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SP-141

Catalog No. T21773   CAS 1253491-42-7
Synonyms: SP 141

SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SP-141 Chemical Structure
SP-141, CAS 1253491-42-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
5 mg In stock $ 85.00
10 mg In stock $ 130.00
25 mg In stock $ 288.00
50 mg In stock $ 481.00
100 mg In stock $ 688.00
1 mL * 10 mM (in DMSO) In stock $ 98.00
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Purity: 99.21%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SP 141 is a MDM2 inhibitor.SP-141 promotes MDM2 auto-ubiquitination and degradation, with anticancer activity.
In vitro SP141, which bound directly to MDM2, promoting its auto-ubiquitination and degradation by the proteasome.?The compound reduced levels of MDM2 in pancreatic cancer cell lines, as well as their proliferation, with 50% inhibitory concentrations <0.5 μM (0.38-0.50 μM).?Increasing concentrations of SP141 induced increasing levels of apoptosis and G2-M-phase arrest of pancreatic cancer cell lines, whether or not they expressed functional P53[1].
In vivo Injection of nude mice with SP141 (40 mg/kg/d) inhibited growth of xenograft tumors (by 75% compared with control mice), and led to regression of orthotopic tumors[1].
Synonyms SP 141
Molecular Weight 324.38
Formula C22H16N2O
CAS No. 1253491-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.4 mg/mL (13.56 mM)

TargetMolReferences and Literature

1. Wei Wang, et al. The Pyrido[b]indole MDM2 Inhibitor SP-141 Exerts Potent Therapeutic Effects in Breast Cancer Models. Nat Commun. 2014 Oct 1;5:5086. 2. Wei Wang , et al. Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice. Gastroenterology. 2014 Oct;147(4):893-902.e2.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Lung Cancer Compound Library Anti-Aging Compound Library Transcription Factor-Targeted Compound Library NO PAINS Compound Library Ubiquitination Compound Library Bioactive Compound Library Pyroptosis Compound Library PPI Inhibitor Library Anti-Colorectal Cancer Compound Library

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Keywords

SP-141 1253491-42-7 Apoptosis Mdm2 pancreatic inhibit SP 141 Inhibitor cancer MDM-2/p53 breast degradation SP141 auto-ubiquitination inhibitor

 

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