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Amitifadine hydrochloride

Catalog No. T2092 CAS 410074-74-7

Synonyms: EB-1010 hydrochloride, DOV-21947 hydrochloride

Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).

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Amitifadine hydrochloride, CAS 410074-74-7

Pack Size	Availability	Price/USD
1 mg	Inquiry	79.00
2 mg	In stock	142.00
5 mg	In stock	321.00
10 mg	In stock	553.00
25 mg	In stock	780.00
50 mg	Inquiry	1455.00
1 mL * 10 mM (in DMSO)	Inquiry	354.00

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Purity 98.00%

HNMR COA

Purity 98.00%

COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Amitifadine hydrochloride is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI).
Targets&IC50	5-HT , Dopamine , Norepinephrine (NE)

Synonyms	EB-1010 hydrochloride , DOV-21947 hydrochloride
Purity	98.00%
Molecular Weight	264.58
Formula	C11H12Cl3N
CAS No.	410074-74-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Skolnick P, et al. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Clinical Compound Library Neuronal Signaling Compound Library Serotonin Receptor-Targeted Compound Library GPCR Compound Library Preclinical Compound Library Anti-Obesity Compound Library Neurotransmitter Receptor Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library

Related Products

Related compounds with same targets

Tandospirone GSK163090 Dexpramipexole Sumanirole maleate CP-809101 lumateperone Tosylate Nemifitide acetate(173240-15-8 free base) Neuromedin N acetate(92169-45-4 free base)

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.