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Amitifadine hydrochloride
🥰Excellent
Catalog No. T2092Cas No. 410074-74-7
Alias EB-1010 hydrochloride, DOV-21947 hydrochloride
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Amitifadine hydrochloride
🥰Excellent
Catalog No. T2092Alias EB-1010 hydrochloride, DOV-21947 hydrochlorideCas No. 410074-74-7
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $239 | In Stock | |
| 10 mg | $396 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $263 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI). |
| Targets&IC50 | Norepinephrine (HEK293 cells):23 nM, 5-HT (HEK293 cells):12 nM, Dopamine (HEK293 cells):96 nM |
| Alias | EB-1010 hydrochloride, DOV-21947 hydrochloride |
| Molecular Weight | 264.58 |
| Formula | C11H12Cl3N |
| Cas No. | 410074-74-7 |
| Smiles | Cl.Clc1ccc(cc1Cl)[C@@]12C[C@@H]1CNC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mM, Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
SLC6A4SLC6A3SERTSerotoninTransporterSerotonin TransporterNorepinephrine (NE)InhibitorinhibitEB-1010 HydrochlorideEB1010 HydrochlorideEB-1010EB1010EB 1010 HydrochlorideEB 1010DOV-21947 HydrochlorideDOV21947 HydrochlorideDOV-21947DOV21947DOV 21947 HydrochlorideDOV 21947DopamineReceptorDopamine TransporterDopamine ReceptorDopamineDATAmitifadine hydrochlorideAmitifadine HydrochlorideAmitifadine5-HTT5HTReceptor5HT Receptor5-HT
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