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Dexamethasone acetate

Catalog No. T0947   CAS 1177-87-3
Synonyms: Dexamethasone 21-acetate, Dexamethason acetate, NSC 39471

Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.

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Dexamethasone acetate Chemical Structure
Dexamethasone acetate, CAS 1177-87-3
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 g In stock $ 77.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.22%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dexamethasone acetate (NSC 39471) is the acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.
In vitro Dexamethasone inhibits COX-2 mRNA expression induced by IL-1 in human articular chondrocytes. [1] Dexamethasone suppresses the cyclooxygenase-2 induction by tumor necrosis factor α (TNFα) with an IC50 of 1 nM in MC3T3-E1 cells. Dexamethasone binds to the glucocorticoid receptor and then to the glucocorticoid response element. [2]Dexamethasone (10 μM) induces osteoblastic differentiation of rat bone marrow stromal cell cultures with elevated mRNA expression of alkaline phosphatase osteopontin, bone sialoprotein, and osteocalcin. [3] Dexamethasone (5 μM) treatment decreases proliferation of adult hippocampal neural progenitor cells and SRE-driven gene expression. [5]
In vivo Dexamethasone (2 mg/kg) reduces the number of the BrdU-labeled hepatocytes by 80% in male Fischer F344 rats. Dexamethasone (2 mg/kg) pretreatment suppresses the expression of both TNF and IL-6 after partial hepatectomy and significantly reduces the proliferative response of the hepatocytes in male Fischer F344 rats. Dexamethasone also severely diminishes the induction and expansion of oval cells induced by the 2-acetylaminofluorene/partial hepatectomy (AAF/PH) protocol but does not have any effect on the proliferation of the bile duct cells stimulated by bile duct ligation. [4] Dexamethasone (100 μg/kg) produces a significant decrease 59.2% of BrdU(+) hippocampal progenitor cells in Sprague–Dawley rats. Dexamethasone (100 μg/kg) decreases ERK activation in granule cell layer in Sprague–Dawley rats. [5]
Synonyms Dexamethasone 21-acetate, Dexamethason acetate, NSC 39471
Molecular Weight 434.5
Formula C24H31FO6
CAS No. 1177-87-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 16 mg/mL (36.8 mM)

DMSO: 81 mg/mL (186.4 mM)

TargetMolReferences and Literature

1. Rickard DJ, et al. Dev Biol, 1994, 161(1), 218-228. 2. Nagy P, et al. Hepatology, 1998, 28(2), 423-429. 3. Kim JB, et al. Brain Res, 2004, 1027(1-2), 1-10. 4. Wu CY, et al. J Immunol. 1998, 161(6), 2723-2730. 5. Blanco FJ, et al. J Rheumatol, 1999, 26(6), 1366-1373.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Approved Drug Library Cuproptosis Compound Library Pyroptosis Compound Library Target-Focused Phenotypic Screening Library FDA-Approved & Pharmacopeia Drug Library Anti-Viral Compound Library Anti-Metabolism Disease Compound Library

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Keywords

Dexamethasone acetate 1177-87-3 Autophagy Endocrinology/Hormones GPCR/G Protein Immunology/Inflammation Microbiology/Virology Antibacterial Glucocorticoid Receptor Mitophagy IL Receptor Annexin A NOS Inhibitor factor-AT nuclear NSC-39471 factor-kB lipopolysaccharide Dexamethasone protein-1 Dexamethasone 21-acetate key Dexamethasone Acetate Dexamethason Acetate NSC39471 Bacterial (LPS)-induced inhibit genes Dexamethason acetate Hexadecadrol inflammation NSC 39471 Mitochondrial Autophagy inhibitor

 

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