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MIRA-1

Catalog No. T22980 CAS 72835-26-8

Synonyms: p53 Activator VIII, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, NSC 19630, WRN Helicase Inhibitor

MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

MIRA-1, CAS 72835-26-8

Pack Size	Availability	Price/USD
2 mg	In stock	$ 34.00
5 mg	In stock	$ 55.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 197.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 449.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.38%

Biological Description

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Description	MIRA-1 (WRN Helicase Inhibitor) is a restorer of wild-type p53 conformation/cellular function and selectively inhibits Werner syndrome WRN helicase activity with an IC50 of 20 µM.
Targets&IC50	p53:10μM, WRN helicase:20 µM
In vitro	MIRA-1 induces p53 transcriptional transactivation of p21, MDM2, and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro with an IC50 of 10μM[1].

Synonyms	p53 Activator VIII, 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione, (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate, NSC 19630, WRN Helicase Inhibitor
Molecular Weight	183.16
Formula	C8H9NO4
CAS No.	72835-26-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL(109.19 mM)

Ethanol: 20 mg/mL(109.19 mM)

References and Literature

1. Moles R, Bai XT, Chaib-Mezrag H, Nicot C. WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells. J Hematol Oncol. 2016 Nov 9;9(1):121. 2. Bou-Hanna C, Jarry A, Lode L, Schmitz I, Schulze-Osthoff K, Kury S, Bezieau S, Mosnier JF, Laboisse CL. Acute cytotoxicity of MIRA-1/NSC19630, a mutant p53-reactivating small molecule, against human normal and cancer cells via a caspase-9-dependent apoptosis. Cancer Lett. 2015 Apr 10;359(2):211-7.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Cancer Metabolism Compound Library Anti-Aging Compound Library Metabolism Compound Library Transcription Factor-Targeted Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Anti-Pancreatic Cancer Compound Library Cell Cycle Compound Library Anti-Colorectal Cancer Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MIRA-1 72835-26-8 Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair p53 DNA/RNA Synthesis inhibit MDM-2/p53 p53 Activator VIII MIRA 1 1-[(1-Oxopropoxy)methyl]-1H-pyrrole-2,5-dione NSC19630 Inhibitor H1299 SKOV (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl propionate NSC 19630 WRN Helicase Inhibitor MIRA1 NSC-19630 Anticancer Saos-2 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.