nm-23 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13246	UCT943		Parasite , PI4K
	UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).		Parasite , PI4K
T6012	SAR131675	SAR 131675	VEGFR
	SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.		VEGFR
TQ0012	AZ3451		Protease-activated Receptor
	AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).		Protease-activated Receptor
T3177	Orexin 2 Receptor Agonist	OX2R	OX Receptor
	Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.		OX Receptor
T2630	Poziotinib	HM781-36B,NOV120101	Apoptosis , EGFR , HER
	Poziotinib (NOV120101)(NOV120101; HM781-36B) is an irreversible HER1/2/4 inhibitor (IC50s: 3/5/23 nM).		Apoptosis , EGFR , HER
T16841	SAR-260301		PI3K
	SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).		PI3K
T12231	NITD-349		Others , Antibacterial
	NITD-349 is an inhibitor of MmpL3. It shows highly potent anti-mycobacterial activity with MIC50 of 23 nM against virulent Mycobacterium tuberculosis H37Rv.		Others , Antibacterial
T11696	Ivachtin	Caspase-3 Inhibitor VII	Caspase
	Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases.		Caspase
T1857	TMP269		HDAC
	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.		HDAC
T6039	TAK-285	TAK285,TAK 285	EGFR , MEK , HER , Aurora Kinase
	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.		EGFR , MEK , HER , Aurora Kinase
T14365	AZ PFKFB3 26		Glucokinase
	AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.		Glucokinase
T4385	PF-4840154		TRP/TRPV Channel
	PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.		TRP/TRPV Channel
TQ0010	Brepocitinib	PF-06700841	Tyrosine Kinases , JAK
	Brepocitinib (PF-06700841) is a potent dual JAK1/TYK2 inhibitor (IC50s: 17 nM/23 nM). Brepocitinib also inhibits JAK2/3 (IC50s: 77 nM/6.49 μM).		Tyrosine Kinases , JAK
T17204	UNC0321		Histone Methyltransferase
	UNC0321 is an effective inhibitor of histone methyltransferase G9a with a Ki of 63 pM and with IC50s 9 nM and 6 nM in ECSD and CLOT assays. UNC0321 inhibits GLP with IC50s of 15 nM and 23 nM in ECSD and CLOT assays.		Histone Methyltransferase
TP1858L	Phe-Met-Arg-Phe, amide acetate	Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)	Potassium Channel
	Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.		Potassium Channel
T21593	AAL-993		VEGFR
	AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni...		VEGFR
T22272	Lifirafenib	BGB-283,Beigene-283	EGFR , Raf
	Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respective...		EGFR , Raf
T17182	TX1-85-1		EGFR
	TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a cova...		EGFR
T62512	IHMT-MST1-58		Hippo pathway
	IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to study type 1 or type 2 diabetes.		Hippo pathway
T1791L	Ceritinib dihydrochloride	LDK378 dihydrochloride	IGF-1R , ALK
	Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7...		IGF-1R , ALK
T14367	AZ1495		IRAK , CDK , Haspin Kinase
	AZ1495 is an oral active inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4), with IC50 values of 5 nM and 23 nM for IRAK4 and IRAK1, respectively. Which Shows activity in treatment of mutant MYD88L265P diffu...		IRAK , CDK , Haspin Kinase
T4210	SAR-20347	SAR20347	Tyrosine Kinases , JAK
	SAR-20347 is an inhibitor of TYK2, JAK1/2/3 (IC50: 0.6/23/26/41 nM).		Tyrosine Kinases , JAK
T1809	AGI-6780		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
	AGI-6780 is a potent and selective inhibitor of IDH2 R140Q mutant.		Dehydrogenase , Isocitrate Dehydrogenase (IDH)
T6143	PI-103	PI103,PI 103	Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
	PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).		Apoptosis , DNA-PK , PI3K , mTOR , Autophagy
T6020	Pacritinib	SB1518	FLT , Tyrosine Kinases , JAK
	Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).		FLT , Tyrosine Kinases , JAK
T77500	Casein kinase 1δ-IN-6		Casein Kinase
	Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-inflammatory activity in both in vitro and in vivo assays.C...		Casein Kinase
T12427	Brepocitinib P-Tosylate	PF-06700841 P-Tosylate	JAK
	Brepocitinib P-Tosylate (PF-06700841 P-Tosylate) is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).		JAK
T14363	AZ-23	AZ 23,AZ23	Trk receptor
	AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.		Trk receptor
T3533	Apilimod mesylate	STA 5326 mesylate	IL Receptor , PI3K , Interleukin
	Apilimod mesylate (STA 5326 mesylate) is a potent IL-12/IL-23 inhibitor.		IL Receptor , PI3K , Interleukin
T60050	ANT3310		Antibacterial
	ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.		Antibacterial
T20789	S-23	(S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23	Androgen Receptor
	S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal ve...		Androgen Receptor
T5398	BMS 599626 2HCl (873837-23-1(HCl))	AC480 dihydrochloride	HER
	BMS 599626 2HCl (873837-23-1(HCl)) (AC480 dihydrochloride) is a selective inhibitor of HER1 and HER2 (IC50s: 20 nM and 30 nM), ~8-fold less potent to HER4, >100-fold to Lck, VEGFR2, c-Kit, MET, etc.		HER
T2018	Apilimod	STA 5326	IL Receptor , PI3K , Interleukin
	Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.		IL Receptor , PI3K , Interleukin
T6337	RepSox	ALK5 Inhibitor II,SJN 2511,E-616452	ALK , TGF-beta/Smad
	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.		ALK , TGF-beta/Smad
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T1791	Ceritinib	LDK378	Serine Protease , IGF-1R , ALK
	Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).		Serine Protease , IGF-1R , ALK
T23347	SDZ WAG 994		Adenosine Receptor
	SDZ WAG 994 is an A1 adenosine receptor agonist.		Adenosine Receptor
T2365	Pilaralisib	SAR245408,XL-147	PI3K
	Pilaralisib (XL-147) is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials studying the treatment of Cancer, Lymphoma, Solid...		PI3K
T10215	AAPK-25		Apoptosis , PLK , Aurora Kinase
	AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in prometaphase, followed by a surge in apoptosis. AAPK-25 targets Aurora-A/-B/-C with ...		Apoptosis , PLK , Aurora Kinase
T14687	Deucravacitinib	BMS-986165	Tyrosine Kinases , JAK , IFNAR , Interleukin
	Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively bi...		Tyrosine Kinases , JAK , IFNAR , Interleukin
T21696	SC-57461A		Aminopeptidase
	SC 57461A is a potent and specific leukotriene A4 hydrolase (LTA4H) inhibitor.		Aminopeptidase
T2092	Amitifadine hydrochloride	DOV-21947 hydrochloride,EB-1010 hydrochloride	Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
	Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
T9592	OATD-01		Others
	OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).		Others
T2061	APY0201		PI3K , Interleukin
	APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3, 5)P2.		PI3K , Interleukin
T6643	Ro 31-8220 Mesylate	Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate	PKC
	Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.		PKC
T28368	PF-04859989 HCl	PF 04859989,PF04859989,PF-04859989HCl,PF-04859989	Others
	PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid. PF-04859989 HCl has been implicated in s...		Others
T6797	Telaglenastat	CB 839,CB839,CB-839	transporter , Glutaminase , Autophagy
	Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.		transporter , Glutaminase , Autophagy
T3620	Solcitinib	GLPG-0778,GSK-2586184	JAK
	Solcitinib (GLPG-0778) (GSK2586184, GLPG0778) is a JAK1 inhibitor. Solcitinib may be potentially used for the treatment of psoriasis, ulcerative colitis, and systemic lupus erythematosus.		JAK
T7336	ICA-121431	2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl	Sodium Channel
	ICA-121431 (2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl) is a nanomolar potent small molecule Nav1.7 channel inhibitor with IC50 of 19 nM for rat Nav1.7, with little or no activity against human Nav1.5 or Nav1.7 channels.		Sodium Channel
T4393	MS049 2HCl (1502816-23-0(free base))		Histone Methyltransferase
	MS049 is a potent and selective inhibitor of PRMT4 (IC50 = 34 nM) and PRMT6 (IC50 = 43 nM). It is less active against additional type I PRMTs (IC50s = >130, >220, and 1.6 μM for PRMT1, PRMT3, and PRMT8, respectively) and...		Histone Methyltransferase

Compounds

UCT943

T13246

Synonym:

Target: Parasite, PI4K

Target: Protease-activated Receptor

Orexin 2 Receptor Agonist

Synonym: HM781-36B,NOV120101

Target: Apoptosis, EGFR, HER

Target: Others, Antibacterial

Ivachtin

T11696

Synonym: Caspase-3 Inhibitor VII

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

Target: TRP/TRPV Channel

Brepocitinib

TQ0010

Synonym: PF-06700841

Target: Tyrosine Kinases, JAK

UNC0321

T17204

Synonym:

Target: Histone Methyltransferase

Phe-Met-Arg-Phe, amide acetate

TP1858L

Synonym: Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)

Target: Potassium Channel

Synonym: BGB-283,Beigene-283

Target: Hippo pathway

Ceritinib dihydrochloride

T1791L

Synonym: LDK378 dihydrochloride

Target: IRAK, CDK, Haspin Kinase

SAR-20347

T4210

Synonym: SAR20347

Target: Tyrosine Kinases, JAK

AGI-6780

T1809

Synonym:

Target: Dehydrogenase, Isocitrate Dehydrogenase (IDH)

PI-103

T6143

Synonym: PI103,PI 103

Target: Apoptosis, DNA-PK, PI3K, mTOR, Autophagy

Pacritinib

T6020

Synonym: SB1518

Target: FLT, Tyrosine Kinases, JAK

Casein kinase 1δ-IN-6

T77500

Synonym:

Target: Casein Kinase

Brepocitinib P-Tosylate

T12427

Synonym: PF-06700841 P-Tosylate

Synonym: STA 5326 mesylate

Target: IL Receptor, PI3K, Interleukin

ANT3310

T60050

Synonym:

Target: Antibacterial

S-23

T20789

Synonym: (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide,S23

Target: Androgen Receptor

BMS 599626 2HCl (873837-23-1(HCl))

T5398

Synonym: AC480 dihydrochloride

Target: IL Receptor, PI3K, Interleukin

RepSox

T6337

Synonym: ALK5 Inhibitor II,SJN 2511,E-616452

Target: ALK, TGF-beta/Smad

Sertindole

T5858

Synonym: Lu 23-174

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Autophagy

Ceritinib

T1791

Synonym: LDK378

Target: Serine Protease, IGF-1R, ALK

SDZ WAG 994

T23347

Synonym:

Target: Adenosine Receptor

Pilaralisib

T2365

Synonym: SAR245408,XL-147

Target: Apoptosis, PLK, Aurora Kinase

Deucravacitinib

T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

SC-57461A

T21696

Synonym:

Target: Aminopeptidase

Amitifadine hydrochloride

T2092

Synonym: DOV-21947 hydrochloride,EB-1010 hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Target: PI3K, Interleukin

Ro 31-8220 Mesylate

T6643

Synonym: Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate

Target: PKC

PF-04859989 HCl

T28368

Synonym: PF 04859989,PF04859989,PF-04859989HCl,PF-04859989

Target: Others

Telaglenastat

T6797

Synonym: CB 839,CB839,CB-839

Target: transporter, Glutaminase, Autophagy

Solcitinib

T3620

Synonym: GLPG-0778,GSK-2586184

Target: JAK

ICA-121431

T7336

Synonym: 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl

Target: Sodium Channel

MS049 2HCl (1502816-23-0(free base))

T4393

Synonym:

Target: Histone Methyltransferase

Cat No.	Product Name	Species	Expression System
TMPY-04467	NME1 Protein, Human, Recombinant (His)	Human	E. coli
	NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the inter...
TMPH-03062	Norovirus (strain Human/NoV/United States/Norwalk/1968/GI) VP1 Protein (Flag & Myc)	Norwalk virus	HEK293 Cells
	Capsid protein self assembles to form an icosahedral capsid with a T=3 symmetry, about 38 nm in diameter, and consisting of 180 capsid proteins. A smaller form of capsid with a diameter of 23 nm might be capsid proteins ...

Search Result

Targets

Compounds

Natural Products

Recombinant Proteins

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T37609	(rel)-Asperparaline A
	Aspergillimide is a fungal metabolite originally isolated from A. japonicus.1 It reduces nicotinic acetylcholine receptor (nAChR) peak and slowly-desensitizing amplitudes induced by acetylcholine in silkworm (B. mori) la...