Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 109.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 597.00 | |
500 mg | In stock | $ 1,260.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | NSC59984, a p53 pathway activator, induces mutant p53 protein degradation and p73 activation. |
In vitro | NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells. [1] |
In vivo | In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. [1] |
Cell Research | Cells are seeded at 5,000 cells per well on 96-well plates. Cells are mixed with an equal volume of CellTiter-Glo reagents, following the manufacturer's protocol, and bioluminescence imaging is measured using the IVIS imager.(Only for Reference) |
Molecular Weight | 265.27 |
Formula | C12H15N3O4 |
CAS No. | 803647-40-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 49 mg/mL (184.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 49 mg/mL (184.7 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NSC59984 803647-40-7 Apoptosis p53 inhibit Inhibitor NSC-59984 MDM-2/p53 NSC 59984 inhibitor