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WAY-169916

Catalog No. T8981   CAS 669764-18-5
Synonyms: WAY 169916, WAY169916

WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.

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WAY-169916 Chemical Structure
WAY-169916, CAS 669764-18-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 41.00
5 mg In stock $ 97.00
10 mg In stock $ 163.00
25 mg In stock $ 347.00
50 mg In stock $ 578.00
100 mg In stock $ 833.00
500 mg In stock $ 1,690.00
1 mL * 10 mM (in DMSO) In stock $ 143.00
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Purity: 98.44%
Purity: 98.37%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER). It acts by inhibiting NF-kB transcriptional activity but being devoid of conventional estrogenic activity.
Synonyms WAY 169916, WAY169916
Molecular Weight 334.29
Formula C17H13F3N2O2
CAS No. 669764-18-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/ml (164.53 mM)

TargetMolReferences and Literature

1. Liu Z, Wang L, Tan H, Zhou S, Fu T, Xia Y, Zhang Y, Wang J. Synthesis of 1H-indazoles from N-tosylhydrazones and nitroaromatic compounds. Chem Commun (Camb). 2014 May 21;50(39):5061-3. doi: 10.1039/c4cc00962b. Epub 2014 Apr 9. PubMed PMID: 24714999. 2. Gao L, Tu Y, Ågren H, Eriksson LA. Characterization of agonist binding to His524 in the estrogen receptor α ligand binding domain. J Phys Chem B. 2012 Apr 26;116(16):4823-30. doi: 10.1021/jp300895g. Epub 2012 Apr 17. PubMed PMID: 22482773. 3. Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Coupling of receptor conformation and ligand orientation determine graded activity. Nat Chem Biol. 2010 Nov;6(11):837-43. doi: 10.1038/nchembio.451. Epub 2010 Oct 10. PubMed PMID: 20924370; PubMed Central PMCID: PMC2974172. 4. Murray IA, Krishnegowda G, DiNatale BC, Flaveny C, Chiaro C, Lin JM, Sharma AK, Amin S, Perdew GH. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17;23(5):955-66. doi: 10.1021/tx100045h. PubMed PMID: 20423157; PubMed Central PMCID: PMC2871980.

Related compound libraries

This product is contained In the following compound libraries:
Antioxidant Compound Library Oxidation-Reduction Compound Library Anti-Lung Cancer Compound Library Transcription Factor-Targeted Compound Library Pyroptosis Compound Library Anti-Prostate Cancer Compound Library Anti-Cancer Compound Library Inhibitor Library Bioactive Compound Library Anti-Ovarian Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WAY-169916 669764-18-5 NF-Κb NF-κB Inhibitor Nuclear factor-kappaB inhibit Estrogen Receptor/ERR WAY 169916 WAY169916 Nuclear factor-κB inhibitor

 

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