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Catalog No. T7703   CAS 874146-69-7

PK11007 is an anti-p53 drug.

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PK11007 Chemical Structure
PK11007, CAS 874146-69-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 32.00
5 mg In stock $ 73.00
10 mg In stock $ 106.00
25 mg In stock $ 198.00
50 mg In stock $ 297.00
100 mg In stock $ 438.00
1 mL * 10 mM (in DMSO) In stock $ 80.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PK11007 is an anti-p53 drug.
In vivo Targeting mutant p53 with PK11007 is a potential approach for treating p53-mutated breast cancer, including the subgroup with TN disease[1].
Molecular Weight 427.86
Formula C15H11ClFN5O3S2
CAS No. 874146-69-7


Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.28 mg/mL (10 mM), Sonication is recommended.

TargetMolReferences and Literature

1. Synnott N C , Bauer M R , Madden S , et al. Mutant p53 as A Therapeutic Target for the Treatment of Triple-Negative Breast Cancer: Preclinical Investigation with the Anti-p53 Drug, PK11007[J]. Cancer Letters, 2017:S0304383517306225. 2. Duffy M J , Synnott N C , Crown J . Mutant p53 in breast cancer: potential as a therapeutic target and biomarker[J]. Breast Cancer Research and Treatment, 2018.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Lung Cancer Compound Library Anti-Cancer Compound Library Ferroptosis Compound Library Anti-Aging Compound Library Stem Cell Differentiation Compound Library Bioactive Compound Library Metabolism Compound Library Mitochondria-Targeted Compound Library Oxidation-Reduction Compound Library

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


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PK11007 874146-69-7 Apoptosis Immunology/Inflammation Metabolism NF-Κb p53 Reactive Oxygen Species inhibit MDM-2/p53 Inhibitor PK 11007 PK-11007 inhibitor