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Catharanthine

Catharanthine
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Purity:99.55%
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Catharanthine

Catalog No. T2782Cas No. 2468-21-5
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
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Pack SizePriceAvailabilityQuantity
50 mg$39In Stock
100 mg$57In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Bioactivity
Description
Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).
In vitro
Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL. [1] Catharanthine can induce the self-association of tubulin into linear indefinite polymers with an efficacy that is 75% that of vinblastine or vincristine. Catharanthine binds to tubulin alpha-beta dimer with binding constant of 2.8 mM. [2] Catharanthine stimulates release of amylase from pancreatic fragments and to cause extensive degranulation of pancreatic acinar cells with accumulation of membrane material in the Golgi region. Catharanthine induces a delayed release of Ca2+ from prelabeled pancreatic fragments as compared to bethanechol. [3] Catharanthine inhibits epibatidine-induced Ca(2+) influx in TE671-α, -β, -γ, -δ cells in a noncompetitive manner with similar potencies IC50 of 17 mM-25 mM. Catharanthine inhibits [3H]TCP binding to the desensitized Torpedo AChR with higher affinity compared to the resting AChR. Catharanthine enhances [3H]cytisine binding to resting but activatable Torpedo AChRs, suggesting desensitizing properties. [4]
Alias(+)-3, 4-Didehydrocoronaridine, (+)-3,4-Didehydrocoronaridine
Chemical Properties
Molecular Weight336.43
FormulaC21H24N2O2
Cas No.2468-21-5
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 1 mg/mL(3 mM)
DMSO: 62 mg/mL (184.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM2.9724 mL14.8619 mL29.7239 mL148.6193 mL
DMSO
1mg5mg10mg50mg
5 mM0.5945 mL2.9724 mL5.9448 mL29.7239 mL
10 mM0.2972 mL1.4862 mL2.9724 mL14.8619 mL
20 mM0.1486 mL0.7431 mL1.4862 mL7.4310 mL
50 mM0.0594 mL0.2972 mL0.5945 mL2.9724 mL
100 mM0.0297 mL0.1486 mL0.2972 mL1.4862 mL

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