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L-quebrachitol

Catalog No. T5729 CAS 642-38-6

L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.

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L-quebrachitol, CAS 642-38-6

Pack Size	Availability	Price/USD	Quantity
10 mg	In stock	$ 66.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.65%

Purity: 98%

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Storage & Solubility Information

Description	L-quebrachitol is a natural product.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
In vitro	L-quebrachitol significantly promotes proliferation and cell DNA synthesis. It also enhances mineralization accompanied by increases in mRNA expression of bone matrix proteins including alkaline phosphatase (ALP), collagen type I (ColI), osteocalcin (OCN), and osteopontin (OPN). In addition, l-quebrachitol upregulates the mRNA and protein expression of bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2), while down-regulating the receptor activator of the nuclear factor-κB ligand (RANKL) mRNA level. Moreover, the expression of regulatory genes associated with the mitogen-activated protein kinase (MAPK) and wingless-type MMTV integration site (Wnt)/β-catenin signaling pathways are also upregulated.L-quebrachitol may promote osteoblastogenesis by triggering the BMP-2-response as well as the Runx2, MAPK, and Wnt/β-catenin signaling pathway.
Cell Research	The total RNA from cells treated with l-quebrachitol was extracted using the TriPure Isolation Reagent .RNA (1 μg) was reverse transcribed using the Transcriptor First Strand cDNA Synthesis Kit to cDNA.The qRT-PCR analysis was performed using the EvaGreen HRM Mix .GAPDH was used as an internal control.The relative expression ratio was calculated using the 2^?△△Ct method.
Source	Natural Products > Apocynaceae > Aspidosperma

Molecular Weight	194.18
Formula	C7H14O6
CAS No.	642-38-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (115.87 mM)

References and Literature

1. Yodthong T, Kedjarune-Leggat U, Smythe C,et al.l-Quebrachitol Promotes the Proliferation, Differentiation, and Mineralization of MC3T3-E1 Cells: Involvement of the BMP-2/Runx2/MAPK/Wnt/β-Catenin Signaling Pathway[J].Molecules. 2018 Nov 26;23(12). pii: E3086.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Natural Product Library Anti-Inflammatory Traditional Chinese Medicine Compound Library Anti-Fibrosis Compound Library NO PAINS Compound Library Anti-Aging Compound Library Anti-Tumor Natural Product Library Neuronal Differentiation Compound Library Anti-Lung Cancer Compound Library Reprogramming Compound Library

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Related compounds with same targets

NRX-103094 ETC-159 CWP232228 PRI-724 Wnt/β-catenin agonist 3 iCRT 14 SKI II IQ 1

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Keywords

L-quebrachitol 642-38-6 Cytoskeletal Signaling Stem Cells Wnt/beta-catenin Beta catenin Wnt L quebrachitol Inhibitor Lquebrachitol L-Quebrachitol inhibit β-catenin inhibitor

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