Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenovin-6 is a p53 transcriptional activity agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 36.00 | |
2 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 243.00 | |
100 mg | In stock | $ 413.00 | |
500 mg | In stock | $ 979.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | Tenovin-6 is a p53 transcriptional activity agonist. |
Targets&IC50 | SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM |
In vivo | Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1]. |
Kinase Assay | Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr. |
Cell Research | The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve. |
Synonyms | Tenovin 6 |
Molecular Weight | 454.63 |
Formula | C25H34N4O2S |
CAS No. | 1011557-82-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 91 mg/mL (200.2 mM)
H2O: 90 mg/mL (198 mM)
You can also refer to dose conversion for different animals. More
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Tenovin-6 1011557-82-6 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Dehydrogenase Sirtuin Dihydroorotate Dehydrogenase Inhibitor MDM-2/p53 MDM2 Tenovin6 acetylation degradation DHODH Tenovin 6 inhibit protein-deacetylating inhibitor