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Apoptosis Mdm2 SJ-172550

SJ-172550

Catalog No. T16888   CAS 431979-47-4

SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).

SJ-172550, CAS 431979-47-4
Pack Size Availability Price/USD Quantity
2 mg In stock 58.00
5 mg In stock 82.00
10 mg In stock 122.00
25 mg In stock 281.00
50 mg In stock 515.00
100 mg In stock 777.00
1 mL * 10 mM (in DMSO) In stock 92.00
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Purity 99.87%
Biological Description
Chemical Properties
Storage & Solubility Information
Description SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
Targets&IC50 MDMX
In vitro SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates [1][2].
Molecular Weight 428.87
Formula C22H21ClN2O5
CAS No. 431979-47-4

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 33.33 mg/mL (77.72 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Reed D, et al. Identification and characterization of the first small molecule inhibitor of MDMX. J Biol Chem. 2010 Apr 2;285(14):10786-96. 2. Bista M, et al. On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53. PLoS One. 2012;7(6):e37518.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Apoptosis Compound Library

Related Products

Related compounds with same targets
NVP-CGM097 MA242 SJ-172550 RO-5963 Isosilybin B Triglycidyl isocyanurate AM-8735 IVHD-valtrate

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