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Octahydrocurcumin

Catalog No. T3S1692   CAS 36062-07-4

Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity.

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Octahydrocurcumin Chemical Structure
Octahydrocurcumin, CAS 36062-07-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 66.00
5 mg In stock $ 153.00
10 mg In stock $ 226.00
25 mg In stock $ 379.00
50 mg In stock $ 563.00
1 mL * 10 mM (in DMSO) In stock $ 167.00
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Purity: 99.54%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity.
In vitro OKT3-induced PBMC proliferation was inhibited by curcumin, isocurcumin, bisdesmethoxy-, diacetyl-, tetrahydro-, hexahydro-, and octahydrocurcumin as well as by vanillin, ferulic acid, and dihydroferulic acid with IC50-values of 2.8, 2.8, 6.4, 1.0, 25, 38, 82, 729, 457, and >1,000?μM, respectively. The investigated substances with the strongest effect on radical scavenging were tetrahydro-, hexahydro-, and octahydrocurcumin with IC50?values of 10.0, 11.7, and 12.3?μM, respectively. IC50-values of dihydroferulic acid, ferulic acid, and curcumin were 19.5, 37, and 40?μM. The substances with the lowest radical scavenging activities were vanillin, isocurcumin, diacetylcurcumin, and bisdesmethoxycurcumin with IC50?values higher than 100?μM each[1].
Source
Molecular Weight 376.44
Formula C21H28O6
CAS No. 36062-07-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 10 mg/mL (26.56 mM), sonification is recommended.

DMSO: 100 mg/mL (265.65 mM), sonification is recommended.

TargetMolReferences and Literature

1. Different Curcuminoids Inhibit T-Lymphocyte Proliferation Independently of Their Radical Scavenging Activities. Pharmaceutical Research,2008, 25,(8):1822-7. 2. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol.Pharm. Bull., 2007, 30(1):74-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Liver Cancer Compound Library Antidepressant Compound Library Kinase Inhibitor Library Traditional Mongolian Medicine Compound Library Polyphenolic Natural Product Library Anti-infective Natural Product Library Transcription Factor-Targeted Compound Library Chinese Pharmacopoeia Natural Product Library Mitochondria-Targeted Compound Library Anti-Lung Cancer Compound Library

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Keywords

Octahydrocurcumin 36062-07-4 Immunology/Inflammation Metabolism Microbiology/Virology NF-Κb Anti-infection NF-κB Reactive Oxygen Species ROS Hexahydrobisdemethoxycurcumin inhibit Inhibitor inhibitor

 

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