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Search Result

Search Results for " β-catenin "

Targets

Wnt/beta-catenin

128

Compounds

31

Natural Products

14

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T9696 β-catenin-IN-2 Wnt/beta-catenin
β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.
T9988 Wnt/β-catenin agonist 3 Wnt/beta-catenin
Wnt/β-catenin agonist 3 is a Wnt/beta-catenin agonist.
T67884 β-catenin modulator IIa-661 Wnt/beta-catenin
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
TP1730L β-catenin peptide acetate(265669-37-2 free base) Others
β-catenin peptide(βCATp) acetate is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.
T41094 Wnt/β-catenin agonist 2 GSK-3 , Wnt/beta-catenin
Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist. Wnt/β-catenin agonist 2 can be used in the study of diseases related to signal transduction and is closely related to cancer inva...
T39200 β-catenin-IN-37
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of...
T60803 Wnt/β-catenin agonist 4 Wnt/beta-catenin
Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.
TP1730 β-catenin peptide
β-catenin peptide,(βCATp) is a naturally occurring self-peptide presented by Kb that very efficiently mediates positive selection of the OT-I thymocytes.
T6868 KYA1797K Wnt/beta-catenin
KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.
T12537 β-catenin/CBP-IN-1 Wnt/beta-catenin
β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-catenin
T8400 Pamidronic acid Wnt/beta-catenin
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
T8710 MSAB Wnt/beta-catenin
MSAB is a selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin, promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
T13344 Wnt/β-catenin agonist 1 Others
Wnt/β-catenin agonist 1 is an agonist of Wnt/β-catenin signalling pathway(EC50 of 0.27 μM).
T6989 SKL2001 Wnt/beta-catenin
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T15137 DK419 Wnt/beta-catenin , AMPK
DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM. DK419 decreases protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin.It also induces production of pAMPK.
T6113 ICG-001 Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.
T9182 NRX-252262 Others , Wnt/beta-catenin
NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50：3.8 nM)
T1971 WAY-262611 Wnt/beta-catenin
WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.
T15677 KY1220 Wnt/beta-catenin
KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.
T9151 Teplinovivint Wnt/beta-catenin
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
T7399 LF3 Wnt/beta-catenin
LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 (IC50 < 2 μM)
T7204 PNU-74654 Apoptosis , Wnt/beta-catenin
PNU 74654 binds to β-catenin (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway.
T21685 CCT 031374 hydrobromide Wnt/beta-catenin
CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.
T2413 FH535 Wnt/beta-catenin , PPAR
FH535, a Wnt/β-catenin signaling and PPAR inhibitor, exhibits anti-tumor activities.
T3635 IQ 1 IQ1,IQ-1 Wnt/beta-catenin
IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.
T5642 Tegatrabetan BC2059 Wnt/beta-catenin
Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.
T2161 Cardiogenol C Wnt/beta-catenin
Cardiogenol C is a cardiomyogenesis inducer in embryonic stem cells.
T10904 CWP232228 Wnt/beta-catenin
CWP232228, a potent and selective Wnt / β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting t...
T3062 WIKI4 PARP , Wnt/beta-catenin
WIKI4 is a potent inhibitor of Wnt/β-catenin signaling and tankyrase 2 (TNKS2).
T17142 Toxoflavin Xanthothricin,PKF-118-310,Toxoflavine Wnt/beta-catenin , Antibacterial , Antibiotic
Toxoflavin (Xanthothricin) is an antagonist of transcription factor 4 (TCF4)/β-catenin complex. Toxoflavin also acts as an inhibitor of KDM4A.
T0470 Nefopam hydrochloride Fenazoxine hydrochloride,Nefopam HCl Wnt/beta-catenin , Sodium Channel
Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.
T22884 JW 67 Wnt/beta-catenin
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
T72829 β-catenin-IN-4
β-Catenin-IN-4 is a β-catenin inhibitor characterized by a K_i value of 0.64 μM. This compound effectively lowers the protein expression levels of cyclin D1 and c-Myc.
T78919 β-catenin-IN-7
β-Catenin-IN-7 (Compound 9) is an inhibitor of β-catenin that disrupts its interaction with Tcf-4, consequently impeding Wnt-dependent gene expression, and exhibits anticancer activity [1].
T79102 β-Catenin modulator-3
β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-Catenin [1].
T1878 XAV-939 XAV939,NVP-XAV939 PARP , Wnt/beta-catenin
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11/4 nM). XAV-939 selectively inhibits Wnt/β-catenin-mediated transcription.
T79100 β-Catenin modulator-1
β-Catenin modulator-1 (IIa-650) is a useful agent in cancer research for modulating β-Catenin [1].
T79104 β-Catenin modulator-5
β-Catenin Modulator-5 (Compound IIa-84), an oxazole and thiazole-based compound, serves as a potent and selective modulator of β-Catenin [1].
T79101 β-Catenin modulator-2
β-Catenin Modulator-2 (Compound IIa-130), which is an oxazole-thiazole derivative, serves as a potent and selective modulator of β-Catenin [1].
T63212 β-catenin-IN-3
β-catenin-IN-3 is a selective and potent β-catenin inhibitor (KD: 54.96 nM) that targets a cryptic regulatory site of β-catenin and significantly reduces the viability of β-catenin-driven cancer cells.
T78120 β-catenin-IN-6
β-Catenin-IN-6 is an inhibitor of the canonical Wnt/β-catenin signaling pathway, effectively impeding the proliferation of human colorectal cancer cells and demonstrating efficacy in a β-catenin/RK3E mouse model [1] [2].
T79103 β-Catenin modulator-4
β-Catenin modulator-4 (compound IIa-92), encompassing oxazole and thiazole moieties, acts as a potent and selective modulator of β-Catenin [1].
T16079 Mirodenafil SK3530 PDE
Mirodenafil is a PDE-5 inhibitor developed for the treatment of erectile dysfunction.
T11284 FIDAS-3 Others , Wnt/beta-catenin , Methionine Adenosyltransferase (MAT)
FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for ...
T2310 CHIR-99021 Laduviglusib,CT99021,CHIR-99021 GSK-3 , Wnt/beta-catenin , Autophagy
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in...
T8005 Cardiogenol C hydrochloride Cardiogenol C HCl,Cardiogenol C Wnt/beta-catenin
Cardiogenol C hydrochloride (Cardiogenol C) can induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM).
T82235 HCA/Wnt/β-catenin-IN-1
hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-g...
T39341 FCPR03 PDE
FCPR03 is a selective inhibitor of phosphodiesterase 4 (PDE4) with IC50s of 31 nM, 47 nM, and 60 nM for PDE4B1, PDE4D7, and PDE4 catalytic domain, respectively. FCPR03 has neuroprotective, anti-inflammatory, and antidepr...
T10606 BRD0705 GSK-3
BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).
T11571 HLY78 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine Wnt/beta-catenin
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.

Compounds

β-catenin-IN-2
T9696
Synonym:
Target: Wnt/beta-catenin
Wnt/β-catenin agonist 3
T9988
Synonym:
Target: Wnt/beta-catenin
β-catenin modulator IIa-661
T67884
Synonym:
Target: Wnt/beta-catenin
β-catenin peptide acetate(265669-37-2 free base)
TP1730L
Synonym:
Target: Others
Wnt/β-catenin agonist 2
T41094
Synonym:
Target: GSK-3, Wnt/beta-catenin
β-catenin-IN-37
T39200
Synonym:
Target:
Wnt/β-catenin agonist 4
T60803
Synonym:
Target: Wnt/beta-catenin
β-catenin peptide
TP1730
Synonym:
Target:
KYA1797K
T6868
Synonym:
Target: Wnt/beta-catenin
β-catenin/CBP-IN-1
T12537
Synonym:
Target: Wnt/beta-catenin
Pamidronic acid
T8400
Synonym:
Target: Wnt/beta-catenin
MSAB
T8710
Synonym:
Target: Wnt/beta-catenin
Wnt/β-catenin agonist 1
T13344
Synonym:
Target: Others
SKL2001
T6989
Synonym:
Target: Wnt/beta-catenin
DK419
T15137
Synonym:
Target: Wnt/beta-catenin, AMPK
ICG-001
T6113
Synonym:
Target: Apoptosis, Epigenetic Reader Domain, Wnt/beta-catenin
NRX-252262
T9182
Synonym:
Target: Others, Wnt/beta-catenin
WAY-262611
T1971
Synonym:
Target: Wnt/beta-catenin
KY1220
T15677
Synonym:
Target: Wnt/beta-catenin
Teplinovivint
T9151
Synonym:
Target: Wnt/beta-catenin
LF3
T7399
Synonym:
Target: Wnt/beta-catenin
PNU-74654
T7204
Synonym:
Target: Apoptosis, Wnt/beta-catenin
CCT 031374 hydrobromide
T21685
Synonym:
Target: Wnt/beta-catenin
FH535
T2413
Synonym:
Target: Wnt/beta-catenin, PPAR
IQ 1
T3635
Synonym: IQ1,IQ-1
Target: Wnt/beta-catenin
Tegatrabetan
T5642
Synonym: BC2059
Target: Wnt/beta-catenin
Cardiogenol C
T2161
Synonym:
Target: Wnt/beta-catenin
CWP232228
T10904
Synonym:
Target: Wnt/beta-catenin
WIKI4
T3062
Synonym:
Target: PARP, Wnt/beta-catenin
Toxoflavin
T17142
Synonym: Xanthothricin,PKF-118-310,Toxoflavine
Target: Wnt/beta-catenin, Antibacterial, Antibiotic
Nefopam hydrochloride
T0470
Synonym: Fenazoxine hydrochloride,Nefopam HCl
Target: Wnt/beta-catenin, Sodium Channel
JW 67
T22884
Synonym:
Target: Wnt/beta-catenin
β-catenin-IN-4
T72829
Synonym:
Target:
β-catenin-IN-7
T78919
Synonym:
Target:
β-Catenin modulator-3
T79102
Synonym:
Target:
XAV-939
T1878
Synonym: XAV939,NVP-XAV939
Target: PARP, Wnt/beta-catenin
β-Catenin modulator-1
T79100
Synonym:
Target:
β-Catenin modulator-5
T79104
Synonym:
Target:
β-Catenin modulator-2
T79101
Synonym:
Target:
β-catenin-IN-3
T63212
Synonym:
Target:
β-catenin-IN-6
T78120
Synonym:
Target:
β-Catenin modulator-4
T79103
Synonym:
Target:
Mirodenafil
T16079
Synonym: SK3530
Target: PDE
FIDAS-3
T11284
Synonym:
Target: Others, Wnt/beta-catenin, Methionine Adenosyltransferase (MAT)
CHIR-99021
T2310
Synonym: Laduviglusib,CT99021,CHIR-99021
Target: GSK-3, Wnt/beta-catenin, Autophagy
Cardiogenol C hydrochloride
T8005
Synonym: Cardiogenol C HCl,Cardiogenol C
Target: Wnt/beta-catenin
hCA/Wnt/β-catenin-IN-1
T82235
Synonym:
Target:
FCPR03
T39341
Synonym:
Target: PDE
BRD0705
T10606
Synonym:
Target: GSK-3
HLY78
T11571
Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine
Target: Wnt/beta-catenin
1 2 3
Cat No. Product Name Synonyms Targets
T5729 L-quebrachitol Wnt/beta-catenin
L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
T3925 Astragaloside I Cyclosieversioside B,Astrasieversianin IV Wnt/beta-catenin
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen...
TN1079 Deoxyelephantopin NF-κB
Deoxyelephantopin has anti-inflammatory, hepatoprotective, and wound healing activities; it also has antitumor activity.Deoxyelephantopin inhibits NF-κB, MAPK, PI3K/Akt, and β-catenin signaling
T5679 (E)-Ferulic acid trans-Ferulic acid,(E)-Coniferic acid BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
TN1413 Atranorin Endogenous Metabolite , NO Synthase , Ras
Atranorin shows significant antinociceptive and antiinflammatory activities, it has a relevant redox-active action, acting as a pro-oxidant or antioxidant agent depending on the radical, also, it will exert cytoprotectiv...
T5S1058 Triptonide PG 492,NSC 165677 Apoptosis , Wnt/beta-catenin , Autophagy
1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, an...
TN7036 N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14 Wnt/beta-catenin
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...
TQ0215 Salinomycin sodium salt Sodium salinomycin,Salinomycin sodium Apoptosis , Wnt/beta-catenin , Antibacterial , Antibiotic , Autophagy
Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.
TN6508 Trachelogenin (-)-Trachelogenin Virus Protease , c-Myc , HCV Protease , Wnt/beta-catenin
Trachelogenin ((-)-Trachelogenin), isolated from Combretum fruticosum, is an HCV entry inhibitor with anti-proliferative effects. Its mechanism is related to affecting the phosphorylation of key proteins such as β-Cateni...
TL0008 Gigantol Wnt/beta-catenin , Glucosidase
Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...
T8229 5,7,3',4'-Tetramethoxyflavone Antibacterial , Parasite , Antifungal
5,7,3',4'-Tetramethoxyflavone (TMF), a prominent polymethoxyflavone (PMF) derived from M. exotica, displays a range of notable bioactivities. These include anti-malarial, anti-fungal, anti-mycobacterial, and anti-inflamm...
T3330 Trans-Trimethoxyresveratrol trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene Reactive Oxygen Species
trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy...
T0906 Salinomycin Procoxacin Wnt/beta-catenin , Antibacterial
Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria. It acts as a potent inhibitor of Wnt/β-catenin signaling, blocking Wnt-induced LRP6 phosph...
T4S1796 Heterophyllin B PI3K
Heterophyllin B effectively suppresses the adhesion and invasion of the human esophageal carcinoma cells by mediating the PI3K/AKT/β-catenin pathways and regulating the expression levels of adhesion- and invasion-associa...
TL0007 Bisdemethoxycurcumin Curcumin III,Didemethoxycurcumin Epigenetic Reader Domain , Wnt/beta-catenin
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by mac...
T2818 Methyl Vanillate Reactive Oxygen Species , Wnt/beta-catenin , Endogenous Metabolite
Methyl vanillate is Hovenia Dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. Methyl vanillate is considered to be a slightl...
T3391 Corosolic acid Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid FAK , Autophagy
Corosolic acid (Colosic acid) contains anti-angiogenic activity that can suppress FAK signaling induced by angiopoietin-1. Corosolic acid exerts anticancer activities against HCC, colon, and colorectal Y cells, by induci...
TN1103 Diphyllin ATPase , Proton pump , Influenza Virus , HIV Protease
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
T4S1943 Kirenol Kirel Wnt/beta-catenin
1. Kirenol (Kirel) has anti-oxidant, anti-inflammatory, anti-allergic, and anti-arthritic activities. 2. Kirenol is effective against gram-positive bacteria. 3. Kirenol possesses antitumor action on human chronic myeloid...
T2771 Orcinol glucoside Sakakin Antioxidant
Orcinol glucoside (Sakakin) (OG), an active constituent isolated from the rhizomes of Curculigo orchioides Gaertn, shows potent antioxidative and anxiolytic activities without sedative effects.
T3S0153 Xanthatin Apoptosis , VEGFR , Lipoxygenase , Wnt/beta-catenin , Antibacterial
1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell pr...
T3803 Specnuezhenide Nuzhenide,Nuezhenide Others , NF-κB , Wnt/beta-catenin
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t...
T1716 Echinacoside Reactive Oxygen Species , Wnt/beta-catenin
Echinacoside is a natural polyphenolic compound with various kinds of pharmacological activities, such as anti-inflammatory, antioxidative, hepatoprotective, neuroprotective, nitric oxide radical-scavenging and vasodilat...
T5S0754 Isoquercetin 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside NF-κB , Wnt/beta-catenin , NO Synthase
1. Isoquercetin (3-Glucosylquercetin) is a potential stimulator of bone mineralization used for prophylaxis of osteoporotic disorders. 2. Isoquercetin may be as a potential therapeutic agent against neurodegeneration in ...
T23645 Aeroplysinin 1 NSC170364,Aeroplysinin I,NSC 170364,NSC-170364
Aeroplysinin I is an antibacterial compound from the sponge. It has cytotoxic activity against colon cancer cells by promoting β-catenin degradation.
T1033L Monensin Elancoban,Rumensin
Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with d...
TN2371 Isoliquiritin Neoisoliquiritin Others
Neoisoliquiritigenin, isolated from Spatholobus suberectus, inhibits cell proliferation and induces cell apoptosis in breast cancer by directly binding to GRP78 to regulate the β-catenin pathway
T40643 Prodigiosin hydrochloride Prodigiosine hydrochloride
Prodigiosin hydrochloride, a red pigment, is a bioactive secondary metabolite produced by bacteria. It exhibits potent proapoptotic activity and functions as an inhibitor of the Wnt/β-catenin pathway. Additionally, this ...
TN3468 Atractylochromene Wnt/beta-catenin
Atractylochromene is an inhibitor of β-catenin dependent Wnt pathway, it may be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer.
T75621 Secalonic acid D
Secalonic acid D, a toxic compound effective against tumor cells, is derived from the metabolites of Aspergillus aculeatus. It operates by activating GSK3-β and degrading β-catenin, consequently down-regulating c-Myc exp...
TN2775 2-Methoxystypandrone MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...

Natural Products

L-quebrachitol
T5729
Synonym:
Target: Wnt/beta-catenin
Astragaloside I
T3925
Synonym: Cyclosieversioside B,Astrasieversianin IV
Target: Wnt/beta-catenin
Deoxyelephantopin
TN1079
Synonym:
Target: NF-κB
(E)-Ferulic acid
T5679
Synonym: trans-Ferulic acid,(E)-Coniferic acid
Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite
Atranorin
TN1413
Synonym:
Target: Endogenous Metabolite, NO Synthase, Ras
Triptonide
T5S1058
Synonym: PG 492,NSC 165677
Target: Apoptosis, Wnt/beta-catenin, Autophagy
N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide
TN7036
Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14
Target: Wnt/beta-catenin
Salinomycin sodium salt
TQ0215
Synonym: Sodium salinomycin,Salinomycin sodium
Target: Apoptosis, Wnt/beta-catenin, Antibacterial, Antibiotic, Autophagy
Trachelogenin
TN6508
Synonym: (-)-Trachelogenin
Target: Virus Protease, c-Myc, HCV Protease, Wnt/beta-catenin
Gigantol
TL0008
Synonym:
Target: Wnt/beta-catenin, Glucosidase
5,7,3',4'-Tetramethoxyflavone
T8229
Synonym:
Target: Antibacterial, Parasite, Antifungal
trans-Trimethoxyresveratrol
T3330
Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene
Target: Reactive Oxygen Species
Salinomycin
T0906
Synonym: Procoxacin
Target: Wnt/beta-catenin, Antibacterial
Heterophyllin B
T4S1796
Synonym:
Target: PI3K
Bisdemethoxycurcumin
TL0007
Synonym: Curcumin III,Didemethoxycurcumin
Target: Epigenetic Reader Domain, Wnt/beta-catenin
Methyl Vanillate
T2818
Synonym:
Target: Reactive Oxygen Species, Wnt/beta-catenin, Endogenous Metabolite
Corosolic acid
T3391
Synonym: Corsolic acid,2α-Hydroxyursolic acid,Glucosol,Colosolic acid,Colosic acid
Target: FAK, Autophagy
Diphyllin
TN1103
Synonym:
Target: ATPase, Proton pump, Influenza Virus, HIV Protease
Kirenol
T4S1943
Synonym: Kirel
Target: Wnt/beta-catenin
Orcinol glucoside
T2771
Synonym: Sakakin
Target: Antioxidant
Xanthatin
T3S0153
Synonym:
Target: Apoptosis, VEGFR, Lipoxygenase, Wnt/beta-catenin, Antibacterial
Specnuezhenide
T3803
Synonym: Nuzhenide,Nuezhenide
Target: Others, NF-κB, Wnt/beta-catenin
Echinacoside
T1716
Synonym:
Target: Reactive Oxygen Species, Wnt/beta-catenin
Isoquercetin
T5S0754
Synonym: 3-Glucosylquercetin,Hirsutrin,Isoquercitrin,Quercetin 3-o-glucopyranoside
Target: NF-κB, Wnt/beta-catenin, NO Synthase
Aeroplysinin 1
T23645
Synonym: NSC170364,Aeroplysinin I,NSC 170364,NSC-170364
Target:
Monensin
T1033L
Synonym: Elancoban,Rumensin
Target:
Isoliquiritin
TN2371
Synonym: Neoisoliquiritin
Target: Others
Prodigiosin hydrochloride
T40643
Synonym: Prodigiosine hydrochloride
Target:
Atractylochromene
TN3468
Synonym:
Target: Wnt/beta-catenin
Secalonic acid D
T75621
Synonym:
Target:
2-Methoxystypandrone
TN2775
Synonym:
Target: MMP, BCL, IκB/IKK, GSK-3, TNF, NOS, NF-κB, Wnt/beta-catenin, COX, JAK, STAT

Recombinant Proteins

Species：
Human (8)
Mouse (5)
Cynomolgus (1)
Expression System：
HEK293 (12)
Baculovirus-Insect Cells (2)
Tag：
C-hFc-Avi (4)
C-His (3)
C-hFc (2)
His,GST (2)
C-mFc (1)
N-His-Flag (1)
No Tag (1)
Cat No. Product Name Species Expression System
TMPY-02205 Beta-Catenin Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p...
TMPY-02985 Beta-Catenin Protein, Mouse, Recombinant (His & GST) Mouse Baculovirus-Insect Cells
beta-Catenin, also known as CTNNB1, is a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain, which is specialized for protein-protein binding. It is p...
TMPK-00744 LRP-6 Protein, Human, Recombinant (mFc) Human HEK293
Dickkopf-related protein 1 (DKK-1), a ligand for the WNT coreceptors low-density lipoprotein receptor-related proteins 5 and 6 (LRP-5 and LRP-6) and an inhibitor of WNT/β-catenin signaling, effectively inhibits pericyte ...
TMPK-00156 DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi) Human HEK293
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes.
TMPK-00158 DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes.
TMPK-01001 RNF43 Protein, Mouse, Recombinant (hFc) Mouse HEK293
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 i...
TMPK-00155 DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi) Human HEK293
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes.
TMPK-00157 DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated Human HEK293
Dickkopf-1 (Dkk1), the founding and best-studied member of the Dkk family, functions as an antagonist of canonical Wnt/β-catenin. Dkk1 is considered to play a broad role in a variety of biological processes.
TMPK-01106 Kremen-2 Protein, Human, Recombinant (His) Human HEK293
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi...
TMPK-01304 Kremen-2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi...
TMPK-01093 Kremen-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was signifi...
TMPK-00743 LGR-5 Protein, Human, Recombinant (hFc) Human HEK293
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker...
TMPK-00926 Noggin/NOG Protein, Mouse, Recombinant (His & Flag) Mouse HEK293
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G...
TMPK-00925 Noggin/NOG Protein, Mouse, Recombinant Mouse HEK293
Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer G...
Beta-Catenin Protein, Human, Recombinant (His & GST)
TMPY-02205
Species: Human
Expression System: Baculovirus-Insect Cells
Beta-Catenin Protein, Mouse, Recombinant (His & GST)
TMPY-02985
Species: Mouse
Expression System: Baculovirus-Insect Cells
LRP-6 Protein, Human, Recombinant (mFc)
TMPK-00744
Species: Human
Expression System: HEK293
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi)
TMPK-00156
Species: Human
Expression System: HEK293
DKK1 N terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPK-00158
Species: Human
Expression System: HEK293
RNF43 Protein, Mouse, Recombinant (hFc)
TMPK-01001
Species: Mouse
Expression System: HEK293
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi)
TMPK-00155
Species: Human
Expression System: HEK293
DKK1 C terminal Domain Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPK-00157
Species: Human
Expression System: HEK293
Kremen-2 Protein, Human, Recombinant (His)
TMPK-01106
Species: Human
Expression System: HEK293
Kremen-2 Protein, Cynomolgus, Recombinant (His)
TMPK-01304
Species: Cynomolgus
Expression System: HEK293
Kremen-2 Protein, Mouse, Recombinant (His)
TMPK-01093
Species: Mouse
Expression System: HEK293
LGR-5 Protein, Human, Recombinant (hFc)
TMPK-00743
Species: Human
Expression System: HEK293
Noggin/NOG Protein, Mouse, Recombinant (His & Flag)
TMPK-00926
Species: Mouse
Expression System: HEK293
Noggin/NOG Protein, Mouse, Recombinant
TMPK-00925
Species: Mouse
Expression System: HEK293
Cat No. Product Name
L2194 Anti-Colorectal Cancer Compound Library

1565 compounds
1565 compounds associated with colorectal cancer that can be used for high-throughput and high-content screening.
L7700 Neural Regeneration Compound Library

529 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L7900 Osteogenesis Compound Library

320 compounds
A unique collection of 320 osteogenesis related compounds for high throughput and high content screening;

Libraries

Anti-Colorectal Cancer Compound Library
L2194
Compounds: 1565
Neural Regeneration Compound Library
L7700
Compounds: 529
Osteogenesis Compound Library
L7900
Compounds: 320
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