	C21H24N2O2
CAS No.	2468-21-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 1 mg/mL(3 mM)

DMSO: 62 mg/mL (184.3 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Pereira DM, et al. Phytomedicine, 2010, 17(8-9), 646-652. 2. Prakash V, et al. Biochemistry, 1991, 30(3), 873-880. 3. Williams JA, et al. Cell Tissue Res, 1978, 192(2), 277-284. 4. Arias HR, et al. Neurochem Int, 2010, 57(2), 153-161.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS Anti-Tumor Natural Product Library

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Keywords

Catharanthine 2468-21-5 代谢离子通道神经科学 AChR Calcium Channel (+)-3, 4-Didehydrocoronaridine (+)-3,4-Didehydrocoronaridine Ca2+ channels Ca channels Inhibitor inhibit inhibitor

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