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AZ-23

Catalog No. T14363   CAS 915720-21-7
Synonyms: AZ 23, AZ23

AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.

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AZ-23 Chemical Structure
AZ-23, CAS 915720-21-7
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25 mg 8-10 weeks $ 613.00
50 mg 8-10 weeks $ 797.00
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Purity: 99.4%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
Targets&IC50 TrkA:2 nM, TrkB:8 nM
In vitro AZ-23 potently and selectivity inhibits Trk phosphorylation in cells. AZ-23 potently inhibits Trk-mediated survival (EC50 of 2 nM) and it also Inhibits Trk-Dependent Survival in MCF10ATrkA-Δ and TF-1 Cell Lines[1].
In vivo Following oral administration in a TrkA-driven allograft model, AZ-23 demonstrates effective in vivo inhibition of TrkA kinase and efficacy in mice. It also significantly inhibits tumor growth in a Trk-expressing xenograft model of neuroblastoma[1].
Synonyms AZ 23, AZ23
Molecular Weight 391.83
Formula C17H19ClFN7O
CAS No. 915720-21-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (319.02 mM), sonification is recommended.

TargetMolReferences and Literature

1. Thress K, et al. Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway. Mol Cancer Ther. 2009 Jul; 8(7):1818-27.

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Keywords

AZ-23 915720-21-7 Tyrosine Kinase/Adaptors Trk receptor AZ 23 Tropomyosin related kinase receptor Inhibitor AZ23 inhibit Trk Receptor inhibitor

 

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