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PK11007

Name: PK11007
Brand: TargetMol
SKU: T7703
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7703Cas No. 874146-69-7

PK11007 is an anti-p53 drug.

PK11007

🥰Excellent

Purity: 97.55%

Catalog No. T7703Cas No. 874146-69-7

PK11007 is an anti-p53 drug.

Pack Size	Price	Availability
1 mg	$32	In Stock
5 mg	$73	In Stock
10 mg	$106	In Stock
25 mg	$198	In Stock
50 mg	$297	In Stock
100 mg	$438	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock

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Batch Information

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Purity:97.55%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PK11007 is an anti-p53 drug.
In vivo	Targeting mutant p53 with PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease[1].

Chemical Properties

Molecular Weight	427.86
Formula	C₁₅H₁₁ClFN₅O₃S₂
Cas No.	874146-69-7
Smiles	Cc1nnc(NC(=O)c2nc(ncc2Cl)S(=O)(=O)Cc2ccc(F)cc2)s1
Relative Density.	1.610 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (233.72 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3372 mL	11.6861 mL	23.3721 mL	116.8607 mL
5 mM	0.4674 mL	2.3372 mL	4.6744 mL	23.3721 mL
10 mM	0.2337 mL	1.1686 mL	2.3372 mL	11.6861 mL
20 mM	0.1169 mL	0.5843 mL	1.1686 mL	5.8430 mL
50 mM	0.0467 mL	0.2337 mL	0.4674 mL	2.3372 mL
100 mM	0.0234 mL	0.1169 mL	0.2337 mL	1.1686 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc