Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 60.00 | |
10 mg | In stock | $ 96.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 100.00 |
Description | YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. |
In vitro | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1] |
Cell Research | Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference) |
Molecular Weight | 504.41 |
Formula | C25H27Cl2N3O4 |
CAS No. | 1364488-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 15 mg/mL (29.7 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 93 mg/mL (184.4 mM)
You can also refer to dose conversion for different animals. More
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YH239-EE 1364488-67-4 Apoptosis Ubiquitination E1/E2/E3 Enzyme E2 conjugating enzyme Ubiquitin activating enzyme YH239 EE Ubiquitin conjugating enzyme E1 activating enzyme E3 ligating enzyme inhibit Inhibitor YH-239-EE YH239EE MDM-2/p53 Ubiquitin ligase inhibitor