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NF-κB Inhibitor (trifluoroacetate salt)

Catalog No. T38153

NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

NF-κB Inhibitor (trifluoroacetate salt) Chemical Structure

NF-κB Inhibitor (trifluoroacetate salt), CAS N/A

Pack Size	Availability	Price/USD
500 μg	35 days	$ 168.00
1 mg	35 days	$ 320.00
5 mg	35 days	$ 1,310.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight

N/A

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 30 mg/mL

PBS (pH 7.2): 5 mg/mL

DMSO: 30 mg/mL

Ethanol: 50 mg/mL

References and Literature

1. Lin, Y.Z., Tao, S., Veach, R.A., et al.Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceJ. Biol. Chem.270(24)14255-14258(1995) 2. Torgerson, T.R., Colosia, A.D., Donahue, J.P., et al.Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50Journal of Immunology161(11)6084-6092(1998) 3. Kasibhatla, S., Genestier, L., and Green, D.R.Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κBThe Journal of Biological Chemisty274(2)987-992(1999) 4. Methot, L., Hermann, R., Tang, Y., et al.Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesisMolecular and Cellular Biology33(14)2797-2808(2013) 5. W?ster, P., Rosdahl, I., and ?linger, K.Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet BBritish Journal of Dermatology171(6)1336-1346(2014)

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You can also refer to dose conversion for different animals. More

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

NF-κB Inhibitor (trifluoroacetate salt) NF-κB Inhibitor NF-kB Inhibitor NFκB Inhibitor (trifluoroacetate salt) NF-kappaB Inhibitor NF κB Inhibitor (trifluoroacetate salt) inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.