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Tenovin-6

Catalog No. T1818   CAS 1011557-82-6
Synonyms: Tenovin 6

Tenovin-6 is a p53 transcriptional activity agonist.

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Tenovin-6 Chemical Structure
Tenovin-6, CAS 1011557-82-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 51.00
5 mg In stock $ 70.00
10 mg In stock $ 89.00
25 mg In stock $ 159.00
50 mg In stock $ 243.00
100 mg In stock $ 413.00
500 mg In stock $ 979.00
1 mL * 10 mM (in DMSO) In stock $ 72.00
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Purity: 100%
Purity: 97.71%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Tenovin-6 is a p53 transcriptional activity agonist.
Targets&IC50 SIRT1:21 μM, SIRT3:67 μM, SIRT2:10 μM
In vivo Tenovins are active on mammalian cells at one-digit micromolar concentrations and decrease tumor growth in vivo as single agents. Tenovin-6 (50 mg/kg, i.p.) inhibits the growth of tumor in mice[1].
Kinase Assay Assays are carried out using purified components in the Fluor de Lys Fluorescent Assay Systems. Relevant FdL substrates are used at 7 μM and NAD+ at 1 mM. Tenovins are solubilized in DMSO with the final DSMO concentration in the reaction being less than 0.25%. For SirT1 and HDAC8, one unit of enzyme is used per reaction, and for SirT2 and SirT3, five units is used per reaction. Reactions are carried out at 37°C for 1 hr.
Cell Research The MTS assay is used to evaluate cell viability. UM cells are seeded into each well of 96-well plates (5,000 cells/well) and treated the next day with control or Tenovin-6 in an increasing concentrations from 0 to 20?μM for 68?h, and then MTS is added at 20?μL/well to be read at a wave length of 490?nm, the IC50 is determined by curve fitting of the sigmoidal dose-response curve.
Synonyms Tenovin 6
Molecular Weight 454.63
Formula C25H34N4O2S
CAS No. 1011557-82-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: <1 mg/mL

DMSO: 91 mg/mL (200.2 mM)

H2O: 90 mg/mL (198 mM)

TargetMolReferences and Literature

1. Lain S, et al. Cancer Cell, 2008, 13(5), 454-463.

Related compound libraries

This product is contained In the following compound libraries:
DNA Damage & Repair Compound Library Metabolism Compound Library Anti-Colorectal Cancer Compound Library Chromatin Modification Compound Library Glutamine Metabolism Compound Library Mitochondria-Targeted Compound Library Anti-Cancer Compound Library Stem Cell Differentiation Compound Library Reprogramming Compound Library PPI Inhibitor Library

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PROTAC Sirt2 Degrader-1 Nicotinamide Riboside Triflate SIRT5 inhibitor 6 SIRT5 inhibitor 7 SIRT5 inhibitor 8 SIRT5 inhibitor 9 Sirt1/2-IN-2 Sirt1/2-IN-3

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Keywords

Tenovin-6 1011557-82-6 Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair Metabolism Sirtuin Dehydrogenase Dihydroorotate Dehydrogenase Inhibitor MDM-2/p53 MDM2 Tenovin6 acetylation degradation DHODH Tenovin 6 inhibit protein-deacetylating inhibitor

 

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