Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 239.00 | |
10 mg | In stock | $ 428.00 | |
25 mg | In stock | $ 686.00 | |
50 mg | In stock | $ 969.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 283.00 |
Description | Epoxyazadiradione is an extract from Neem (Azadirachta indica) plant and may induce mitochondrial apoptosis and inhibition of NF-kB in human cervical cancer cells. |
In vitro | Epoxyazadiradione exhibits most potent anti-cancer activity in both TNBC and ER+ breast cancer cells.?Epoxyazadiradione induces apoptosis and inhibits PI3K/Akt-mediated mitochondrial potential, cell viability, migration and angiogenesis.?It also inhibits the expression of pro-angiogenic and pro-metastatic genes such as Cox2, OPN, VEGF and MMP-9 in these cells.?Furthermore, epoxyazadiradione attenuates PI3K/Akt-mediated AP-1 activation.Epoxyazadiradione suppresses breast tumor growth and angiogenesis in orthotopic NOD/SCID mice model. |
Molecular Weight | 466.57 |
Formula | C28H34O6 |
CAS No. | 18385-59-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (128.6 mM)
You can also refer to dose conversion for different animals. More
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Epoxyazadiradione 18385-59-6 NF-Κb NF-κB huMIF Parasite Inhibitor proinflammatory MIF limonoid inhibit parasites inhibitor