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CP-31398 dihydrochloride

Catalog No. T21648 CAS 1217195-61-3

Synonyms: CP 31398 dihydrochloride

CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CP-31398 dihydrochloride Chemical Structure

CP-31398 dihydrochloride, CAS 1217195-61-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 31.00
2 mg	In stock	$ 44.00
5 mg	In stock	$ 70.00
10 mg	In stock	$ 116.00
25 mg	In stock	$ 226.00
50 mg	In stock	$ 363.00
100 mg	In stock	$ 593.00
200 mg	In stock	$ 843.00
500 mg	In stock	$ 1,250.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 99.53%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CP-31398 dihydrochloride is a p53 stabilizer which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
In vitro	CP-31398 (15 μg/mL, 20 hours) could induce apoptosis and cell cycle arrest in SW480 cells[1]. CP-31398 (36.75 μM, 16 h) induces p21 in p53-mutant cells[2].

Synonyms	CP 31398 dihydrochloride
Molecular Weight	435.4
Formula	C22H28Cl2N4O
CAS No.	1217195-61-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6 mg/ml (13.78 mM)

References and Literature

1. Rishu Takimoto, et al. The Mutant p53-Conformation Modifying Drug, CP-31398, Can Induce Apoptosis of Human Cancer Cells and Can Stabilize Wild-Type p53 Protein. Cancer Biol Ther. Jan-Feb 2002;1(1):47-55. 2. B A Foster, et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library Transcription Factor-Targeted Compound Library Bioactive Compound Library Anti-Aging Compound Library Metabolism Compound Library PPI Inhibitor Library Ferroptosis Compound Library NO PAINS Compound Library

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Keywords

CP-31398 dihydrochloride 1217195-61-3 Apoptosis p53 CP-31398 inhibit CP31398 Dihydrochloride CP 31398 dihydrochloride CP31398 CP 31398 Dihydrochloride CP 31398 CP31398 dihydrochloride MDM-2/p53 Inhibitor CP-31398 Dihydrochloride inhibitor

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