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Amitifadine hydrochloride

Catalog No. T2092   CAS 410074-74-7
Synonyms: DOV-21947 hydrochloride, EB-1010 hydrochloride

Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

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Amitifadine hydrochloride Chemical Structure
Amitifadine hydrochloride, CAS 410074-74-7
Pack Size Availability Price/USD Quantity
25 mg In stock $ 839.00
50 mg 6-8 weeks $ 1,090.00
1 mL * 10 mM (in DMSO) In stock $ 318.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Targets&IC50 serotonin(in HEK 293 cells):12 nM, dopamine(in HEK 293 cells):96 nM, norepinephrine(in HEK 293 cells):23 nM
Synonyms DOV-21947 hydrochloride, EB-1010 hydrochloride
Molecular Weight 264.58
Formula C11H12Cl3N
CAS No. 410074-74-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.

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Tetrahydroberberine Zatebradine L-745870 trihydrochloride Zotepine ABT-724 D1R antagonist 1 Buspirone hydrochloride Fosopamine(HCl)

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Amitifadine hydrochloride 410074-74-7 GPCR/G Protein Neuroscience Norepinephrine Dopamine Receptor 5-HT Receptor Serotonin Transporter inhibit Inhibitor SERT Amitifadine EB1010 Hydrochloride Amitifadine Hydrochloride DOV-21947 hydrochloride EB 1010 DOV 21947 Hydrochloride EB-1010 Hydrochloride DOV21947 DOV 21947 DOV-21947 EB 1010 Hydrochloride SLC6A3 5-HTT EB-1010 hydrochloride EB-1010 DOV-21947 Hydrochloride EB1010 DAT SLC6A4 DOV21947 Hydrochloride Dopamine Transporter inhibitor

 

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