Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 41.00 | |
50 mg | In stock | $ 135.00 | |
100 mg | In stock | $ 203.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3]. |
Source |
Synonyms | Curcumin III, Didemethoxycurcumin |
Molecular Weight | 308.33 |
Formula | C19H16O4 |
CAS No. | 24939-16-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL
Ethanol: 5 mg/mL
You can also refer to dose conversion for different animals. More
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Bisdemethoxycurcumin 24939-16-0 Chromatin/Epigenetic Cytoskeletal Signaling Stem Cells Wnt/beta-catenin Epigenetic Reader Domain inhibit Inhibitor antiinflammatory curcuminoid antioxidant Curcumin III Bisdemethoxycucurmin Didemethoxycurcumin inhibitor