Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 177.00 | |
2 mg | In stock | $ 268.00 | |
5 mg | In stock | $ 455.00 | |
10 mg | In stock | $ 672.00 | |
25 mg | In stock | $ 1,060.00 | |
50 mg | In stock | $ 1,430.00 | |
100 mg | In stock | $ 1,920.00 | |
500 mg | In stock | $ 3,850.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 490.00 |
Description | UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM). |
Targets&IC50 | PvPI4K:23 nM |
In vitro | UCT943 maintains a high degree of selectivity (>200-fold) for parasite PI4K versus human PI4Kβ isoenzyme (IC50 = 5.4 μM) in vitro, and its inhibition is associated with immunosuppressive effects[1]. |
In vivo | In vivo, UCT943 shows good efficacy in the Plasmodium vivax (3-10 mg/kg; orally) and P. falciparum NSG mouse models (0.01-10 mg/kg; orally). UCT943 (10 mg/kg; p.o.) reduces parasitemia by >99.9% in the mouse P. berghei infection model and cures all mice (MSD>30)[1]. |
Molecular Weight | 427.42 |
Formula | C22H20F3N5O |
CAS No. | 1450666-80-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (467.9 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
UCT943 1450666-80-4 Microbiology/Virology PI3K/Akt/mTOR signaling Parasite PI4K UCT 943 UCT-943 inhibitor inhibit