Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 52.00 | |
10 mg | In stock | $ 85.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 288.00 | |
100 mg | In stock | $ 490.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 57.00 |
Description | NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM). |
Targets&IC50 | p53 (R175):8 nM |
Kinase Assay | MTS: 5,000 cells of TOV112D cells (5,000 cells/well, in 100 ml culture) are cultured in 96-well plate to reach the 50%–60% confluence on the second day when treated with serial dilutions of the compounds. The growth is measured by MTS reagent and Victor Plate reader instrument after incubation for 3 days. |
Cell Research | Viability assays are done. The cells (5×104 cells/well, in 1 ml culture) are cultured in a 12-well plate to reach the 50%–60% confluence on the second day when treated with serial dilutions of the compound. The growth is measured by Guava ViaCount reagent and Guava PCA instrument after incubation for 3 days.(Only for Reference) |
Molecular Weight | 234.32 |
Formula | C11H14N4S |
CAS No. | 71555-25-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2.3 mg/mL (10 mM)), Heating is recommended.
DMSO: 23.4 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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ZMC1 71555-25-4 Apoptosis p53 NSC 319726 MDM-2/p53 inhibit ZMC 1 ZMC-1 NSC-319726 NSC319726 Inhibitor inhibitor