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AZ3451

Name: AZ3451
Brand: TargetMol
SKU: TQ0012
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0012Cas No. 2100284-59-9

AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).

AZ3451

🥰Excellent

Purity: 98.12%

Catalog No. TQ0012Cas No. 2100284-59-9

AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).

Pack Size	Price	Availability
2 mg	$38	In Stock
5 mg	$61	In Stock
10 mg	$98	In Stock
25 mg	$243	In Stock
50 mg	$428	In Stock
100 mg	$635	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Batch Information

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Purity:98.12%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	AZ3451 is an allosteric antagonist of protease-activated receptor-2 (PAR2, IC50: 23 nM).
Targets&IC50	PAR2:23 nM（kd）
In vitro	AZ3451 is selective for PAR2 over PAR4 and PAR1 (IC50s = <2.5, 380, and >50,000 nM, respectively, in a β-arrestin-2 recruitment assay). AZ3541 completely inhibits SLIGRL-induced phosphorylation of ERK in 1321N1 astrocytoma cells when used at a concentration of 10 μM.

Chemical Properties

Molecular Weight	571.46
Formula	C₃₀H₂₇BrN₄O₃
Cas No.	2100284-59-9
Smiles	C[C@@H](C1CCCCC1)n1c(nc2cc(ccc12)C(=O)Nc1ccc(cc1)C#N)-c1cc2OCOc2cc1Br
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 80 mg/mL (139.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7499 mL	8.7495 mL	17.4990 mL	87.4952 mL
5 mM	0.3500 mL	1.7499 mL	3.4998 mL	17.4990 mL
10 mM	0.1750 mL	0.8750 mL	1.7499 mL	8.7495 mL
20 mM	0.0875 mL	0.4375 mL	0.8750 mL	4.3748 mL
50 mM	0.0350 mL	0.1750 mL	0.3500 mL	1.7499 mL
100 mM	0.0175 mL	0.0875 mL	0.1750 mL	0.8750 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc