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Actein

Catalog No. T7190 CAS 18642-44-9

Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-kB and MEK pathways.

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Actein, CAS 18642-44-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 147.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 493.00
25 mg	In stock	$ 789.00
50 mg	In stock	$ 1,070.00
1 mL * 10 mM (in DMSO)	In stock	$ 439.00

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Description	Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis, it also can prevent oxidative damage to osteoblasts in osteoporotic patients. Actein's ability to pathways involved in lipid disorders and carcinogenesis may make it a new agent for preventing and treating these major disorders, it has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-kB and MEK pathways.
In vitro	Actein, isolated from black cohosh, was subjected to in vitro experiments to investigate its functional bioactivities in osteoblastic MC3T3-E1 cells. METHODS AND RESULTS: Actein caused a significant elevation of alkaline phosphatase activity, collagen synthesis, osteocalcin production, mineralization, and glutathione content in the cells, suggesting that Actein has a stimulatory effect on osteoblastic bone formation or has potential activity against osteoporosis. We investigated the protective effects of Actein on mitochondrial electron transport inhibitor, antimycin A induced toxicity in osteoblastic MC3T3-E1 cells. Exposure of MC3T3-E1 cells to antimycin A caused significant decrease in cell viability and mineralization. However, pretreatment with Actein prior to antimycin A exposure significantly reduced antimycin A-induced cell damage by preventing mitochondrial membrane potential dissipation, complex IV inactivation, cardiolipin oxidation, ROS release, and nitrotyrosine increase, suggesting that Actein may be useful for protecting mitochondria against a burst of oxidative stress. In addition, Actein increased the phosphorylation of CREB (cAMP-response element-binding protein) inhibited by antimycin A and decreased the production of TNF-α induced by antimycin A. CONCLUSIONS:These findings suggest that Actein could prevent oxidative damage to osteoblasts in osteoporotic patients.
Source	Natural Products > Ranunculaceae > Cimicifuga

Molecular Weight	676.83
Formula	C37H56O11
CAS No.	18642-44-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (88.64 mM)

References and Literature

1. Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells. J Med Food. 2014 Apr;17(4):414-23.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Natural Product Library Anti-Pancreatic Cancer Compound Library Anti-Ovarian Cancer Compound Library NO PAINS Compound Library HIF-1 Signaling Pathway Compound Library Human Metabolite Library Anti-Cancer Compound Library Neural Regeneration Compound Library Oxidation-Reduction Compound Library

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Keywords

Actein 18642-44-9 Apoptosis Autophagy Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling JNK Akt PKB Inhibitor inhibit Protein kinase B inhibitor

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