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FPL64176

Catalog No. T22788 CAS 120934-96-5

Synonyms: FPL 64176

FPL64176 is a L-type calcium channels activator.

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FPL64176, CAS 120934-96-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 36.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 278.00
50 mg	In stock	$ 513.00
100 mg	In stock	$ 747.00
500 mg	In stock	$ 1,560.00
1 mL * 10 mM (in DMSO)	In stock	$ 94.00

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Purity: 97.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FPL64176 is a L-type calcium channels activator.
In vitro	FPL-64176, on schistosomes cultured ex vivo and in an in vivo murine model of infection.?Unlike DHPs, FPL-64176 evokes rapid and sustained contractile paralysis of adult Schistosoma mansoni reminiscent of the anthelmintic praziquantel.?This is accompanied by tegument disruption and an arrest of mitotic activity in somatic stem cells and germ line tissues.?Interestingly, this strong ex vivo phenotype was temperature dependent, with FPL-64176 treatment being less potent at 37 C than 23 C. However, FPL-64176 caused intra-tegument lesions at the basement membrane of worms cultured ex vivo under both conditions,?as well as an in vivo hepatic shift of parasites from the mesenteric vasculature of infected mice to the liver[1].
In vivo	Gene expression profiling of worms harvested following in vivo FPL-64176 exposure reveals differences in transcripts associated with muscle and extracellular matrix function, as well as female reproduction, which is consistent with the worm phenotypes observed following ex vivo drug treatment[1].

Synonyms	FPL 64176
Molecular Weight	347.41
Formula	C22H21NO3
CAS No.	120934-96-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (158.31 mM)

References and Literature

1. Mccusker P , Chan J D . Anti-schistosomal action of the calcium channel agonist FPL-64176[J]. International Journal for Parasitology: Drugs and Drug Resistance, 2019, 11. 2. Wang, Yuchen, Tang, et al. Molecular Determinants of the Differential Modulation of Ca(v)1.2 and Ca(v)1.3 by Nifedipine and FPL 64176[J]. Molecular Pharmacology, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Hypertension Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library Bioactive Compound Library Metabolism Compound Library Calcium Channel Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FPL64176 120934-96-5 Membrane transporter/Ion channel Metabolism Calcium Channel Ca2+ channels FPL 64176 inhibit Inhibitor Ca channels FPL-64176 inhibitor

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