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Specnuezhenide
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Catalog No. T3803Cas No. 39011-92-2
Alias Nuzhenide, Nuezhenide
Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling, thereby suppressing IL-1β-induced chondrocyte inflammation. It exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).
Specnuezhenide
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Purity: 99.93%
Catalog No. T3803Alias Nuzhenide, NuezhenideCas No. 39011-92-2
Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling, thereby suppressing IL-1β-induced chondrocyte inflammation. It exerts anti-inflammatory effects in a rat model of osteoarthritis (OA).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $31 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $77 | In Stock | In Stock | |
| 25 mg | $163 | In Stock | In Stock | |
| 50 mg | $243 | In Stock | In Stock | |
| 100 mg | $355 | In Stock | In Stock | |
| 200 mg | $526 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $74 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.93%
Color:White
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Product Introduction
Specnuezhenide AI Summary
Specnuezhenide inhibits adipocyte differentiation in mouse 3T3L1 cells by reducing 2 deoxy-D[3H]glucose uptake across various concentrations (0.2 mg/ml, 0.05 mg/ml, 0.5 mg/ml, and 1 mg/ml), with the inhibitory effect ranging from -15.2% to -38.2%. Additionally, this compound exhibits a PPARalpha activation activity of 12.2% when transfected into HEK cells, as measured by luciferase assay..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Specnuezhenide (Nuezhenide) is isolated from the fruit of Ligustrum lucidum. It inhibits NF-κB and wnt/β-catenin signaling, thereby suppressing IL-1β-induced chondrocyte inflammation. It exerts anti-inflammatory effects in a rat model of osteoarthritis (OA). |
| In vitro | METHODS: Chondrocytes were pretreated with Specnuezhenide (Nuezhenide) (0, 10, 50, 100, 200 μM) for 1 hour and then incubated with IL-1β (5 ng / ml) for 24 hours. Real-time fluorescence quantitative PCR was used to detect the mRNA expression of MMP3, MMP9, IL-6, iNOS, COX2, type II collagen and sox9; Chondrocytes were pretreated with SPN of Specnuezhenide (Nuezhenide) (0, 50, 100, 200 μM) for 1 hour and then incubated with IL-1β (5 ng / ml) for 48 hours. After harvesting the cells for protein blotting. The protein levels of MMP3, MMP9, IL-6, iNOS, COX2, type II collagen and sox9 were detected by Western blot. RESULTS Specnuezhenide (Nuezhenide) treatment downregulated the expression of MMP3, MMP9, IL-6, iNOS and COX2; Specnuezhenide (Nuezhenide) treatment downregulated the expression of COX2. A significant decrease in the protein levels of MMP3, MMP9, IL-6 and iNOS was observed in the high concentration group (200 μM). A significant increase in the protein levels of collagen II and sox9 was observed only in the 200 μM Specnuezhenide (Nuezhenide) treatment group. [1] |
| In vivo | METHODS: An OA model was established in SD rats by surgical transaction of ACL and MM. Rats in the Specnuezhenide (Nuezhenide) group were intra-articularly injected with 200μl Specnuezhenide (Nuezhenide) solution (200μM, 0.14mg/kg) every 7 days. Histological evaluation based on OASRI was used to evaluate the OA grade and observe the effect of Specnuezhenide (Nuezhenide) treatment on cartilage degeneration in OA rats. RESULTS The average OARSI grade of the SPN group was 2.95, and the level of inflammatory factors in the Specnuezhenide (Nuezhenide) group was reduced. Specnuezhenide (Nuezhenide) treatment played a chondroprotective role in the OA rat model. [1] |
| Synonyms | Nuzhenide, Nuezhenide |
| Molecular Weight | 686.66 |
| Formula | C31H42O17 |
| Cas No. | 39011-92-2 |
| Smiles | COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)\C(=C\C)[C@@H]1CC(=O)OC[C@H]1O[C@@H](OCCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |
| Relative Density. | 1.53 g/cm3 |
| Storage | keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 137.5 mg/mL (200.24 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (7.28 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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