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Search Result

Search Results for " mdm-2/p53 "

Targets

Sirtuin

59

Compounds

2

Natural Products

292

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T1887 Inauhzin INZ Sirtuin
Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A54...
T16523L PhiKan 083 Mdm2
PhiKan 083 is a carbazole derivative
T21578 NSC 66811 Mdm2
NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53...
T1873 Tenovin-3 Tenovin3 Sirtuin
Tenovin-3 acts as a p53 activator.
T8774 MS7972 Epigenetic Reader Domain
MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
T2464 ZMC1 p53
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
T6910 NSC59984 p53
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
T27029 Cjoc42 cjoc 42,cjoc-42
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w...
T6610 XI-006 NSC 207895 Mdm2 , p53
XI-006 (XI-006) suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.
T12257 NSC 146109 hydrochloride Apoptosis , Others
NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.
T9698 UC2288 Mdm2 , p53
UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.
T7703 PK11007 Reactive Oxygen Species , p53
PK11007 is an anti-p53 drug.
T4325 COTI-2 COTI 2,COTI2 Apoptosis , p53
COTI-2, an orally available thiosemicarbazone, is an activator of mutant forms of the p53 protein with potential antineoplastic activity.
T24730 Roslin 2 bromide Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2 FAK , p53
Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5. Roslin 2 bromide exhibits anticancer effects.
T21773 SP-141 SP 141 Mdm2
SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
T1818 Tenovin-6 Tenovin 6 Dehydrogenase , Sirtuin , Autophagy
Tenovin-6 is a p53 transcriptional activity agonist.
T1919 Tenovin-1 Tenovin 1 Mdm2 , Dehydrogenase , Sirtuin , p53 , Autophagy
Tenovin-1 inhibits protein-deacetylating activities of SirT1 and SirT2 and protects against MDM2-mediated p53 degradation, which involves ubiquitination.
T8480 Tenovin-6 Hydrochloride Dehydrogenase , Sirtuin , HDAC , p53 , Autophagy
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .
T4414 Eprenetapopt APR-246,PRIMA-1Met Apoptosis , Others , Ferroptosis , p53 , Autophagy
Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of c...
T6210 Pifithrin-μ PFTμ,NSC 303580,2-Phenylethynesulfonamide HSP , p53 , Autophagy
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
T1798 RITA NSC 652287,RITA (NSC 652287) Mdm2 , DNA Alkylator/Crosslinker , p53 , Autophagy
RITA (NSC-652287)(NSC-652287) induced cross-links of both DNA-DNA and DNA-protein with no detectable DNA single-strand breaks. RITA, like nutlin-3, can disrupt the p53/Mdm2 interaction.
T8657 KYP-2047 Others
KYP-2047 is a very potent, selective Prolyl oligopeptidase (POP) inhibitor.
T21648 CP-31398 dihydrochloride CP 31398 dihydrochloride p53
CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
T12472 Pifithrin-α, p-Nitro, Cyclic PFN-α p53
Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
T3289 Amifostine Ethyol,WR2721,Gammaphos Others , HIF/HIF Prolyl-Hydroxylase
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T4459 PK11000 DNA Alkylator/Crosslinker
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T3517 RO8994 Mdm2 , E1/E2/E3 Enzyme , p53
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays).
T2158 Nutlin-3 Nutlin3 E1/E2/E3 Enzyme
Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; induces apoptosis in Y cells.
T16888 SJ-172550 Mdm2 , E1/E2/E3 Enzyme
SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T22980 MIRA-1 p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor DNA/RNA Synthesis , p53
MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.
T3653 MX69 Mdm2 , E1/E2/E3 Enzyme , IAP
MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6149 YH239-EE Apoptosis , E1/E2/E3 Enzyme
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
T6381 Amifostine trihydrate Ethyol trihydrate,WR2721,Amifostine Others , HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
TQ0133 Amifostine thiol dihydrochloride WR 1065 p53
Amifostine thiol dihydrochloride (WR 1065) can activate p53 through a JNK-dependent signaling pathway. It also protects normal tissues from the toxic effects of certain cancer drugs.
T11980 MD-224 Mdm2 , E1/E2/E3 Enzyme , PROTACs
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
T6023 Nutlin-3a (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3 Apoptosis , E1/E2/E3 Enzyme , Autophagy
Nutlin-3a ((−)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
T6954 PRIMA-1 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1 Apoptosis , Others , Ferroptosis , Autophagy
PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.
T1493 BH3I-1 BHI1 BCL , E1/E2/E3 Enzyme
BH3I-1 (BHI1) is a Bcl-2 antagonist.
T5555 Siremadlin NVP-HDM 201 E1/E2/E3 Enzyme
Siremadlin (NVP-HDM 201) is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
T6254 Idasanutlin RG7388,Ro 5503781 Mdm2 , E1/E2/E3 Enzyme
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
T24440 MDM2-p53-IN-1b MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
MDM2-p53-IN-1b is the MDM2-p53 interaction inhibitor.
T2243 Serdemetan JNJ-26854165 Apoptosis , Mdm2 , E1/E2/E3 Enzyme , p53
Serdemetan (JNJ-26854165) is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
T6965 RG7112 RG-7112,RG 7112,RO5045337 Mdm2 , E1/E2/E3 Enzyme
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
T7057 Methylstat Histone Demethylase , Others
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...
TQ0231 NVP-CGM097 CGM097 Mdm2 , E1/E2/E3 Enzyme
NVP-CGM097 (CGM097) is an effective and specific MDM2 inhibitor (IC50: 1.7 nM for hMDM2).
TQ0127 Navtemadlin AMG232,CS-1300 Mdm2 , E1/E2/E3 Enzyme
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
T3184 Kevetrin hydrochloride Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride Mdm2 , p53
Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) is a small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity.
T6614 Nutlin-3b (+)-Nutlin-3 Mdm2 , E1/E2/E3 Enzyme
Nutlin-3b ((+)-Nutlin-3) is a p53/MDM2 antagonist or inhibitor (IC50: 13.6 μM), 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.
T6585 SAR405838 MI773,MI 773,MI-77301,MI-773 Mdm2 , E1/E2/E3 Enzyme
MI-773 (SAR405838 (MI 773)) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
T1101 Minocycline hydrochloride Minocycline HCl HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...

Compounds

Inauhzin
T1887
Synonym: INZ
Target: Sirtuin
PhiKan 083
T16523L
Synonym:
Target: Mdm2
NSC 66811
T21578
Synonym:
Target: Mdm2
Tenovin-3
T1873
Synonym: Tenovin3
Target: Sirtuin
MS7972
T8774
Synonym:
Target: Epigenetic Reader Domain
ZMC1
T2464
Synonym:
Target: p53
NSC59984
T6910
Synonym:
Target: p53
cjoc42
T27029
Synonym: cjoc 42,cjoc-42
Target:
XI-006
T6610
Synonym: NSC 207895
Target: Mdm2, p53
NSC 146109 hydrochloride
T12257
Synonym:
Target: Apoptosis, Others
UC2288
T9698
Synonym:
Target: Mdm2, p53
PK11007
T7703
Synonym:
Target: Reactive Oxygen Species, p53
COTI-2
T4325
Synonym: COTI 2,COTI2
Target: Apoptosis, p53
Roslin 2 bromide
T24730
Synonym: Roslin-2,Benzylhexamethylenetetramine bromide,Roslin2
Target: FAK, p53
SP-141
T21773
Synonym: SP 141
Target: Mdm2
Tenovin-6
T1818
Synonym: Tenovin 6
Target: Dehydrogenase, Sirtuin, Autophagy
Tenovin-1
T1919
Synonym: Tenovin 1
Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy
Tenovin-6 Hydrochloride
T8480
Synonym:
Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy
Eprenetapopt
T4414
Synonym: APR-246,PRIMA-1Met
Target: Apoptosis, Others, Ferroptosis, p53, Autophagy
Pifithrin-μ
T6210
Synonym: PFTμ,NSC 303580,2-Phenylethynesulfonamide
Target: HSP, p53, Autophagy
RITA
T1798
Synonym: NSC 652287,RITA (NSC 652287)
Target: Mdm2, DNA Alkylator/Crosslinker, p53, Autophagy
KYP-2047
T8657
Synonym:
Target: Others
CP-31398 dihydrochloride
T21648
Synonym: CP 31398 dihydrochloride
Target: p53
Pifithrin-α, p-Nitro, Cyclic
T12472
Synonym: PFN-α
Target: p53
Amifostine
T3289
Synonym: Ethyol,WR2721,Gammaphos
Target: Others, HIF/HIF Prolyl-Hydroxylase
PK11000
T4459
Synonym:
Target: DNA Alkylator/Crosslinker
RO8994
T3517
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, p53
Nutlin-3
T2158
Synonym: Nutlin3
Target: E1/E2/E3 Enzyme
SJ-172550
T16888
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme
MIRA-1
T22980
Synonym: p53 Activator VIII,1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione,(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate,NSC 19630,WRN Helicase Inhibitor
Target: DNA/RNA Synthesis, p53
MX69
T3653
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, IAP
YH239-EE
T6149
Synonym:
Target: Apoptosis, E1/E2/E3 Enzyme
Amifostine trihydrate
T6381
Synonym: Ethyol trihydrate,WR2721,Amifostine
Target: Others, HIF/HIF Prolyl-Hydroxylase
Amifostine thiol dihydrochloride
TQ0133
Synonym: WR 1065
Target: p53
MD-224
T11980
Synonym:
Target: Mdm2, E1/E2/E3 Enzyme, PROTACs
Nutlin-3a
T6023
Synonym: (-)-Nutlin-3,Nutlin-3a chiral,(−)-Nutlin-3
Target: Apoptosis, E1/E2/E3 Enzyme, Autophagy
PRIMA-1
T6954
Synonym: 2,2-Bis(hydroxymethyl)-3-quinuclidinone,NSC-281668,PRIMA 1
Target: Apoptosis, Others, Ferroptosis, Autophagy
BH3I-1
T1493
Synonym: BHI1
Target: BCL, E1/E2/E3 Enzyme
Siremadlin
T5555
Synonym: NVP-HDM 201
Target: E1/E2/E3 Enzyme
Idasanutlin
T6254
Synonym: RG7388,Ro 5503781
Target: Mdm2, E1/E2/E3 Enzyme
MDM2-p53-IN-1b
T24440
Synonym: MDM2-p53 inhibitor 1b,MDM2 p53 IN 1b
Target:
Serdemetan
T2243
Synonym: JNJ-26854165
Target: Apoptosis, Mdm2, E1/E2/E3 Enzyme, p53
RG7112
T6965
Synonym: RG-7112,RG 7112,RO5045337
Target: Mdm2, E1/E2/E3 Enzyme
Methylstat
T7057
Synonym:
Target: Histone Demethylase, Others
NVP-CGM097
TQ0231
Synonym: CGM097
Target: Mdm2, E1/E2/E3 Enzyme
Navtemadlin
TQ0127
Synonym: AMG232,CS-1300
Target: Mdm2, E1/E2/E3 Enzyme
Kevetrin hydrochloride
T3184
Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride
Target: Mdm2, p53
Nutlin-3b
T6614
Synonym: (+)-Nutlin-3
Target: Mdm2, E1/E2/E3 Enzyme
SAR405838
T6585
Synonym: MI773,MI 773,MI-77301,MI-773
Target: Mdm2, E1/E2/E3 Enzyme
Minocycline hydrochloride
T1101
Synonym: Minocycline HCl
Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
1 2
Cat No. Product Name Synonyms Targets
T4036 Solasodine Solancarpidine,Purapuridine,Solasodin Apoptosis , Others , E1/E2/E3 Enzyme , Antifungal
Solasodine (Purapuridine)(Purapuridine) is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family. Solasodine showed selective cytotoxicity against cervical cancer cell line (HeLa) and huma...
T3798 Ziyuglycoside I Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H Apoptosis , Others
Ziyuglycoside I (Gouguside 7) has anti-inflammatory activity, could be used as an active ingredient for cosmetics.

Natural Products

Solasodine
T4036
Synonym: Solancarpidine,Purapuridine,Solasodin
Target: Apoptosis, Others, E1/E2/E3 Enzyme, Antifungal
Ziyuglycoside I
T3798
Synonym: Gouguside 7,Ziyu-glycoside I,3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester,Zigu-glucoside I,Kudinoside H
Target: Apoptosis, Others

Recombinant Proteins

Species：
Human (245)
Mouse (44)
Cynomolgus (1)
Human (1)
Rat (1)
Expression System：
HEK293 (172)
E. coli (64)
Baculovirus-Insect Cells (28)
Human Cells (27)
Yeast (1)
Tag：
His (104)
hFc (36)
Tag Free (25)
C-6His (20)
C-His-Avi (13)
His,GST (12)
GST (8)
None (8)
C-His (7)
His,AVI (7)
Cat No. Product Name Species Expression System
TMPY-04116 KRAS Protein,Human,Recombinant(G12C & Q61H, His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-02011 CD96 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-00871 LAYN Protein, Human, Recombinant (hFc) Human HEK293
Layilin recently characterized as a 55 kDa transmembrane protein with homology to C-type lectins, is present in numerous cell lines and tissue extracts. As one of the adaptor proteins, talin mediates the interactions bet...
TMPY-00849 ST2/IL-1 RL1 Protein, Human, Recombinant (hFc) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00341 FGFR3 Protein, Human, Recombinant (alpha IIIb, His) Human HEK293
FGFR3, also known as CD333, is a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ ...
TMPY-02792 GDNF Protein, Human, Recombinant (HEK293) Human HEK293
Glial cell line-derived neurotrophic factor(GDNF) is an important member of the GDNF family of ligands(GFL). The GDNF family of ligands is comprised by four neurotrophic factors: glial cell line-derived neurotrophic fact...
TMPY-05288 PLGF/PGF Protein, Human, Recombinant (aa 19-149) Human E. coli
PLGF/PGF Protein, Human, Recombinant (aa 19-149) is expressed in E. coli.
TMPY-00850 ST2/IL-1 RL1 Protein, Human, Recombinant Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPY-00891 Neuropilin-1 Protein, Human, Recombinant (V179A, hFc) Human HEK293
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-00748 Nectin-2 Protein, Human, Recombinant Human HEK293
Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-00005 FGF-8a Protein, Human, Recombinant Human E. coli
In mammalian embryos, transient Fgf8 expression defines the developing isthmic region, lying between the midbrain and the first rhombomere, but there has been uncertainty about the existence of a distinct isthmic segment...
TMPY-02358 CD98 Protein, Mouse, Recombinant (His) Mouse HEK293
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A tr...
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His) Human HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-04051 C-Kit Protein, Human, Recombinant (hFc) Human HEK293
C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-00392 PAM Protein, Human, Recombinant (His) Human HEK293
Peptidylglycine alpha-amidating monooxygenase (PAM) is highly expressed in neurons and endocrine cells, where it catalyzes one of the final steps in the biosynthesis of bioactive peptides. PAM is also expressed in unicel...
TMPY-02432 VEGF164 Protein, Rat, Recombinant Rat Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-04644 PDGFB Protein, Human, Recombinant (His) Human Yeast
Platelet-derived growth factor-B (PDGFB) is necessary for normal cardiovascular development. The administration of PDGFB alone normalized tumor vasculature by increasing periendothelial coverage and vascular functionalit...
TMPY-02231 TrkB Protein, Mouse, Recombinant (His) Mouse HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-01717 VEGF164 Protein, Mouse, Recombinant Mouse Baculovirus-Insect Cells
Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) and VEGF-A, is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the platelet-...
TMPY-01888 KRAS Protein,Human, Recombinant (Q61H, His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-03425 Tau Protein, Human, Recombinant (His) Human E. coli
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-05414 NKG2D/CD314 Protein, Mouse, Recombinant (hFc) Mouse Baculovirus-Insect Cells
KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular protei...
TMPY-00747 Nectin-2 Protein, Human, Recombinant (His) Human HEK293
Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein a...
TMPY-02500 YKL-40/CHI3L1 Protein, Mouse, Recombinant (His) Mouse HEK293
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC c...
TMPY-01442 DMBT1 Protein, Human, Recombinant (His) Human HEK293
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d...
TMPY-01871 IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His) Human HEK293
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA (CD125) is an interleukin 5 specific subunit of a heterodimeric cytokine recept...
TMPY-06056 KRAS Protein, Human, Recombinant (G12D, His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-01613 Periostin/OSF-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01935 C-Kit Protein, Human, Recombinant (His) Human HEK293
C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the pr...
TMPY-00751 TrkB Protein, Human, Recombinant (His) Human HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02367 Neuropilin-1 Protein, Human, Recombinant (isoform b, His) Human HEK293
Neuropilin is a type I transmembrane protein and the molecular mass is 120 kDa. Two homologs, Neuropilin-1 and Neuropilin-2, are identified. The primary structure of Neuropilin-1 and Neuropilin-2 is well conserved and is...
TMPY-02096 TACI Protein, Human, Recombinant (His) Human HEK293
Tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B) also known as Transmembrane activator and CAML interactor (TACI) and CD267 antigen, is a member of the tumor necrosis factor receptor superfamily. TNFRSF...
TMPY-01359 ST2/IL-1 RL1 Protein, Human, Recombinant (His) Human HEK293
IL-1 receptor–like 1 (IL1RL1) is a membrane receptor involved in TH2 inflammatory responses and eosinophilia. It has previously been described that levels of the interleukin-1 like 1 (IL1RL1) protein can be used to diagn...
TMPJ-00850 ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) Mouse Human Cells
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04396 C-ABL/ABL1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cy...
TMPY-04356 GSK3B Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
GSK3B is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It Contains 1 protein kinase domain, and is expressed in the testis, thymus, prostate, and ovary and weakly expressed in the lung, ...
TMPY-02971 CLEC10A Protein, Human, Recombinant (hFc) Human HEK293
CLEC10A, also known as the macrophage galactose-type calcium-type lectins (MGLs; CD301) constitute a unique class of C-type lectins because of their specificity for galactose and its structural homologues. MGLs/CD301 is ...
TMPY-02820 SDF-1 Protein, Human, Recombinant (isoform a) Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-05586 CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
The orthologue of human IGPR-1 is found only in eukaryotes, including primates, the guinea pig, canines, felines, dolphins, bovines, the llama, bats, the common shrew, and horses. Of interest, the IGPR-1 gene is absent i...
TMPY-01199 CD74 Protein, Human, Recombinant (His) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-05427 CD19 Protein, Human, Recombinant (hFc) Human HEK293
The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immu...
TMPY-04113 KRAS Protein,Human,Recombinant(G12D & Q61H, His) Human E. coli
K-Ras belongs to the small GTPase superfamily, Ras family. Like other members of the Ras family, K-Ras is a GTPase and is an early player in many signal transduction pathways. It is usually tethered to cell membranes bec...
TMPY-04844 BTN3A1 Protein, Human, Recombinant (His) Human HEK293
BTN3A1 has the structure of a type I receptor of the Ig superfamily and is part of a family of seven BTN receptors encoded by genes in the MHC. BTN molecules are composed of two Ig domains (IgV, IgC2), a single transmemb...
TMPY-01985 CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 cells.
TMPJ-00335 TGFBR2 Protein, Mouse, Recombinant (His) Mouse Human Cells
Transforming growth factor-β (TGF-β) is an essential regulator in the processes of development, cell proliferation, and extracellular matrix deposition. TGF-β regulates cellular processes by binding to three high-affinit...
TMPY-04829 G-CSF Protein, Human, Recombinant Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-03331 DPEP2 Protein, Human, Recombinant (His) Human HEK293
DPEP2 (MBD-2) belongs to the membrane-bound dipeptidase family. There are three members of this family as membrane-bound dipeptidase-1 (MBD-1),membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3)...
TMPY-01315 EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer), also known as Basigin (BSG), is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence var...
TMPY-02406 CD302 Protein, Mouse, Recombinant (hFc) Mouse HEK293
CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat...
TMPY-03959 CHST11 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondro...
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KRAS Protein,Human,Recombinant(G12C & Q61H, His)
TMPY-04116
Species: Human
Expression System: E. coli
CD96 Protein, Human, Recombinant (His)
TMPY-02011
Species: Human
Expression System: HEK293
LAYN Protein, Human, Recombinant (hFc)
TMPY-00871
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant (hFc)
TMPY-00849
Species: Human
Expression System: HEK293
FGFR3 Protein, Human, Recombinant (alpha IIIb, His)
TMPY-00341
Species: Human
Expression System: HEK293
GDNF Protein, Human, Recombinant (HEK293)
TMPY-02792
Species: Human
Expression System: HEK293
PLGF/PGF Protein, Human, Recombinant (aa 19-149)
TMPY-05288
Species: Human
Expression System: E. coli
ST2/IL-1 RL1 Protein, Human, Recombinant
TMPY-00850
Species: Human
Expression System: HEK293
Neuropilin-1 Protein, Human, Recombinant (V179A, hFc)
TMPY-00891
Species: Human
Expression System: HEK293
Nectin-2 Protein, Human, Recombinant
TMPY-00748
Species: Human
Expression System: HEK293
FGF-8a Protein, Human, Recombinant
TMPY-00005
Species: Human
Expression System: E. coli
CD98 Protein, Mouse, Recombinant (His)
TMPY-02358
Species: Mouse
Expression System: HEK293
Clusterin Protein, Human, Recombinant (CLU34, His)
TMPY-01691
Species: Human
Expression System: HEK293
c-Kit Protein, Human, Recombinant (hFc)
TMPY-04051
Species: Human
Expression System: HEK293
PAM Protein, Human, Recombinant (His)
TMPY-00392
Species: Human
Expression System: HEK293
VEGF164 Protein, Rat, Recombinant
TMPY-02432
Species: Rat
Expression System: Baculovirus-Insect Cells
PDGFB Protein, Human, Recombinant (His)
TMPY-04644
Species: Human
Expression System: Yeast
TrkB Protein, Mouse, Recombinant (His)
TMPY-02231
Species: Mouse
Expression System: HEK293
VEGF164 Protein, Mouse, Recombinant
TMPY-01717
Species: Mouse
Expression System: Baculovirus-Insect Cells
KRAS Protein,Human, Recombinant (Q61H, His)
TMPY-01888
Species: Human
Expression System: E. coli
Tau Protein, Human, Recombinant (His)
TMPY-03425
Species: Human
Expression System: E. coli
NKG2D/CD314 Protein, Mouse, Recombinant (hFc)
TMPY-05414
Species: Mouse
Expression System: Baculovirus-Insect Cells
Nectin-2 Protein, Human, Recombinant (His)
TMPY-00747
Species: Human
Expression System: HEK293
YKL-40/CHI3L1 Protein, Mouse, Recombinant (His)
TMPY-02500
Species: Mouse
Expression System: HEK293
DMBT1 Protein, Human, Recombinant (His)
TMPY-01442
Species: Human
Expression System: HEK293
IL-5R alpha/CD125 Protein, Human, Recombinant(aa 1-335, His)
TMPY-01871
Species: Human
Expression System: HEK293
KRAS Protein, Human, Recombinant (G12D, His)
TMPY-06056
Species: Human
Expression System: E. coli
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
TMPY-01613
Species: Mouse
Expression System: HEK293
c-Kit Protein, Human, Recombinant (His)
TMPY-01935
Species: Human
Expression System: HEK293
TrkB Protein, Human, Recombinant (His)
TMPY-00751
Species: Human
Expression System: HEK293
Neuropilin-1 Protein, Human, Recombinant (isoform b, His)
TMPY-02367
Species: Human
Expression System: HEK293
TACI Protein, Human, Recombinant (His)
TMPY-02096
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Human, Recombinant (His)
TMPY-01359
Species: Human
Expression System: HEK293
ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
TMPJ-00850
Species: Mouse
Expression System: Human Cells
C-ABL/ABL1 Protein, Human, Recombinant (GST)
TMPY-04396
Species: Human
Expression System: Baculovirus-Insect Cells
GSK3B Protein, Human, Recombinant (His)
TMPY-04356
Species: Human
Expression System: Baculovirus-Insect Cells
CLEC10A Protein, Human, Recombinant (hFc)
TMPY-02971
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant (isoform a)
TMPY-02820
Species: Human
Expression System: E. coli
CD28H/TMIGD2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-05586
Species: Human
Expression System: HEK293
CD74 Protein, Human, Recombinant (His)
TMPY-01199
Species: Human
Expression System: HEK293
CD19 Protein, Human, Recombinant (hFc)
TMPY-05427
Species: Human
Expression System: HEK293
KRAS Protein,Human,Recombinant(G12D & Q61H, His)
TMPY-04113
Species: Human
Expression System: E. coli
BTN3A1 Protein, Human, Recombinant (His)
TMPY-04844
Species: Human
Expression System: HEK293
CD32B/Fcgr2b Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-01985
Species: Human
Expression System: HEK293
TGFBR2 Protein, Mouse, Recombinant (His)
TMPJ-00335
Species: Mouse
Expression System: Human Cells
G-CSF Protein, Human, Recombinant
TMPY-04829
Species: Human
Expression System: HEK293
DPEP2 Protein, Human, Recombinant (His)
TMPY-03331
Species: Human
Expression System: HEK293
EMMPRIN/CD147 Protein, Mouse, Recombinant (His & hFc)
TMPY-01315
Species: Mouse
Expression System: HEK293
CD302 Protein, Mouse, Recombinant (hFc)
TMPY-02406
Species: Mouse
Expression System: HEK293
CHST11 Protein, Human, Recombinant (His)
TMPY-03959
Species: Human
Expression System: Baculovirus-Insect Cells
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