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Cat No. | Product Name | Synonyms | Targets |
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T39965 | NF-κΒ activator 1 | NF-κB | |
NF-κΒ activator 1 can activate the nf-kappa Β gene activator, EC50 of 0.9 microns. NF-κΒ is widely used in eukaryotic cells as a gene regulating cell proliferation and cell survival. NF-κΒ activator 1 induces superoxide ... | |||
T39924 | NF-κΒ activator 2 | NF-κB | |
NF-κΒ Activator 2 is a potent, orally active compound that efficiently activates NF-κB with an EC50 value of 1.58 μM. By enhancing NF-κB expression and activation, it induces SOD 2 synthesis, rendering it useful for amyo... | |||
T9656 | AP-1/NF-κB activation inhibitor 1 | NF-κB , DNA/RNA Synthesis | |
AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation in... | |||
T9105 | NF-κB-IN-1 | 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- | IκB/IKK , NF-κB |
NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir... | |||
T27620 | IP7e | IP 7e,IP-7e,isoxazolo-pyridinone 7e | Others |
IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM. | |||
T37559 | NF-κB Control | ||
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It bloc... | |||
T38153 | NF-κB Inhibitor (trifluoroacetate salt) | ||
NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the... | |||
T60357 | NF-κB-IN-2 | JEUD-38 | |
NF-κB-IN-2 inhibits canonical NF-κB signaling induced by TNF-α in PC-3 cells. | |||
T20168 | Aurothiomalate sodium | Myocrisin,Myocrisine,Miochrysin,Sodium aurothiomalate,Myochrysine,gold sodium thiomalate | Others , PKC |
Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate ... | |||
T4543 | Telithromycin | HMR3647,Ketek,RU66647 | Antibacterial , Antibiotic |
Telithromycin (HMR3647) is a ketolide antibiotic to treat community acquired pneumonia of mild to moderate severity. Antibacterial Telithromycin prevents bacteria from growing, by interfering with their protein synthesis... | |||
T4361 | CBL0137 hydrochloride | CBL0137,CBLC137,Curaxin 137,CBL-C137 hydrochloride,Curaxin-137 hydrochloride | Others , NF-κB , p53 |
CBL0137 hydrochloride (Curaxin-137 hydrochloride) activates p53 and inhibits NF-kB (EC50: 0.37/0.47 μM) in the cell-based p53 and NF-kB reporter assays, respectively. It also suppresses histone chaperone FACT. | |||
T21480 | Diethylmaleate | Maleic acid, diethyl ester,DIETHYL MALEATE | NF-κB |
Diethylmaleate (Maleic acid, diethyl ester) is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. | |||
T8981 | WAY-169916 | WAY 169916,WAY169916 | NF-κB |
WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity. | |||
T8951 | JTP 0819958 - HOIPIN-1 | IκB/IKK | |
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2]. | |||
T78557 | HOIPIN-1 | JTP0819958 | NF-κB |
HOIPIN-1 (JTP0819958) is a selective and potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) (IC50 >2.8 μM).HOIPIN-1 inhibits LUBAC-mediated NF-kB activation. | |||
TP1615L | IKKγ NBD Inhibitory Peptide acetate | IKKγ NBD Inhibitory Peptide acetate(372146-18-4 free base) | NF-κB |
IKKγ NBD Inhibitory Peptide acetate is a NEMO-binding domain peptide (NBD peptide) acetate corresponding to the NEMO amino-terminal alpha-helical region. IKKγ NBD Inhibitory Peptide acetate is shown to block TNF-alpha-in... | |||
T22115 | SM-7368 | NF-κB | |
The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications. | |||
T0947 | Dexamethasone acetate | Dexamethasone 21-acetate,Dexamethason acetate,NSC 39471 | Glucocorticoid Receptor , Mitophagy , IL Receptor , Annexin A , NOS , Antibacterial , Autophagy |
Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexa... | |||
T0005 | Aspirin | Acetylsalicylate,Acetylsalicylic Acid,ASA | Mitophagy , Virus Protease , COX , Autophagy |
Aspirin (Acetylsalicylic Acid) is a potent and selective inhibitor of COX with various pharmacological activities, such as anti-inflammation and pain relief. Aspirin is a histone deacetylase inhibitors to up-regulate cel... | |||
T11096 | DRI-C21045 | NF-κB | |
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. IC50 was 17.1 M and 4.5 M, respectively.Dri-c21045 is an effective selective inhibitor of CD40-CD40L... | |||
T11886 | LTβR-IN-1 | Others , NF-κB , LTR | |
LTβR-IN-1 is a potent and selective lymphin β receptor (LTβR) inhibitor. LTβR-IN-1 has a selective inhibitory effect on the nuclear translocation of p52 of TNF12A, and has no obvious effect on the nuclear translocation o... | |||
T5209 | INH14 | IκB/IKK | |
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ). | |||
T6964 | Resiquimod | R848,S28463 | HCV Protease , TLR |
Resiquimod (R848) is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect through the TLR signaling pathway by binding to and acti... | |||
T68729 | Coumaperine | ||
Coumaperine is an NF-kB inhibitor. | |||
T28065 | ML263 | ML-263,ML 263 | |
ML263 inhibits NF-kB activation induced by B-cell specific antigen receptor. | |||
T29013 | HE 3286 | Triolex,HE-3286,HE3286 | |
Triolex, an NF-kB inhibitor, is used potentially for the treatment of rheumatoid arthritis, ulcerative colitis. | |||
TP1615 | IKKγ NBD Inhibitory Peptide | ||
A cell-permeable synthetic peptide NEMO-binding domain peptide (NBD peptide) corresponding to the NEMO amino-terminal alpha-helical region is shown to block TNF-alpha-induced NF-kB activation. The interaction of IKγNEMO ... | |||
T63107 | Anti-inflammatory agent 6 | ||
Anti-inflammatory agent 6 exhibits anti-inflammatory potential by blocking the phosphorylation of Iκb kinase α/β (IKKα/β), IκBα and nuclear factor kB p65 (NF-κb p65), which are key controllers of inflammation. | |||
T62359 | TLR4/NF-κB/MAPK-IN-1 | ||
TLR4/NF-κB/MAPK-IN-1 is a novel antineuroinflammatory agent that functions by inhibiting the TLR4/NF-κB/MAPK pathways. | |||
T76024 | IKKγ NBD Inhibitory Peptide TFA | ||
IKKγ NBD Inhibitory Peptide TFA is a specific NF-κB inhibitor that functions by hindering the interaction between the IKKγ/NEMO-binding domain (NBD) and IKKα and IKKβ. This action effectively prevents TNF-α-induced NF-kB... | |||
T71827 | AG-205 | ||
(rac)-AG-205 serves as a robust inhibitor of the progesterone receptor membrane component 1 (Pgrmc1), crucial for inducing genes linked to sterol synthesis, notably the INSIG1 protein, which interacts with PGRMC1. Additi... | |||
T11240 | Ethacrynic acid D5 | Others | |
Ethacrynic acid, a diuretic, functions as an inhibitor of L-type voltage-dependent and store-operated calcium channels, facilitating the relaxation of airway smooth muscle (ASM) cells. It exhibits anti-inflammatory effec... | |||
T71285 | Metaxalone-d6 | ||
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264... | |||
T74895 | Anti-inflammatory agent 31 | ||
Anti-inflammatory agent 31 (enone 17), an andrographolide derivative, acts as an anti-inflammatory agent by inhibiting NF-κB activation through the upstream blockade of PI3K/Akt and ERK1/2 MAPK pathways. It effectively r... | |||
T37449 | SR 12460 | ||
SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits T... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2745 | 18α-Glycyrrhetinic acid | Enoxolone,Glycyrrhetinic acid | Apoptosis , NF-κB , Proteasome |
18α-Glycyrrhetinic acid (Enoxolone) is an inhibitor of NF-kB and an activator of the proteasome, and functions as a longevity-promoting and anti-aggregation factor in multicellular organisms. It induces apoptosis. | |||
T0335 | Sodium salicylate | Salicylic acid sodium salt,2-Hydroxybenzoic acid sodium salt | Apoptosis , NF-κB , COX , S6 Kinase , Autophagy |
Sodium salicylate (2-Hydroxybenzoic acid sodium salt), a metabolite of acetylsalicylic acid, can inhibit NF-kB and reduce oxidative stress. | |||
T3000 | Magnolol | NSC 293099,5,5'-Diallyl-2,2'-biphenyldiol | NF-κB , Retinoid Receptor , Antibacterial , PPAR , p53 , Autophagy |
Magnolol (5,5'-Diallyl-2,2'-biphenyldiol) is a dual agonist of RXRα( EC50=10.4 μM) and PPARγ(EC50=17.7 μM). It blocks TNF-α-induced NF-KB activation. | |||
T5727 | CAFESTOL | ERK , NF-κB , COX , PGE Synthase | |
CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production... | |||
T3S1692 | Octahydrocurcumin | Anti-infection , NF-κB , Reactive Oxygen Species , ROS | |
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahy... | |||
T5754 | Kavain | NF-κB , GABA Receptor | |
Kavain, a compound extracted from the Kava plant, Piper methysticum, is found to be involved in TNF-α expression in human and mouse cells via regulation of transcriptional factors such as NF-kB and LITAF. | |||
T5660 | Menthone | IL Receptor , TNF , NF-κB , Parasite | |
Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor k... | |||
TN6730 | Epoxyazadiradione | NF-κB | |
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. | |||
T3913 | Saikosaponin D | Estrogen Receptor/ERR , NF-κB , Antibacterial , STAT | |
Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity. | |||
T4S1540 | Myrislignan | Apoptosis , NF-κB | |
Myrislignan has anti-inflammatory, and anti-cancer activities, it inhibited NF-κB signalling pathway activation, inhibited the proliferation of A549 cells in a dose- and time-dependent manner, it also significantly induc... | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T7190 | Actein | Apoptosis , Akt , JNK , Autophagy | |
Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways in... | |||
T7979 | 2-Hydroxychalcone | 2-(2-Hydroxybenzal)Acetophenone | Apoptosis , BCL , Others , NF-κB |
2-Hydroxychalcone (2-(2-Hydroxybenzal)Acetophenone) can be used as antiparasitic hit compounds when Methoxylated.It can inhibit invasion of triple negative breast cancer cells. | |||
T5687 | WITHAFERIN A | Ferroptosis , NF-κB | |
WITHAFERIN A is a novel class of NFkappaB inhibitors, which hold promise as novel anti-inflammatory agents for treatment of various inflammatory disorders and/or cancer. | |||
T5S0761 | Nitidine chloride | Apoptosis , ERK , FAK , p38 MAPK , NF-κB , Topoisomerase , STAT , Parasite | |
1. Nitidine chloride has inhibitory effects on various tumors, such as renal cancer , breast cancer. 2. Nitidine chloride inhibits the proliferation of SMMC-7721 cells in vitro in a time- and dose-dependent manner and id... | |||
T4S0969 | Obtusifolin | Antioxidant , NF-κB | |
1. Obtusifolin has antioxidant properties and improves chemically induced diabetes and its complications by modulation of oxidative stress. 2. Obtusifolin suppresses phthalate esters-mediated bone resorption, thus may be... | |||
T83358 | 3-Ethylthio withaferin A | ||
3-Ethylthio withaferin A, a derivative of Withaferin A, is a compound known for its inhibitory action on NF-κB (NF-kB). | |||
TN1874 | Liriodendrin | ATPase , Potassium Channel , Prostaglandin Receptor | |
Liriodendrin regulates lung inflammation, the phosphorylation of the NF-kB (p65) and expression of vascular endothelial growth factor (VEGF). Liriodendrin has anti-inflammatory, antinociceptive, hypoglycemic activities a... | |||
TN3709 | Coronarin D ethyl ether | NF-κB | |
Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans ... | |||
T39077 | Aeruginosin 865 | ||
Aeruginosin 865, a compound extracted from the terrestrial cyanobacterium Nostoc sp. Luke ová 30/93, represents the inaugural aeruginosin-type peptide to incorporate a fatty acid and a carbohydrate moiety. It functions b... | |||
TN1104 | Cyanidin 3-sambubioside chloride | Cyanidin-3-O-sambubioside chloride | NF-κB , ROS |
Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant act... | |||
T75491 | 3-(2-Hydroxyethyl) thio withaferin A | ||
3-(2-Hydroxyethyl) thio withaferin A, a derivative of Withaferin A, is a steroidal lactone that inhibits NF-kB activation and targets vimentin, showcasing potent anti-inflammatory and anticancer properties. It also acts ... | |||
TN3219 | 7,8-Didehydrocimigenol | ERK , IκB/IKK , TNF , NF-κB , Akt , PPAR | |
7,8-Didehydrocimigenol can be used for the treatment of cardiovascular disorders such as atherosclerosis. It upregulates PPAR-γ in EC inhibits NF-kB activity of TNF-α-activated EC which leads to selective inhibition of V... | |||
TN4194 | Heliangin | IL Receptor , TNF , NF-κB , MAPK , Prostaglandin Receptor | |
Heliangin shows anti-inflammatory effects, it can inhibit lipopolysaccharide-induced inflammation through signaling NF-κB pathway on LPS-induced RAW 264.7 cells. Heliangin has anti-cancer activity, it exhibits cytotoxic... | |||
TN5153 | Torilin | MMP , ERK , IκB/IKK , p38 MAPK , NF-κB , Tyrosinase , Reductase , DNA/RNA Synthesis , JNK | |
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic acid (IC50 = 160.3 +/- 24.62 microM) but is weaker than fi... |
Cat No. | Product Name | Species | Expression System |
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TMPK-00723 | RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio... | |||
TMPY-02387 | NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST) | Human | E. coli |
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it fac... | |||
TMPK-00351 | RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) | Human | HEK293 Cells |
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in glio... | |||
TMPJ-00674 | RANK/TNFRSF11A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Receptor activator of NF-κB(RANK,TNFRSF11A) belongs to one member of tumor necrosis factor receptor family.It is a receptor for TNFSF11/RANKL/TRANCE/OPGL. This gene encodes a type 1 membrane protein with a 30 amino acid... | |||
TMPJ-00349 | RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) | Human | HEK293 Cells |
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANK... | |||
TMPY-01710 | IkB alpha/NFKBIA Protein, Human, Recombinant (His) | Human | E. coli |
Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NF... | |||
TMPJ-00464 | APE Protein, Human, Recombinant | Human | E. coli |
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete re... | |||
TMPY-01176 | CIAP1 Protein, Human, Recombinant (Avi) | Human | E. coli |
The cellular inhibitor of apoptosis protein-1 (cIAP1) is a member of the Inhibitor of Apoptosis family proteins are (IAP) whose members are characterized by a novel domain of about 70 amino acids termed baculoviral IAP r... | |||
TMPH-02169 | TRBC1 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pe... | |||
TMPH-02173 | TRBC2 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize pe... | |||
TMPH-02168 | TRAC Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Constant region of T cell receptor (TR) alpha chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize p... |
Cat No. | Product Name | ||
---|---|---|---|
L3800 | NF-κB Signaling Compound Library | 729 compounds | |
A unique collection of 729 compounds targeting NF-κB signaling for high throughput screening and high content screening; | |||
L3600 | Cytokine Inhibitor Library | 604 compounds | |
A unique collection of 604 compounds targeting cytokine signaling for high throughput screening and high content screening for drug discovery; | |||
L4700 | Immunology/Inflammation Compound Library | 4720 compounds | |
A unique collection of 4720 anti-inflammation compounds effective for high throughput screening and high content screening. |