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Phe-Met-Arg-Phe, amide acetate

Catalog No. TP1858L CAS TP1858L

Synonyms: Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)

Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.

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Phe-Met-Arg-Phe, amide acetate Chemical Structure

Phe-Met-Arg-Phe, amide acetate, CAS TP1858L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 46.00
2 mg	In stock	$ 64.00
5 mg	In stock	$ 91.00
10 mg	In stock	$ 147.00
25 mg	In stock	$ 292.00
50 mg	In stock	$ 438.00
100 mg	In stock	$ 647.00

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Purity: 99.4%

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Description	Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.
Targets&IC50	K+ current (IKr):ED50: 23 nM
In vitro	In the molluscan central nervous system, Phe-Met-Arg-Phe, amide (FMRFa) acts on K+ channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe, amide activates a novel K+ current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels[1]. Phe-Met-Arg-Phe, amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe, amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM)[2].
In vivo	Phe-Met-Arg-Phe amide (FMRFamide) has been identified to stimulate growth hormone secretion in conscious ovariectomized (OVX) rats. Its immunoreactivity within hypothalamic neuronal elements hints at its involvement in regulating anterior pituitary functions. Administration of 200 ng (313.8 picomoles) of FMRFamide in a 2 uL volume significantly elevates plasma growth hormone (GH) levels within 15 minutes post-injection. Moreover, a dose range of 400-800 ng (627-1255 picomoles) of FMRFamide induces a rapid increase in GH levels, observable as early as 5 minutes and persisting for up to 30 minutes.

Synonyms	Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)
Molecular Weight	658.82
Formula	C31H46N8O6S
CAS No.	TP1858L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Kits KS, et al. Phe-Met-Arg-Phe-amide activates a novel voltage-dependent K+ current through a lipoxygenasepathway in molluscan neurones. J Gen Physiol. 1997 Nov;110(5):611-28.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Bioactive Compound Library Potassium Channel Blocker Library NO PAINS Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library

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Keywords

Phe-Met-Arg-Phe, amide acetate TP1858L Membrane transporter/Ion channel Potassium Channel 64190-70-1 freebase Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase) Phe Met Arg Phe, amide acetate PheMetArgPhe, amide acetate Phe-Met-Arg-Phe, amide Acetate inhibitor inhibit

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