keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 335.00 | |
10 mg | In stock | $ 537.00 | |
25 mg | In stock | $ 787.00 | |
50 mg | In stock | $ 1,070.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 345.00 |
Description | Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling. |
Targets&IC50 | HIV-1:0.38 μM (IC50), H+-ATPase (vacuolar type):17 nM (IC50) |
In vitro | The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively. |
Source |
Molecular Weight | 380.35 |
Formula | C21H16O7 |
CAS No. | 22055-22-7 |
keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.8 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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Diphyllin 22055-22-7 Membrane transporter/Ion channel Microbiology/Virology Proteases/Proteasome ATPase Proton pump Influenza Virus HIV Protease HIV-1 lignan Proton Pump HIV Human immunodeficiency virus Inhibitor cytotoxicity influenza arylnaphthalene VSV antiviral virus inhibit inhibitor