Powder: -20°C for 3 years | In solvent: -80°C for 1 year
β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 970.00 |
Description | β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively. |
In vitro | 'β-catenin-IN-37 exhibits affinity for the β-catenin/Tcf protein-protein interaction (PPI), demonstrating dissociation constants (K_i values) of 17 μM and 18 μM in fluorescence polarization (FP) assay and AlphaScreen assay, respectively[1].' |
Molecular Weight | 307.277 |
Formula | C13H9N9O |
CAS No. | 1783856-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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β-catenin-IN-37 1783856-40-5 βcateninIN37 b-catenin-IN-37 beta-catenin-IN-37 β catenin IN 37 inhibitor inhibit