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Serdemetan

Catalog No. T2243 CAS 881202-45-5

Synonyms: N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺, JNJ-26854165

Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Serdemetan, CAS 881202-45-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
Targets&IC50	REH cells:0.44 μM, OCI-AML-3:0.24 μM, MOLM-13:0.33 μM, NALM-6:0.32 μM
Cell Research	Cell lines are maintained in RPMI 1640 medium containing 10% heat-inactivated fetal calf serum (FCS). OCI-AML-3, MOLM-13, NB4 and U937 cells are derived from acute myelogenous leukemia (AML) patients, K562 from a chronic myelogenous leukemia (CML) patient in blast crisis, and NALM-6, REH, P12-ICHIK(Only for Reference)

Synonyms	N-[2-(1H-吲哚-3-基)乙基]-N'-(4-吡啶基)-1,4-苯二胺, JNJ-26854165
Molecular Weight	328.419
Formula	C21H20N4
CAS No.	881202-45-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 2 mg/mL (6.08 mM)

H2O: <1 mg/mL

DMSO: 61 mg/mL (185.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kojima K, et al. Mol Cancer Ther. 2010, 9(9), 2545-2557. 2. Yuan Y, et al. J Hematol Oncol. 2011, 4:16. 3. Chargari C, et al. Cancer Lett. 2011, 312(2), 209-218. 4. Smith MA, et al. Pediatr Blood Cancer, 2012, 59(2), 329-332. 5. Liu Z, Chen Y, Gao H, et al. Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells[J]. OncoTargets and Therapy . 2020, 13: 12151-12162.

Citations

1. Liu Z, Chen Y, Gao H, et al. Berberine Inhibits Cell Proliferation by Interfering with Wild-Type and Mutant P53 in Human Glioma Cells. OncoTargets and Therapy. 2020, 13: 12151-12162.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Glutamine Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Serdemetan 881202-45-5 凋亡泛素化 Apoptosis E1/E2/E3 Enzyme Mdm2 p53 JNJ 26854165 E3 ligating enzyme Ubiquitin activating enzyme E1 activating enzyme Ubiquitin ligase Inhibitor E2 conjugating enzyme JNJ26854165 inhibit JNJ-26854165 Ubiquitin conjugating enzyme MDM-2/p53 inhibitor

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