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Monensin

Catalog No. T1033L CAS 17090-79-8

Synonyms: Elancoban, Rumensin

Monensin is an antiprotozoal agent produced by Streptomyces cinnamonensis. It has an inhibitory effect on the Wnt/β-catenin signaling cascade. Monensin is a prospective anticancer drug for the therapy of neoplasia with deregulated Wnt signaling.

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Monensin, CAS 17090-79-8

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50 mg	Inquiry	$ 1,023.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	Elancoban, Rumensin
Molecular Weight	670.87
Formula	C36H62O11
CAS No.	17090-79-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. Abrar A, Tsukahara T, Kondo M, Ban-Tokuda T, Chao W, Matsui H. Effect of monensin withdrawal on rumen fermentation, methanogenesis and microbial populations in cattle. Anim Sci J. 2015 Sep;86(9):849-54. doi: 10.1111/asj.12368. Epub 2015 Mar 17. PubMed PMID: 25782058. 2. Linneen SK, McGee AL, Cole JR, Jennings JS, Stein DR, Horn GW, Lalman DL. Supplementation of monensin and Optimase to beef cows consuming low-quality forage during late gestation and early lactation. J Anim Sci. 2015 Jun;93(6):3076-83. doi: 10.2527/jas.2014-8406. PubMed PMID: 26115293. 3. Antonenko YN, Rokitskaya TI, Huczyński A. Electrogenic and nonelectrogenic ion fluxes across lipid and mitochondrial membranes mediated by monensin and monensin ethyl ester. Biochim Biophys Acta. 2015 Apr;1848(4):995-1004. doi: 10.1016/j.bbamem.2015.01.005. Epub 2015 Jan 17. PubMed PMID: 25600660. 4. Rocha BA, de Oliveira AR, Pazin M, Dorta DJ, Rodrigues AP, Berretta AA, Peti AP, de Moraes LA, Lopes NP, Pospíšil S, Gates PJ, Assis Md. Jacobsen catalyst as a cytochrome P450 biomimetic model for the metabolism of monensin A. Biomed Res Int. 2014;2014:152102. doi: 10.1155/2014/152102. Epub 2014 May 28. PubMed PMID: 24987668; PubMed Central PMCID: PMC4058456.

Citations

1. Luo Q, Liu Q, Cheng H, et al. Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses. Cell reports. 2022, 40(7): 111195. 2. Ma X, Liang X, Li Y, et al.Modular-designed engineered bacteria for precision tumor immunotherapy via spatiotemporal manipulation by magnetic field.Nature Communications.2023, 14(1): 1606.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Monensin 17090-79-8 Elancoban Rumensin inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.