Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
5 mg | In stock | $ 155.00 | |
10 mg | In stock | $ 278.00 | |
25 mg | In stock | $ 446.00 | |
50 mg | In stock | $ 657.00 |
Description | TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
Targets&IC50 | ErbB3:23 nM |
In vitro | TX1-85-1 has an anti-proliferation (EC50s: 9.9, 11.5, and 16.9 μM for Ovcar8, HCC827 GR6, and PC9 GR4 cells, respectively) [1]. |
Molecular Weight | 580.68 |
Formula | C32H36N8O3 |
CAS No. | 1603845-32-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.85 mg/mL (6.63 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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TX1-85-1 1603845-32-4 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR inhibit TX1851 ErbB-1 Epidermal growth factor receptor Inhibitor HER1 TX1 85 1 TX-1-85-1 inhibitor