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Hirsutine

Catalog No. TN1065 CAS 7729-23-9

Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.

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Hirsutine, CAS 7729-23-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 128.00
10 mg	In stock	$ 228.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 139.00

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Purity: 99.36%

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Description	Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.
In vitro	The clinical utility of Hirsutine against human breast cancer. Among six distinct human breast cancer cell lines, Hirsutine showed strong cytotoxicity against HER2-positive/p53-mutated MDA-MB-453 and BT474 cell lines. Conversely, HER2-negative/p53 wild-type MCF-7 and ZR-75-1 cell lines showed resistance against Hirsutine-induced cytotoxicity. Hirsutine induced apoptotic cell death in the MDA-MB-453 cells, but not in the MCF-7 cells, through activation of caspases. Furthermore, Hirsutine induced the DNA damage response in the MDA-MB-453 cells, but not in the MCF-7 cells, as highlighted by the upregulation of γH2AX expression. Along with the induction of the DNA damage response, the suppression of HER2, NF-κB and Akt pathways and the activation of the p38 MAPK pathway in the MDA-MB-453 cells were observed[1]
Source	Natural Products > Rubiaceae > Uncaria

Molecular Weight	368.47
Formula	C22H28N2O3
CAS No.	7729-23-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (135.7 mM)

References and Literature

1. Selective anticancer activity of hirsutine against HER2-positive breast cancer cells by inducing DNA damage.Oncol Rep. 2015 Apr;33(4):2072-6.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Miao medicine Compound Library Anti-Cancer Active Compound Library Alkaloid Natural Product Library Covalent Inhibitor Library Anti-Viral Compound Library Anti-Gastroenteritis Natural Product Library Anti-Cancer Compound Library The Yao nationality medicine Library Anti-Tumor Natural Product Library

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Keywords

Hirsutine 7729-23-9 Apoptosis inhibit Inhibitor inhibitor

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